MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1051 to 1100 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	red	green	network_comparison
1051	17 beta-hydroxysteroid dehydrogenase. [sptrembl;acc:q13034]	211.449	217.998	1.03097
1052	retinol dehydrogenase 8 (all-trans); photoreceptor outer segment all-trans retinol dehydrogenase. [refseq;acc:nm_015725]
1053	proteasome subunit alpha type 5 (ec 3.4.25.1) (proteasome zeta chain) (macropain zeta chain) (multicatalytic endopeptidase complex zeta chain). [swissprot;acc:p28066]	207.04	200.84	1.03087
1054	60s ribosomal protein l21. [swissprot;acc:p46778]	223.958	217.263	1.03082
1055	hcv ns3-transactivated protein 1. [refseq;acc:nm_019048]	219.01	212.468	1.03079
1056	vacuolar atp synthase catalytic subunit a, ubiquitous isoform (ec 3.6.3.14) (v-atpase a subunit 1) (vacuolar proton pump alpha subunit 1) (v-atpase 69 kda subunit 1) (isoform va68). [swissprot;acc:p38606]
1057	asparagine synthetase [glutamine-hydrolyzing] (ec 6.3.5.4) (glutamine- dependent asparagine synthetase) (ts11 cell cycle control protein). [swissprot;acc:p08243]
1058	ataxin 2 related protein isoform a; ataxin-2 domain protein. [refseq;acc:nm_007245]	228.105	221.293	1.03078
1059	ataxin 2; olivopontocerebellar ataxia 2, autosomal dominant. [refseq;acc:nm_002973]
1060	nemo-like kinase; likely ortholog of mouse nemo like kinase. [refseq;acc:nm_016231]	218.162	211.648
1061	elks protein. [refseq;acc:nm_015064]
1062	zinc finger protein 174 (aw-1). [swissprot;acc:q15697]	269.963	278.239	1.03066
1063	zinc finger imprinted 2. [swissprot;acc:q9nzv7]	269.96	278.232	1.03064
1064	zinc finger protein 24 (zinc finger protein 191) (zinc finger protein kox17) (retinoic acid suppression protein a) (rsg-a). [swissprot;acc:p17028]	269.955	278.221	1.03062
1065	zinc finger protein 305. [swissprot;acc:o43309]	269.954	278.219
1066	zinc finger protein 18 (zinc finger protein kox11) (fragment). [swissprot;acc:p17022]	269.956	278.223
1067	zinc finger protein 215 (bwscr2 associated zinc-finger protein 2) (baz 2). [swissprot;acc:q9ul58]
1068	zinc finger protein 274 (zinc finger protein sp2114) (zinc finger protein hfb101) (zinc finger protein zfp2) (zf2). [swissprot;acc:q96gc6]	269.953	278.215	1.03061
1069	zinc finger protein 232. [swissprot;acc:q9uny5]	269.954	278.218
1070	zinc finger protein 99. [refseq;acc:nm_032164]
1071	dna-directed rna polymerase i 16 kda polypeptide (ec 2.7.7.6) (rpa16). [swissprot;acc:q9y2s0]	231.277	238.356
1072	zinc finger protein 213 (putative transcription factor cr53). [swissprot;acc:o14771]	269.954	278.217
1073	ww domain binding protein 2 (wbp-2). [swissprot;acc:q969t9]	216.901	210.485	1.03048
1074	coatomer beta' subunit (beta'-coat protein) (beta'-cop) (p102). [swissprot;acc:p35606]	174.387	179.697	1.03045
1075	coatomer gamma subunit (gamma-coat protein) (gamma-cop). [swissprot;acc:q9y678]
1076	coatomer zeta-1 subunit (zeta-1 coat protein) (zeta-1 cop) (cgi-120) (hspc181). [swissprot;acc:q9y3c3]
