MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1180 to 1229 of 6456 in total

Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
590	ubiquitin-conjugating enzyme e2 variant 2; 1 alpha,25-dihydroxyvitamin d3-inducible; enterocyte differentiation promoting factor; methyl methanesulfonate sensitive 2, s. cerevisiae, homolog of. [refseq;acc:nm_003350]	Subtracted	6690.44	7443.29	752.85
591	homeobox protein hox-d9 (hox-4c) (hox-5.2). [swissprot;acc:p28356]	Divided	6740.5	7644.76	1.13415
	u4/u6-associated rna splicing factor. [refseq;acc:nm_004698]	Subtracted	5390.78	6142.07	751.29
592	arginyl-trna synthetase-like; arginine-trna ligase. [refseq;acc:nm_020320]		7093.86	7842.67	748.81
	histone h2b.c (h2b/c). [swissprot;acc:q99880]	Divided	3946.32	4475.47	1.13409
593	histone h2b.q (h2b/q) (h2b-gl105). [swissprot;acc:q16778]
	nadh-ubiquinone oxidoreductase b22 subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b22) (ci-b22). [swissprot;acc:q9y6m9]	Subtracted	6770.78	7517.97	747.19
594	histone h3.1 (h3/a) (h3/c) (h3/d) (h3/f) (h3/h) (h3/i) (h3/j) (h3/k) (h3/l). [swissprot;acc:p16106]	Divided	3946.32	4475.47	1.13409
	shroom-related protein; f-actin-binding protein; likely ortholog of mouse shroom. [refseq;acc:nm_020859]	Subtracted	6089.21	6835.34	746.13
595	apical-like protein (apxl protein). [swissprot;acc:q13796]		6088.77	6834.87	746.1
	histone h2b. [refseq;acc:nm_175055]	Divided	3946.32	4475.47	1.13409
596	histone h2b.s (h2b/s). [swissprot;acc:p57053]
	parkinson disease (autosomal recessive, juvenile) 2, parkin isoform 1; parkin. [refseq;acc:nm_004562]	Subtracted	4533.74	5279.4	745.66
597	hepatoma-derived growth factor-related protein 2. [refseq;acc:nm_032631]
	histone h2b.d (h2b/d). [swissprot;acc:q99877]	Divided	3946.32	4475.47	1.13409
598	cgi-142; hepatoma-derived growth factor 2. [refseq;acc:nm_016073]	Subtracted	4533.74	5279.4	745.66
	histone h3.4 (h3t) (h3/t) (h3/g). [swissprot;acc:q16695]	Divided	3946.32	4475.47	1.13409
599	pc4 and sfrs1 interacting protein 2; pc4 and sfrs1 interacting protein 1; transcriptional coactivator p52/p75. [refseq;acc:nm_033222]	Subtracted	4533.74	5279.4	745.66
	testis-specific histone h2b; h2b histone family, member u, (testis-specific). [refseq;acc:nm_170610]	Divided	3946.32	4475.47	1.13409
600	60s ribosomal protein l8. [swissprot;acc:p25120]	Subtracted	4533.74	5279.4	745.66
	histone h2b.e (h2b/e). [swissprot;acc:q99879]	Divided	3946.32	4475.47	1.13409
601	hepatoma-derived growth factor (hdgf) (high-mobility group protein 1- like 2) (hmg-1l2). [swissprot;acc:p51858]	Subtracted	4533.74	5279.4	745.66
	symplekin. [swissprot;acc:q92797]	Divided	15213.4	13418.1	1.1338
602	ataxin 2 related protein isoform a; ataxin-2 domain protein. [refseq;acc:nm_007245]		4864.66	5514.87	1.13366
	pwwp domain containing 1; hdgf (hepatoma-derived growth factor) like. [refseq;acc:nm_138574]	Subtracted	4533.74	5279.4	745.66
603	ataxin 2; olivopontocerebellar ataxia 2, autosomal dominant. [refseq;acc:nm_002973]	Divided	4864.66	5514.87	1.13366
	probable atp-dependent rna helicase p54 (oncogene rck) (dead-box protein 6). [swissprot;acc:p26196]	Subtracted	4533.74	5279.4	745.66
604	rw1 protein (fragment). [swissprot;acc:q92545]
	vinculin (metavinculin). [swissprot;acc:p18206]	Divided	5958.23	6743.37	1.13177
605	probable calcium-transporting atpase kiaa0703 (ec 3.6.3.8). [swissprot;acc:o75185]		6143.52	6950.75	1.1314
	rgs19-interacting protein 1 (gaip c-terminus interacting protein gipc) (rgs-gaip interacting protein) (tax interaction protein 2) (tip-2). [swissprot;acc:o14908]	Subtracted	6079.26	6824.47	745.21
606	calcium-transporting atpase type 2c, member 1 (ec 3.6.3.8) (atpase 2c1) (atp-dependent ca(2+) pump pmr1) (hussy-28). [swissprot;acc:p98194]	Divided	6148.94	6955.76	1.13121
	t-complex associated-testis-expressed 1-like (protein 91/23). [swissprot;acc:p51808]	Subtracted	10231.8	9487.34	744.46
607	double-strand break repair protein mre11a (mre11 homolog 1). [swissprot;acc:p49959]
	likely ortholog of mouse variant polyadenylation protein cstf-64. [refseq;acc:nm_015235]	Divided	14976.4	13246.6	1.13058
608	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]	Subtracted	2234.68	2978.53	743.85
	nuclear transcription factor y subunit beta (nf-y protein chain b) (nf-yb) (ccaat-binding transcription factor subunit a) (cbf-a) (caat- box dna binding protein subunit b). [swissprot;acc:p25208]	Divided	4510.61	5098.74	1.13039
609	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]		3886.62	3438.82	1.13022
	forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	Subtracted	2234.73	2978.57	743.84
610	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]		2236.61	2980.35	743.74
	kynureninase (ec 3.7.1.3) (l-kynurenine hydrolase). [swissprot;acc:q16719]	Divided	8430.03	9518.11	1.12907
611	dynein intermediate chain 2, cytosolic (dh ic-2) (cytoplasmic dynein intermediate chain 2). [swissprot;acc:q13409]		5148.71	5811.74	1.12878
	fibulin-2 precursor. [swissprot;acc:p98095]	Subtracted	8670.59	9412.9	742.31
612	cystathionine beta-synthase (ec 4.2.1.22) (serine sulfhydrase) (beta-thionase). [swissprot;acc:p35520]		5480.24	6222.04	741.8
	eukaryotic translation initiation factor 3 subunit 2 (eif-3 beta) (eif3 p36) (eif3i) (tgf-beta receptor interacting protein 1) (trip-1). [swissprot;acc:q13347]	Divided	3975.77	4485.05	1.1281
613	transforming protein rhoc (h9). [swissprot;acc:p08134]	Subtracted	5480.24	6222.04	741.8
	trinucleotide repeat containing 15. [refseq;acc:nm_015575]	Divided	3975.77	4485.05	1.1281
614	solute carrier family 4 (anion exchanger), member 1, adaptor protein; kidney anion exchanger adaptor protein; kanadaptin; lung cancer oncogene 3. [refseq;acc:nm_018158]		11222.2	9948.93	1.12798
	thiosulfate sulfurtransferase (ec 2.8.1.1) (rhodanese). [swissprot;acc:q16762]	Subtracted	5480.24	6222.04	741.8
615	3-mercaptopyruvate sulfurtransferase (ec 2.8.1.2) (mst). [swissprot;acc:p25325]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.