Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 1180 to 1229 of 6456 in total 
Value Type	Measured
Interaction Map	High confidence
Filtered	1

Rank	description	Network Comparison Type	red	green	network_comparison	
590	ubiquitin-conjugating enzyme e2 variant 2; 1 alpha,25-dihydroxyvitamin d3-inducible; enterocyte differentiation promoting factor; methyl methanesulfonate sensitive 2, s. cerevisiae, homolog of. [source:refseq;acc:nm_003350]	Subtracted	6690.44	7443.29	752.85	
591	homeobox protein hox-d9 (hox-4c) (hox-5.2). [source:swissprot;acc:p28356]	Divided	6740.5	7644.76	1.13415	
591	u4/u6-associated rna splicing factor. [source:refseq;acc:nm_004698]	Subtracted	5390.78	6142.07	751.29	
592	arginyl-trna synthetase-like; arginine-trna ligase. [source:refseq;acc:nm_020320]	Subtracted	7093.86	7842.67	748.81	
592	histone h2b.c (h2b/c). [source:swissprot;acc:q99880]	Divided	3946.32	4475.47	1.13409	
593	histone h2b.q (h2b/q) (h2b-gl105). [source:swissprot;acc:q16778]	Divided	3946.32	4475.47	1.13409	
593	nadh-ubiquinone oxidoreductase b22 subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b22) (ci-b22). [source:swissprot;acc:q9y6m9]	Subtracted	6770.78	7517.97	747.19	
594	histone h3.1 (h3/a) (h3/c) (h3/d) (h3/f) (h3/h) (h3/i) (h3/j) (h3/k) (h3/l). [source:swissprot;acc:p16106]	Divided	3946.32	4475.47	1.13409	
594	shroom-related protein; f-actin-binding protein; likely ortholog of mouse shroom. [source:refseq;acc:nm_020859]	Subtracted	6089.21	6835.34	746.13	
595	apical-like protein (apxl protein). [source:swissprot;acc:q13796]	Subtracted	6088.77	6834.87	746.1	
595	histone h2b. [source:refseq;acc:nm_175055]	Divided	3946.32	4475.47	1.13409	
596	histone h2b.s (h2b/s). [source:swissprot;acc:p57053]	Divided	3946.32	4475.47	1.13409	
596	parkinson disease (autosomal recessive, juvenile) 2, parkin isoform 1; parkin. [source:refseq;acc:nm_004562]	Subtracted	4533.74	5279.4	745.66	
597	hepatoma-derived growth factor-related protein 2. [source:refseq;acc:nm_032631]	Subtracted	4533.74	5279.4	745.66	
597	histone h2b.d (h2b/d). [source:swissprot;acc:q99877]	Divided	3946.32	4475.47	1.13409	
598	cgi-142; hepatoma-derived growth factor 2. [source:refseq;acc:nm_016073]	Subtracted	4533.74	5279.4	745.66	
598	histone h3.4 (h3t) (h3/t) (h3/g). [source:swissprot;acc:q16695]	Divided	3946.32	4475.47	1.13409	
599	pc4 and sfrs1 interacting protein 2; pc4 and sfrs1 interacting protein 1; transcriptional coactivator p52/p75. [source:refseq;acc:nm_033222]	Subtracted	4533.74	5279.4	745.66	
599	testis-specific histone h2b; h2b histone family, member u, (testis-specific). [source:refseq;acc:nm_170610]	Divided	3946.32	4475.47	1.13409	
600	60s ribosomal protein l8. [source:swissprot;acc:p25120]	Subtracted	4533.74	5279.4	745.66	
600	histone h2b.e (h2b/e). [source:swissprot;acc:q99879]	Divided	3946.32	4475.47	1.13409	
601	hepatoma-derived growth factor (hdgf) (high-mobility group protein 1- like 2) (hmg-1l2). [source:swissprot;acc:p51858]	Subtracted	4533.74	5279.4	745.66	
601	symplekin. [source:swissprot;acc:q92797]	Divided	15213.4	13418.1	1.1338	
602	ataxin 2 related protein isoform a; ataxin-2 domain protein. [source:refseq;acc:nm_007245]	Divided	4864.66	5514.87	1.13366	
602	pwwp domain containing 1; hdgf (hepatoma-derived growth factor) like. [source:refseq;acc:nm_138574]	Subtracted	4533.74	5279.4	745.66	
603	ataxin 2; olivopontocerebellar ataxia 2, autosomal dominant. [source:refseq;acc:nm_002973]	Divided	4864.66	5514.87	1.13366	