1077	coatomer delta subunit (delta-coat protein) (delta-cop) (archain). [swissprot;acc:p48444]
1078	peptidyl-prolyl cis-trans isomerase e (ec 5.2.1.8) (ppiase e) (rotamase e) (cyclophilin e) (cyclophilin 33). [swissprot;acc:q9unp9]
1079	coatomer zeta-2 subunit (zeta-2 coat protein) (zeta-2 cop). [swissprot;acc:q9p299]
1080	zinc finger protein 444; endothelial zinc finger protein 2. [refseq;acc:nm_018337]	269.896	278.093	1.03037
1081	40s ribosomal protein s30. [swissprot;acc:q05472]	223.44	216.875	1.03027
1082	phafin 2; ph and fyve domain-containing protein 2. [refseq;acc:nm_024613]	220.118	213.685	1.03011
1083	3-oxo-5-alpha-steroid 4-dehydrogenase 1 (ec 1.3.99.5) (steroid 5-alpha-reductase 1) (sr type 1) (s5ar). [swissprot;acc:p18405]
1084	3-oxo-5-alpha-steroid 4-dehydrogenase 2 (ec 1.3.99.5) (steroid 5-alpha-reductase 2) (sr type 2) (5 alpha-sr2). [swissprot;acc:p31213]
1085	dyskerin (nucleolar protein nap57) (cbf5 homolog). [swissprot;acc:o60832]	231.007	237.864	1.02968
1086	similar to zinc finger protein 277. [sptrembl;acc:q8wwa6]	236.679	243.679	1.02958
1087	zinc finger protein 277. [swissprot;acc:q9nrm2]
1088	annexin a11 (annexin xi) (calcyclin-associated annexin 50) (cap-50) (56 kda autoantigen). [swissprot;acc:p50995]	219.673	213.378	1.0295
1089	cleavage stimulation factor subunit 3; cleavage stimulation factor, 3' pre-rna, subunit 3, 77kd. [refseq;acc:nm_001326]	121.428	125.004	1.02945
1090	similar to ribosomal protein, large, p0. [sptrembl;acc:q96fq9]	226.218	232.88
1091	block 23. [sptrembl;acc:q8nhw5]	226.205	232.858	1.02941
1092	60s acidic ribosomal protein p0 (l10e). [swissprot;acc:p05388]	226.203	232.855
1093	coatomer alpha subunit (alpha-coat protein) (alpha-cop) (hepcop) (hep-cop) [contains: xenin (xenopsin-related peptide); proxenin]. [swissprot;acc:p53621]	177.432	182.647	1.02939
1094	annexin a7 (annexin vii) (synexin). [swissprot;acc:p20073]	219.655	213.385	1.02938
1095	mitochondrial gtp binding protein isoform v. [refseq;acc:nm_032620]	213.552	207.463	1.02935
1096	nadh-ubiquinone oxidoreductase b22 subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b22) (ci-b22). [swissprot;acc:q9y6m9]	212.345	206.339	1.02911
1097	probable calcium-transporting atpase kiaa0703 (ec 3.6.3.8). [swissprot;acc:o75185]	209.123	203.208
1098	adapter-related protein complex 3 mu 1 subunit (mu-adaptin 3a) (ap-3 adapter complex mu3a subunit). [swissprot;acc:q9y2t2]	217.323	211.185	1.02906
1099	adapter-related protein complex 3 mu 2 subunit (clathrin coat assembly protein ap47 homolog 2) (clathrin coat associated protein ap47 homolog 2) (golgi adaptor ap-1 47 kda protein homolog 2) (ha1 47 kda subunit homolog 2) (clathrin assembly protein assembly protein complex 1 medium chain homolog 2) (p47b). [swissprot;acc:p53677]	217.315	211.183	1.02904
1100	calcium-transporting atpase type 2c, member 1 (ec 3.6.3.8) (atpase 2c1) (atp-dependent ca(2+) pump pmr1) (hussy-28). [swissprot;acc:p98194]	209.052	203.183	1.02889

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.