MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Gene	Value Type	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1508 to 1557 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Value Type	description	red	green	network_comparison
377	Rooted	mitochondrial ribosomal protein l2. [refseq;acc:nm_015950]	50.2554	45.5687	1.10285
378	Measured	hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0]	12471.7	14561.7	1.16758
	Ranked	60s ribosomal protein l30. [swissprot;acc:p04645]	242.593	265.365	1.09387
	Squared	eukaryotic translation initiation factor 4 gamma, 3. [refseq;acc:nm_003760]	15034.5	18552.2	1.23398
	Rooted	mitochondrial ribosomal protein l4 isoform a. [refseq;acc:nm_015956]	50.5816	45.8738	1.10263
379	Measured	ribonucleoside-diphosphate reductase m2 chain (ec 1.17.4.1) (ribonucleotide reductase small chain). [swissprot;acc:p31350]	6704.44	7811.45	1.16512
	Ranked	adenylate kinase isoenzyme 2, mitochondrial (ec 2.7.4.3) (atp-amp transphosphorylase). [swissprot;acc:p54819]	241.509	264.163	1.0938
	Squared	aminoadipate-semialdehyde synthase; lysine-ketoglutarate reductase /saccharopine dehydrogenase; lysine-2-oxoglutarate reductase; aminoadipic semialdehyde synthase. [refseq;acc:nm_005763]	33010.8	40732.2	1.23391
	Rooted	ptb domain adaptor protein ced-6; engulfment adapter protein. [refseq;acc:nm_016315]	59.5128	65.604	1.10235
380	Measured	acyl-coa dehydrogenase, very-long-chain specific, mitochondrial precursor (ec 1.3.99.-) (vlcad). [swissprot;acc:p49748]	12998.5	15138.2	1.16461
	Ranked	suppressor of ty 5 homolog; suppressor of ty (s.cerevisiae) 5 homolog. [refseq;acc:nm_003169]	242.109	264.79	1.09368
	Squared	ornithine decarboxylase-like protein (ec 4.1.1.17) (odc-paralogue) (odc-p). [swissprot;acc:q96a70]	32991.5	40704.5	1.23379
	Rooted	calcyphosine. [swissprot;acc:q13938]	59.5128	65.604	1.10235
381	Measured	multisynthetase complex auxiliary component p43 [contains: endothelial-monocyte activating polypeptide ii (emap-ii) (small inducible cytokine subfamily e member 1)]. [swissprot;acc:q12904]	5246.01	6109.31	1.16456
	Ranked	transcription initiation factor tfiid 55 kda subunit (tafii-55) (tafii55). [swissprot;acc:q15545]	200.586	183.423	1.09357
	Squared	ornithine decarboxylase antizyme inhibitor. [swissprot;acc:o14977]	32987.4	40698.5	1.23376
	Rooted	crooked neck-like protein 1 (crooked neck homolog) (hcrn) (cgi-201) (mstp021). [swissprot;acc:q9bzj0]	59.5128	65.604	1.10235
382	Measured	parkinson disease (autosomal recessive, juvenile) 2, parkin isoform 1; parkin. [refseq;acc:nm_004562]	4533.74	5279.4	1.16447
	Ranked	tata box binding protein-associated factor, rna polymerase ii, q; taf7-like rna polymerase ii, tata box binding protein (tbp)-associated factor, 50 kd; tbp-associated factor, rna polymerase ii, q. [refseq;acc:nm_024885]	200.791	183.66	1.09328
	Squared	rna-binding protein. [refseq;acc:nm_019027]	15043.7	18560.1	1.23375
	Rooted	40s ribosomal protein s23. [swissprot;acc:p39028]	49.8325	45.2077	1.1023
383	Measured	hepatoma-derived growth factor-related protein 2. [refseq;acc:nm_032631]	4533.74	5279.4	1.16447
	Ranked	rna-binding region containing protein 2 (hepatocellular carcinoma protein 1) (splicing factor hcc1). [swissprot;acc:q14498]	237.862	217.739	1.09242
