MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Gene	Rank	Value Type	Network Comparison Type	description	Interaction Map	Filtered	network_comparison	red	green

Results: HTML CSV LaTeX

Showing element 12864 to 12913 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	Value Type	Network Comparison Type	description	network_comparison	red	green
1608	Rooted	Subtracted	atrophin-1 (dentatorubral-pallidoluysian atrophy protein). [swissprot;acc:p54259]	2.2234	61.9701	64.1935
1609	Measured	Divided	26s proteasome non-atpase regulatory subunit 10 (26s proteasome regulatory subunit p28) (gankyrin). [swissprot;acc:o75832]	1.07134	5826.74	6242.44
		Subtracted	serine/threonine-protein kinase dcamkl1 (ec 2.7.1.-) (doublecortin- like and cam kinase-like 1). [swissprot;acc:o15075]	424.03	6297.05	6721.08
	Ranked	Divided	utp--glucose-1-phosphate uridylyltransferase 2 (ec 2.7.7.9) (udp- glucose pyrophosphorylase 2) (udpgp 2) (ugpase 2). [swissprot;acc:q16851]	1.0158	208.113	204.876
		Subtracted	apolipoprotein a-i binding protein; apoa-i binding protein. [refseq;acc:nm_144772]	3.254	207.916	204.662
	Squared	Divided	wilms' tumor 1-associating protein (wt1-associated protein). [swissprot;acc:q15007]	1.10876	28992.5	32145.6
		Subtracted	eukaryotic translation initiation factor 2 subunit 3 (eukaryotic translation initiation factor 2 gamma subunit) (eif-2-gamma). [swissprot;acc:p41091]	2510.8	24291.6	26802.4
	Rooted	Divided	proteasome subunit beta type 5 precursor (ec 3.4.25.1) (proteasome epsilon chain) (macropain epsilon chain) (multicatalytic endopeptidase complex epsilon chain) (proteasome subunit x) (proteasome chain 6) (proteasome subunit mb1). [swissprot;acc:p28074]	1.03494	65.5919	67.884
		Subtracted	sal-like protein 4 (zinc finger protein sall4). [swissprot;acc:q9ujq4]	2.2234	61.9701	64.1935
1610	Measured	Divided	eif-5a2 protein. [refseq;acc:nm_020390]	1.07126	6222.4	6665.83
		Subtracted	proto-oncogene tyrosine-protein kinase fes/fps (ec 2.7.1.112) (c-fes). [swissprot;acc:p07332]	423.93	6079.19	6503.12
	Ranked	Divided	ubiquitin-conjugating enzyme e2 variant 2; 1 alpha,25-dihydroxyvitamin d3-inducible; enterocyte differentiation promoting factor; methyl methanesulfonate sensitive 2, s. cerevisiae, homolog of. [refseq;acc:nm_003350]	1.01579	208.122	204.886
		Subtracted	c18b11 homolog (44.9kd). [refseq;acc:nm_152260]	3.246	217.446	214.2
	Squared	Divided	hiv-1 rev binding protein 2; rev interacting protein. [refseq;acc:nm_007043]	1.10866	15639.2	17338.5
		Subtracted	tata element modulatory factor (tmf). [swissprot;acc:p82094]	2510.1	23713.7	26223.8
	Rooted	Divided	sodium/iodide cotransporter (na(+)/i(-) cotransporter) (sodium-iodide symporter) (na+/i-symporter). [swissprot;acc:q92911]	1.03489	67.4766	69.831
		Subtracted	clathrin coat assembly protein ap180 (clathrin coat associated protein ap180) (91 kda synaptosomal-associated protein). [swissprot;acc:o60641]	2.2234	61.9701	64.1935
1611	Measured	Divided	cdc42-interacting protein 4 (thyroid receptor interacting protein 10) (trip-10). [swissprot;acc:q15642]	1.07119	5497.73	5132.35
		Subtracted	molybdenum cofactor synthesis protein 2 large subunit (molybdopterin synthase large subunit) (mpt synthase large subunit) (mocs2b) (moco1- b). [swissprot;acc:o96007]	423.93	6079.19	6503.12
	Ranked	Divided	p10-binding protein. [refseq;acc:nm_024491]	1.01577	221.313	217.877
		Subtracted	z-protein (protein cgi-119) (s1r protein). [swissprot;acc:q9hc24]	3.246	217.446	214.2
	Squared	Divided	heat shock factor binding protein 1. [swissprot;acc:o75506]	1.10865	27263.5	30225.7
		Subtracted	scy1-like 1; telomerase regulation-associated protein; ht019 protein; telomerase regulation-associated protein; n-terminal kinase-like protein; teratoma-associated tyrosine kinase; n-terminal kinase-like. [refseq;acc:nm_020680]	2510.1	23713.7	26223.8
