Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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description Rank Gene Value Type Filtered green Network Comparison Type Interaction Map red network_comparison
Results: HTML CSV LaTeX Showing element 1051 to 1100 of 3730 in total
Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence
description
Rank
Filtered
green
red
network_comparison
e1a binding protein p400; p400 swi2/snf2-related protein; cagh32 protein; trinucleotide repeat containing 12. [refseq;acc:nm_015409] 1456 1 6104.01 5672.25 1.07612
e1b-55kda-associated protein 5 isoform a. [refseq;acc:nm_007040] 2693 4095.53 4113.79 1.00446
e2a-pbx1-associated protein; putative 47 kda protein. [refseq;acc:nm_020140] 494 6842.72 5979.93 1.14428
eap30 subunit of ell complex. [refseq;acc:nm_007241] 497 4093.05 4682.87 1.1441
early endosome antigen 1, 162kd; early endosome-associated protein. [refseq;acc:nm_003566] 2151 5129.63 4871.11 1.05307
ebp50-pdz interactor of 64 kda (epi64 protein). [swissprot;acc:q9bxi6] 651 4597.44 5168.43 1.1242
ecotropic viral integration site 5; neuroblastoma stage 4s gene. [refseq;acc:nm_005665] 1235 6300.47 5807.83 1.08482
ecotropic virus integration 1 site protein. [swissprot;acc:q03112] 3170 0.00001 0.00001 1
egf-like-domain, multiple 7; neu1 protein. [refseq;acc:nm_016215] 1481 3431.33 3688.8 1.07504
eh-domain containing protein 1 (testilin) (hpast1). [swissprot;acc:q9h4m9] 2514 6360.25 6203.92 1.0252
eh-domain containing protein 2. [swissprot;acc:q9nzn4] 2517 6360.24 6203.96 1.02519
eh-domain containing protein 3. [swissprot;acc:q9nzn3] 2515 6360.25 6203.94 1.0252
eh-domain containing protein 4 (eh domain-containing protein fksg7) (hepatocellular carcinoma-associated protein 10/11). [swissprot;acc:q9h223] 2516 6360.24 6203.95 1.02519
eif-5a2 protein. [refseq;acc:nm_020390] 1610 6665.83 6222.4 1.07126
elac homolog 2; putative prostate cancer susceptibility protein; elac (e. coli) homolog 2. [refseq;acc:nm_018127] 2206 5326.29 5076.73 1.04916
elav-like protein 1 (hu-antigen r) (hur). [swissprot;acc:q15717] 2178 6193.33 5893.23 1.05092
elav-like protein 2 (hu-antigen b) (hub) (elav-like neuronal protein 1) (nervous system-specific rna binding protein hel-n1). [swissprot;acc:q12926] 2180 6200.24 5900.25 1.05084
elav-like protein 3 (hu-antigen c) (huc) (paraneoplastic cerebellar degeneration-associated antigen) (paraneoplastic limbic encephalitis antigen 21). [swissprot;acc:q14576] 435 0 5737.71 5891.28 1.02677
2177 1 6187.82 5887.43 1.05102
elav-like protein 4 (paraneoplastic encephalomyelitis antigen hud) (hu-antigen d). [swissprot;acc:p26378] 2179 6196.59 5896.51 1.05089
electron transfer flavoprotein alpha-subunit, mitochondrial precursor (alpha-etf). [swissprot;acc:p13804] 1749 8452.01 7919.76 1.06721
electron transfer flavoprotein beta-subunit (beta-etf). [swissprot;acc:p38117] 1761 8316.04 7794.41 1.06692
electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor (ec 1.5.5.1) (etf-qo) (etf-ubiquinone oxidoreductase) (etf dehydrogenase) (electron-transferring- flavoprotein dehydrogenase). [swissprot;acc:q16134] 1301 7161.67 6618.74 1.08203