	Squared	apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]	15043.7	18560.1	1.23375
	Rooted	28s ribosomal protein s12, mitochondrial precursor (mpr-s12) (mt- rps12). [swissprot;acc:o15235]	49.8325	45.2077	1.1023
384	Measured	cgi-142; hepatoma-derived growth factor 2. [refseq;acc:nm_016073]	4533.74	5279.4	1.16447
	Ranked	transcription factor e2f1 (e2f-1) (retinoblastoma binding protein 3) (rbbp-3) (prb-binding protein e2f-1) (pbr3) (retinoblastoma-associated protein 1) (rbap-1). [swissprot;acc:q01094]	266.421	244.236	1.09083
	Squared	ns1-associated protein 1. [refseq;acc:nm_006372]	15043.7	18560.1	1.23375
	Rooted	60s ribosomal protein l23 (l17). [swissprot;acc:p23131]	50.7723	46.0607	1.10229
385	Measured	pc4 and sfrs1 interacting protein 2; pc4 and sfrs1 interacting protein 1; transcriptional coactivator p52/p75. [refseq;acc:nm_033222]	4533.74	5279.4	1.16447
	Ranked	transcription factor e2f2 (e2f-2). [swissprot;acc:q14209]	266.421	244.236	1.09083
	Squared	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]	15043.7	18560.1	1.23375
	Rooted	brca2 and cdkn1a-interacting protein isoform bccipalpha; brca2 and cdkn1a-interacting protein; cdk inhibitor p21 binding protein; bccipalpha; bccipbeta; tok-1alpha; tok-1beta. [refseq;acc:nm_016567]	50.7723	46.0607	1.10229
386	Measured	60s ribosomal protein l8. [swissprot;acc:p25120]	4533.74	5279.4	1.16447
	Ranked	40s ribosomal protein s14 (pro2640). [swissprot;acc:p06366]	242.238	264.11	1.09029
	Squared	scratch; scratch 1. [refseq;acc:nm_031309]	40388.9	49827.5	1.23369
	Rooted	protein translation factor sui1 homolog gc20. [swissprot;acc:o60739]	50.0513	45.4124	1.10215
387	Measured	hepatoma-derived growth factor (hdgf) (high-mobility group protein 1- like 2) (hmg-1l2). [swissprot;acc:p51858]	4533.74	5279.4	1.16447
	Ranked	40s ribosomal protein s18 (ke-3) (ke3). [swissprot;acc:p25232]	242.238	264.11	1.09029
	Squared	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]	15053	18568	1.23351
	Rooted	60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914]	50.3345	45.6718	1.10209
388	Measured	pwwp domain containing 1; hdgf (hepatoma-derived growth factor) like. [refseq;acc:nm_138574]	4533.74	5279.4	1.16447
	Ranked	small nuclear ribonucleoprotein e (snrnp-e) (sm protein e) (sm-e) (sme). [swissprot;acc:p08578]	227.575	208.756	1.09015
	Squared	dj850e9.1 (novel c2h2 type zinc finger protein similar to drosophila scratch (scrt), slug and xenopus snail) (fragment). [sptrembl;acc:q9nq03]	40315.7	49716.4	1.23318
	Rooted	serine racemase (ec 5.1.1.-). [swissprot;acc:q9gzt4]	50.3345	45.6718	1.10209
389	Measured	probable atp-dependent rna helicase p54 (oncogene rck) (dead-box protein 6). [swissprot;acc:p26196]	4533.74	5279.4	1.16447
	Ranked	small nuclear ribonucleoprotein f (snrnp-f) (sm protein f) (sm-f) (smf). [swissprot;acc:q15356]	227.575	208.756	1.09015
	Squared	arginyl-trna synthetase-like; arginine-trna ligase. [refseq;acc:nm_020320]	31819.7	39222.2	1.23264
	Rooted	60s ribosomal protein l34. [swissprot;acc:p49207]	50.3345	45.6718	1.10209
390	Measured	rw1 protein (fragment). [swissprot;acc:q92545]	4533.74	5279.4	1.16447

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.