MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Gene	Rank	Value Type	Network Comparison Type	description	Interaction Map	Filtered	network_comparison	red	green

Results: HTML CSV LaTeX

Showing element 1001 to 1050 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	Value Type	Network Comparison Type	description	network_comparison	red	green
126	Measured	Divided	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	1.33499	24250	18164.9
		Subtracted	rad50-interacting protein 1. [refseq;acc:nm_021930]	1944	450.5	2394.5
	Ranked	Divided	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	1.21277	94	114
		Subtracted	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	33.45	285.684	252.234
	Squared	Divided	serine/threonine protein phosphatase pp1-alpha 1 catalytic subunit (ec 3.1.3.16) (pp-1a). [swissprot;acc:p08129]	1.52616	189976	124480
		Subtracted	aquaporin-cd (aqp-cd) (water channel protein for renal collecting duct) (adh water channel) (aquaporin 2) (collecting duct water channel protein) (wch-cd). [swissprot;acc:p41181]	24646	71387.4	96033.4
	Rooted	Divided	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	1.23311	60.9342	75.1387
		Subtracted	high-mobility group 20a. [refseq;acc:nm_018200]	14.1587	60.9353	75.094
127	Measured	Divided	transcription factor jun-d. [swissprot;acc:p17535]	1.33436	5638.2	7523.39
		Subtracted	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	1944	450.5	2394.5
	Ranked	Divided	putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453]	1.21277	94	114
		Subtracted	cullin homolog 2 (cul-2). [swissprot;acc:q13617]	33.45	285.684	252.234
	Squared	Divided	cyclin-dependent kinases regulatory subunit 1 (cks-1) (sid1334) (pnas-16 / pnas-143). [swissprot;acc:p33551]	1.51365	88432.6	58423.3
		Subtracted	lens fiber major intrinsic protein (mip26) (mp26) (aquaporin 0). [swissprot;acc:p30301]	24645.6	71386.9	96032.5
	Rooted	Divided	high-mobility group 20a. [refseq;acc:nm_018200]	1.23236	60.9353	75.094
		Subtracted	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	13.58	153.191	166.771
128	Measured	Divided	luc7-like 2; cgi-74 protein; cgi-59 protein. [refseq;acc:nm_016019]	1.3341	4355.61	5810.82
		Subtracted	t-complex protein 1, alpha subunit (tcp-1-alpha) (cct-alpha). [swissprot;acc:p17987]	1940	11004.2	12944.2
	Ranked	Divided	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]	1.21277	94	114
		Subtracted	presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]	33.45	285.684	252.234
	Squared	Divided	pnas-18. [sptrembl;acc:q9bzu3]	1.50952	87787.3	58155.8
		Subtracted	aquaporin-chip (water channel protein for red blood cells and kidney proximal tubule) (aquaporin 1) (aqp-1) (urine water channel). [swissprot;acc:p29972]	24618.5	71346.6	95965.1
	Rooted	Divided	tar dna-binding protein-43 (tdp-43). [swissprot;acc:q13148]	1.23069	48.0515	39.0445
		Subtracted	nucleolysin tia-1 (rna-binding protein tia-1) (p40-tia-1) [contains: p15-tia-1]. [swissprot;acc:p31483]	13.3216	54.6527	67.9743
129	Measured	Divided	luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032]	1.33348	4358.13	5811.49
		Subtracted	protein phosphatase 1, regulatory (inhibitor) subunit 13b; apoptosis-stimulating protein of p53, 1. [refseq;acc:nm_015316]	1928	15274.9	13346.9
	Ranked	Divided	neuroendocrine differentiation factor; comparative gene identification transcript 149. [refseq;acc:nm_016079]	1.21277	94	114
		Subtracted	cullin homolog 1 (cul-1). [swissprot;acc:q13616]	33.45	285.684	252.234
	Squared	Divided	pre-mrna cleavage complex ii protein pcf11 (fragment). [swissprot;acc:o94913]	1.50257	178263	118639
		Subtracted	translocon-associated protein, delta subunit precursor (trap-delta) (signal sequence receptor delta subunit) (ssr-delta). [swissprot;acc:p51571]	24426.5	71062.4	95488.9
	Rooted	Divided	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]	1.23044	54.2343	66.7323
		Subtracted	nucleolysin tiar (tia-1 related protein). [swissprot;acc:q01085]	13.2852	54.6625	67.9477
130	Measured	Divided	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]	1.33287	2234.68	2978.53
		Subtracted	p66 alpha. [refseq;acc:nm_017660]	1927.9	12839	10911.1
	Ranked	Divided	protein hspc134 (protein cda04). [swissprot;acc:q9by43]	1.21277	94	114
		Subtracted	palmitoyl-protein thioesterase 2 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 2) (ppt-2) (g14). [swissprot;acc:q9umr5]	33.324	242.735	276.059
	Squared	Divided	44050 protein. [refseq;acc:nm_178832]	1.4861	148058	99628.4
		Subtracted	calsyntenin-1 precursor. [swissprot;acc:o94985]	24426.5	71062.4	95488.9
	Rooted	Divided	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	1.22626	55.1026	67.5701
		Subtracted	ras-related gtp binding a; ras-related gtp-binding protein. [refseq;acc:nm_006570]	13.218	144.606	157.824
131	Measured	Divided	forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	1.33285	2234.73	2978.57
		Subtracted	transcription repressor p66 beta component of the mecp1 complex. [refseq;acc:nm_020699]	1927.9	12839	10911.1
	Ranked	Divided	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]	1.21228	294.053	242.562
		Subtracted	egf-like-domain, multiple 7; neu1 protein. [refseq;acc:nm_016215]	33.3	242.718	276.018
	Squared	Divided	nuclear inhibitor of protein phosphatase-1 (nipp-1) (protein phosphatase 1, regulatory inhibitor subunit 8) [includes: activator of rna decay (ec 3.1.4.-) (ard-1)]. [swissprot;acc:q12972]	1.4861	148058	99628.4
		Subtracted	succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor (cybs) (succinate-ubiquinone reductase membrane anchor subunit) (qps2) (cii-4) (succinate dehydrogenase complex subunit d) (succinate-ubiquinone oxidoreductase cytochrome b small subunit). [swissprot;acc:o14521]	24426.5	71062.4	95488.9
	Rooted	Divided	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	1.22577	55.1113	67.5537
		Subtracted	ras-related gtp binding c; rag c protein. [refseq;acc:nm_022157]	13.218	144.606	157.824
132	Measured	Divided	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]	1.33253	2236.61	2980.35
		Subtracted	tyrosine aminotransferase (ec 2.6.1.5) (l-tyrosine:2-oxoglutarate aminotransferase) (tat). [swissprot;acc:p17735]	1927.9	12839	10911.1

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.