elks protein. [refseq;acc:nm_015064] 1163 6343.59 5832.13 1.0877
ell-associated factor 2; uncharacterized bone marrow protein bm040; testosterone regulated apoptosis inducer and tumor suppressor. [refseq;acc:nm_018456] 2921 0.00001 0.00001 1
elongation factor 1-alpha 1 (ef-1-alpha-1) (elongation factor 1 a-1) (eef1a-1) (elongation factor tu) (ef-tu). [swissprot;acc:p04720] 83 0 100.887 166.114 1.64654
1733 1 6272.26 5874.83 1.06765
elongation factor 1-alpha 2 (ef-1-alpha-2) (elongation factor 1 a-2) (eef1a-2) (statin s1). [swissprot;acc:q05639] 1735
elongation factor 2 (ef-2). [swissprot;acc:p13639] 1069 6001.08 5494.73 1.09215
elongation factor ts, mitochondrial precursor (ef-ts) (ef-tsmt). [swissprot;acc:p43897] 43 0 587.988 263.66 2.2301
3027 1 0.00001 0.00001 1
elongation of very long chain fatty acids protein 1 (cgi-88). [swissprot;acc:q9bw60] 458 5610.96 4890.55 1.14731
elongation protein 4 homolog; pax6 neighbor gene; chromosome 11 open reading frame 19. [refseq;acc:nm_019040] 1344 6354.5 5887.86 1.07925
endo-beta-n-acetylglucosaminidase. [refseq;acc:nm_022759] 520 10986.4 9642.22 1.13941
endonuclease g, mitochondrial precursor (ec 3.1.30.-) (endo g). [swissprot;acc:q14249] 2695 5154.43 5176.92 1.00436
endosome-associated fyve-domain protein. [refseq;acc:nm_014733] 3200 0.00001 0.00001 1
endothelial-derived gene 1. [refseq;acc:nm_025205] 1807 6818.17 6399.54 1.06542
enhancer of filamentation 1 (hef1) (crk-associated substrate-related protein) (cas-l) (casl) (pp105) (neural precursor cell expressed developmentally down-regulated 9). [swissprot;acc:q14511] 202 6076.09 4812.01 1.26269
enhancer of rudimentary homolog. [swissprot;acc:q14259] 2072 6797.24 6437.24 1.05592
enhancer of zeste homolog 1 (enx-2). [swissprot;acc:q92800] 3090 0.00001 0.00001 1
enhancer of zeste homolog 2 (enx-1). [swissprot;acc:q15910] 3098
enigma protein; lim domain protein. [refseq;acc:nm_005451] 181 0 153 187.25 1.22386
1596 1 6070.32 5665.34 1.07148
enoyl-coa hydratase, mitochondrial precursor (ec 4.2.1.17) (short chain enoyl-coa hydratase) (sceh) (enoyl-coa hydratase 1). [swissprot;acc:p30084] 504 11511 10067.9 1.14334
enteropeptidase precursor (ec 3.4.21.9) (enterokinase). [swissprot;acc:p98073] 347 5885.09 4991.02 1.17914
enthoprotin; epsin 4; clathrin interacting protein localized in the trans-golgi region. [refseq;acc:nm_014666] 2022 5841.16 5520.26 1.05813
epidermal growth factor receptor kinase substrate eps8. [swissprot;acc:q12929] 1261 6157.53 5685.34 1.08305
epidermal growth factor receptor pathway substrate 8-like protein 1 isoform c; epidermal growth factor receptor pathway substrate 8-related protein 1; eps8-related protein 1. [refseq;acc:nm_139204] 1259 6157.7 5685.38 1.08308
epidermal growth factor receptor pathway substrate 8-like protein 2; eps8-related protein 2; epidermal growth factor receptor pathway substrate 8-related protein 2. [refseq;acc:nm_022772] 1270 6156.48 5685.08 1.08292
epidermal growth factor receptor precursor (ec 2.7.1.112) (receptor protein-tyrosine kinase erbb-1). [swissprot;acc:p00533] 1391 6192.7 5743.36 1.07824

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/