	Rooted	Divided	kidney and liver proline oxidase 1. [refseq;acc:nm_021232]	1.03486	67.4958	69.8487
		Subtracted	arginine-glutamic acid dipeptide (re) repeats; atrophin 1-like; arginine glutamic acid dipeptide re repeats. [refseq;acc:nm_012102]	2.2233	61.9705	64.1938
1612	Measured	Divided	eukaryotic translation initiation factor 5a (eif-5a) (eif-4d) (rev- binding factor). [swissprot;acc:p10159]	1.07116	6212.98	6655.12
		Subtracted	anaphase-promoting complex subunit 10; anaphase-promoting complex 10. [refseq;acc:nm_014885]	423.93	6079.19	6503.12
	Ranked	Divided	enthoprotin; epsin 4; clathrin interacting protein localized in the trans-golgi region. [refseq;acc:nm_014666]	1.0157	221.426	224.902
		Subtracted	pp1201 protein. [refseq;acc:nm_022152]	3.246	217.446	214.2
	Squared	Divided	brain protein 16. [refseq;acc:nm_016458]	1.10845	26202.2	29043.8
		Subtracted	nuclear pore complex protein nup98 (nucleoporin nup98) (98 kda nucleoporin). [swissprot;acc:p52948]	2510.1	23713.7	26223.8
	Rooted	Divided	solute carrier family 5 (iodide transporter), member 8; apical iodide transporter. [refseq;acc:nm_145913]	1.03485	67.5045	69.8568
		Subtracted	ubiquitin carboxyl-terminal hydrolase 8 (ec 3.1.2.15) (ubiquitin thiolesterase 8) (ubiquitin-specific processing protease 8) (deubiquitinating enzyme 8). [swissprot;acc:p40818]	2.2233	61.9703	64.1936
1613	Measured	Divided	mitochondrial 28s ribosomal protein s22 (s22mt) (mrp-s22) (gk002). [swissprot;acc:p82650]	1.07106	6035.6	6464.5
		Subtracted	60s ribosomal protein l29 (cell surface heparin binding protein hip). [swissprot;acc:p47914]	423.93	6079.19	6503.12
	Ranked	Divided	hiv-1 tat interactive protein 2, 30kda; tat-interacting protein (30kd); hiv-1 tat interactive protein 2, 30 kda; hiv-1 tat interactive protein 2, 30 kd. [refseq;acc:nm_006410]	1.0157	182.378	185.241
		Subtracted	lifeguard; kiaa0950 protein. [refseq;acc:nm_012306]	3.246	217.446	214.2
	Squared	Divided	neuropilin- and tolloid-like protein 2 precursor. [refseq;acc:nm_018092]	1.10834	15399.5	17067.9
		Subtracted	ammecr1 protein. [refseq;acc:nm_015365]	2510.1	23713.7	26223.8
	Rooted	Divided	sodium-dependent multivitamin transporter (na(+)-dependent multivitamin transporter). [swissprot;acc:q9y289]	1.03484	67.511	69.8628
		Subtracted	rod1 regulator of differentiation 1; fission yeast differentiation regulator; regulator of differentiation (in s. pombi) 1; regulator of differentiation (in s. pombe) 1. [refseq;acc:nm_005156]	2.2233	61.9703	64.1936
1614	Measured	Divided	nefa-interacting nuclear protein nip30. [refseq;acc:nm_024946]	1.07106	6035.6	6464.5
		Subtracted	proto-oncogene tyrosine-protein kinase fer (ec 2.7.1.112) (p94-fer) (c-fer). [swissprot;acc:p16591]	423.93	6079.19	6503.12
	Ranked	Divided	hepatocyte nuclear factor 3-beta (hnf-3b) (forkhead box protein a2). [swissprot;acc:q9y261]	1.0156	217.233	213.897
		Subtracted	sterol regulatory element binding protein-2 (srebp-2) (sterol regulatory element-binding transcription factor 2). [swissprot;acc:q12772]	3.246	217.446	214.2
	Squared	Divided	neuropilin- and tolloid-like protein 1 isoform 3 precursor. [refseq;acc:nm_138966]	1.10834	15399.5	17067.9
		Subtracted	mrna-associated protein mrnp 41 (rae1 protein homolog). [swissprot;acc:p78406]	2510.1	23713.7	26223.8
	Rooted	Divided	trans-prenyltransferase; polyprenyl pyrophosphate synthetase. [refseq;acc:nm_014317]	1.03482	54.1932	56.0802
		Subtracted	polypyrimidine tract binding protein 2; neural polypyrimidine tract binding protein; ptb-like protein. [refseq;acc:nm_021190]	2.2233	61.9703	64.1936
1615	Measured	Divided	lim homeobox transcription factor 1 alpha (lim/homeobox protein lmx1a) (lim-homeobox protein 1.1) (lmx-1.1). [swissprot;acc:q8te12]	1.07106	6035.6	6464.5

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.