603	probable atp-dependent rna helicase p54 (oncogene rck) (dead-box protein 6). [source:swissprot;acc:p26196]	Subtracted	4533.74	5279.4	745.66	
604	rw1 protein (fragment). [source:swissprot;acc:q92545]	Subtracted	4533.74	5279.4	745.66	
604	vinculin (metavinculin). [source:swissprot;acc:p18206]	Divided	5958.23	6743.37	1.13177	
605	probable calcium-transporting atpase kiaa0703 (ec 3.6.3.8). [source:swissprot;acc:o75185]	Divided	6143.52	6950.75	1.1314	
605	rgs19-interacting protein 1 (gaip c-terminus interacting protein gipc) (rgs-gaip interacting protein) (tax interaction protein 2) (tip-2). [source:swissprot;acc:o14908]	Subtracted	6079.26	6824.47	745.21	
606	calcium-transporting atpase type 2c, member 1 (ec 3.6.3.8) (atpase 2c1) (atp-dependent ca(2+) pump pmr1) (hussy-28). [source:swissprot;acc:p98194]	Divided	6148.94	6955.76	1.13121	
606	t-complex associated-testis-expressed 1-like (protein 91/23). [source:swissprot;acc:p51808]	Subtracted	10231.8	9487.34	744.46	
607	double-strand break repair protein mre11a (mre11 homolog 1). [source:swissprot;acc:p49959]	Subtracted	10231.8	9487.34	744.46	
607	likely ortholog of mouse variant polyadenylation protein cstf-64. [source:refseq;acc:nm_015235]	Divided	14976.4	13246.6	1.13058	
608	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [source:refseq;acc:nm_138457]	Subtracted	2234.68	2978.53	743.85	
608	nuclear transcription factor y subunit beta (nf-y protein chain b) (nf-yb) (ccaat-binding transcription factor subunit a) (cbf-a) (caat- box dna binding protein subunit b). [source:swissprot;acc:p25208]	Divided	4510.61	5098.74	1.13039	
609	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [source:refseq;acc:nm_015681]	Divided	3886.62	3438.82	1.13022	
609	forkhead box protein p1 (hspc215). [source:swissprot;acc:q9h334]	Subtracted	2234.73	2978.57	743.84	
610	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [source:swissprot;acc:q9bzs1]	Subtracted	2236.61	2980.35	743.74	
610	kynureninase (ec 3.7.1.3) (l-kynurenine hydrolase). [source:swissprot;acc:q16719]	Divided	8430.03	9518.11	1.12907	
611	dynein intermediate chain 2, cytosolic (dh ic-2) (cytoplasmic dynein intermediate chain 2). [source:swissprot;acc:q13409]	Divided	5148.71	5811.74	1.12878	
611	fibulin-2 precursor. [source:swissprot;acc:p98095]	Subtracted	8670.59	9412.9	742.31	
612	cystathionine beta-synthase (ec 4.2.1.22) (serine sulfhydrase) (beta-thionase). [source:swissprot;acc:p35520]	Subtracted	5480.24	6222.04	741.8	
612	eukaryotic translation initiation factor 3 subunit 2 (eif-3 beta) (eif3 p36) (eif3i) (tgf-beta receptor interacting protein 1) (trip-1). [source:swissprot;acc:q13347]	Divided	3975.77	4485.05	1.1281	
613	transforming protein rhoc (h9). [source:swissprot;acc:p08134]	Subtracted	5480.24	6222.04	741.8	
613	trinucleotide repeat containing 15. [source:refseq;acc:nm_015575]	Divided	3975.77	4485.05	1.1281	
614	solute carrier family 4 (anion exchanger), member 1, adaptor protein; kidney anion exchanger adaptor protein; kanadaptin; lung cancer oncogene 3. [source:refseq;acc:nm_018158]	Divided	11222.2	9948.93	1.12798	
614	thiosulfate sulfurtransferase (ec 2.8.1.1) (rhodanese). [source:swissprot;acc:q16762]	Subtracted	5480.24	6222.04	741.8	
615	3-mercaptopyruvate sulfurtransferase (ec 2.8.1.2) (mst). [source:swissprot;acc:p25325]	Subtracted	5480.24	6222.04	741.8	

Legend:
- Rank is the rank after comparing the two networks
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/