Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene Hugo Value Type description Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 1100 to 1149 of 12912 in total
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1
Rank
Hugo
Value Type
description
red
green
network_comparison
275 RGS19 Measured regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795] 3119.98 2579.49 1.20953
276 CUTL2 Rooted homeobox protein cux-2 (cut-like 2) (fragment). [swissprot;acc:o14529] 66.1046 74.0964 1.1209
PRMT8 Squared protein arginine n-methyltransferase 4 (ec 2.1.1.-). [swissprot;acc:q9nr22] 16120.1 20665.7 1.28198
RBM15 Measured putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37] 3119.98 2579.49 1.20953
SNORA7A Ranked 60s ribosomal protein l32. [swissprot;acc:p02433] 241.13 266.969 1.10716
277 no value 40s ribosomal protein s29. [swissprot;acc:p30054] 241.849 267.642 1.10665
RGS20 Measured regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081] 3119.98 2579.49 1.20953
RPS6KC1 Rooted ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424] 65.9938 73.9449 1.12048
SNRP70 Squared u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [swissprot;acc:p08621] 16120.1 20665.7 1.28198
278 no value filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]
Rooted ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464] 65.9938 73.9449 1.12048
LBX1 Measured transcription factor lbx1. [swissprot;acc:p52954] 3119.98 2579.49 1.20953
RPS11 Ranked 40s ribosomal protein s11. [swissprot;acc:p04643] 241.399 267.088 1.10642
279 GPSM2 Measured mosaic protein lgn. [swissprot;acc:p81274] 3119.98 2579.49 1.20953
MSI2 Squared musashi 2 isoform a. [refseq;acc:nm_138962] 15569.5 19953.6 1.28158
RBBP7 Ranked histone acetyltransferase type b subunit 2 (retinoblastoma binding protein p46) (retinoblastoma-binding protein 7) (rbbp-7). [swissprot;acc:q16576] 252.644 228.42 1.10605
WASL Rooted neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401] 66.0989 74.0609 1.12046
280 no value ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36] 57.9068 64.8562 1.12001
MSI1 Squared musashi 1. [refseq;acc:nm_002442] 15569.5 19953.6 1.28158
MTA1 Ranked metastasis-associated protein mta1. [swissprot;acc:q13330] 252.512 228.356 1.10578
RGS17 Measured regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6] 3119.98 2579.49 1.20953
281 no value Ranked 60s ribosomal protein l17 (l23). [swissprot;acc:p18621] 241.808 267.335 1.10557
GNAO1 Measured guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471] 3119.98 2579.49 1.20953
SNRPA1 Rooted u2 small nuclear ribonucleoprotein a' (u2 snrnp-a'). [swissprot;acc:p09661] 57.9068 64.8562 1.12001
ZC3H14 Squared nuclear protein ukp68. [refseq;acc:nm_024824] 15569.5 19953.6 1.28158
282 CLEC11A stem cell growth factor; lymphocyte secreted c-type lectin; lymphocyte secreted c-type lectin. [refseq;acc:nm_002975] 59704 76460.4 1.28066
RAP1GAP Measured rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736] 3119.98 2579.49 1.20953
RBBP4 Ranked chromatin assembly factor 1 subunit c (caf-1 subunit c) (chromatin assembly factor i p48 subunit) (caf-i 48 kda subunit) (caf-ip48) (retinoblastoma binding protein p48) (retinoblastoma-binding protein 4) (rbbp-4) (msi1 protein homolog). [swissprot;acc:q09028] 252.39 228.297 1.10553
SF3A2 Rooted splicing factor 3a subunit 2 (spliceosome associated protein 62) (sap 62) (sf3a66). [swissprot;acc:q15428] 57.9819 64.9302 1.11984
283 DTX2 Squared deltex 2. [refseq;acc:nm_020892] 6627.24 8484.19 1.2802
KLF5 Rooted krueppel-like factor 5 (intestinal-enriched krueppel-like factor) (colon krueppel-like factor) (transcription factor bteb2) (basic transcription element binding protein 2) (bte-binding protein 2) (gc box binding protein 2). [swissprot;acc:q13887] 57.9819 64.9302 1.11984
POLI Measured polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195] 5221.28 6314.35 1.20935
RPL11 Ranked 60s ribosomal protein l11. [swissprot;acc:p39026] 241.828 267.346 1.10552
284 BCAR1 crk-associated substrate (p130cas) (breast cancer anti-estrogen resistance 1 protein). [swissprot;acc:p56945] 224.657 203.235 1.10541
CLEC3A Squared c-type lectin superfamily member 1 precursor (cartilage-derived c-type lectin). [swissprot;acc:o75596] 59464 76120.8 1.28012
CSRP1 Rooted cysteine-rich protein 1 (crp1) (crp). [swissprot;acc:p21291] 51.8647 46.3161 1.1198
PXN Measured paxillin. [swissprot;acc:p49023] 5221.28 6314.35 1.20935
285 CCT4 Ranked t-complex protein 1, delta subunit (tcp-1-delta) (cct-delta) (stimulator of tar rna binding). [swissprot;acc:p50991] 224.647 203.242 1.10532
DDX54 Rooted atp-dependent rna helicase mgc2835; atp-dependent rna helicase; apoptosis related protein apr-5; dead box helicase 97 kda. [refseq;acc:nm_024072] 48.4278 54.2262 1.11973
DTX1 Squared deltex homolog 1; hdx-1. [refseq;acc:nm_004416] 6680.89 8549.44 1.27969
PAPOLA Measured poly(a) polymerase alpha (ec 2.7.7.19) (pap) (polynucleotide adenylyltransferase alpha) (fragment). [swissprot;acc:p51003] 23326.5 19296.4 1.20885
286 CSRP2 Rooted smooth muscle cell lim protein (cysteine-rich protein 2) (crp2) (lim-only protein 5). [swissprot;acc:q16527] 51.8717 46.3287 1.11965
EXOC2 Measured exocyst complex component sec5. [swissprot;acc:q96kp1] 23316 19288.8 1.20878
NEDD9 Ranked enhancer of filamentation 1 (hef1) (crk-associated substrate-related protein) (cas-l) (casl) (pp105) (neural precursor cell expressed developmentally down-regulated 9). [swissprot;acc:q14511] 224.633 203.251 1.1052
PBK Squared t-lak cell-originated protein kinase; spermatogenesis-related protein kinase; pdz-binding kinase; pbk; mapkk-like protein kinase; serine/threonine protein kinase. [refseq;acc:nm_018492] 6693.64 8564.94 1.27956
287 KHDRBS3 kh domain containing, rna binding, signal transduction associated 3; sam68-like phosphotyrosine protein, t-star. [refseq;acc:nm_006558]
PAPOLG Measured poly(a) polymerase gamma (ec 2.7.7.19) (pap gamma) (polynucleotide adenylyltransferase gamma) (srp rna 3' adenylating enzyme). [swissprot;acc:q9bwt3] 23303.1 19279.5 1.2087
RPS4Y2 Ranked 40s ribosomal protein s4, y isoform 2. [swissprot;acc:q8td47] 240.758 266.079 1.10517
SHCBP1 Rooted likely ortholog of mouse shc sh2-domain binding protein 1. [refseq;acc:nm_024745] 51.8714 46.3281 1.11965
288 no value Ranked 40s ribosomal protein s4, x isoform (single copy abundant mrna protein) (scr10). [swissprot;acc:p12750] 240.758 266.078 1.10517

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/