MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Network Comparison Type	Gene	Rank	Value Type	Interaction Map	description	red	Filtered	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1001 to 1050 of 25824 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Value Type	description	red	network_comparison	green
251	Measured	tyrosine-protein kinase hck (ec 2.7.1.112) (p59-hck/p60-hck) (hemopoietic cell kinase). [swissprot;acc:p08631]	6417.18	1.22477	7859.6
	Ranked	oligopeptide transporter, small intestine isoform (peptide transporter 1) (intestinal h+/peptide cotransporter) (solute carrier family 15, member 1). [swissprot;acc:p46059]	186.172	1.11707	166.661
	Squared	b-cell cll/lymphoma 6, member b (zinc finger protein); zinc finger protein 62. [refseq;acc:nm_181844]	69165.6	1.30521	52992.1
	Rooted	max protein. [swissprot;acc:p25912]	56.3054	1.13159	63.7148
252	Measured	crk-like protein. [swissprot;acc:p46109]	6417.18	1.22477	7859.6
	Ranked	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]	237.292	1.11689	212.457
	Squared	pas domain containing serine/threonine kinase; pas-serine/threonine kinase. [refseq;acc:nm_015148]	69165	1.3052	52991.7
	Rooted	nuclear transcription factor y subunit beta (nf-y protein chain b) (nf-yb) (ccaat-binding transcription factor subunit a) (cbf-a) (caat- box dna binding protein subunit b). [swissprot;acc:p25208]	51.6736	1.13099	58.4422
253	Measured	proto-oncogene tyrosine-protein kinase abl1 (ec 2.7.1.112) (p150) (c-abl). [swissprot;acc:p00519]	6417.18	1.22477	7859.59
	Ranked	mad protein (max dimerizer). [swissprot;acc:q05195]	228	1.11583	204.333
	Squared	b-cell lymphoma 6 protein (bcl-6) (zinc finger protein 51) (laz-3 protein) (bcl-5). [swissprot;acc:p41182]	69165	1.3052	52991.7
	Rooted	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	53.5956	1.12817	60.465
254	Measured	proto-oncogene tyrosine-protein kinase fyn (ec 2.7.1.112) (p59-fyn) (syn) (slk). [swissprot;acc:p06241]	6417.18	1.22477	7859.6
	Ranked	source of immunodominant mhc-associated peptides; homolog of yeast stt3 gene. [refseq;acc:nm_178862]	200.691	1.11569	179.88
	Squared	zinc finger protein slug (neural crest transcription factor slug) (snail homolog 2). [swissprot;acc:o43623]	69165	1.3052	52991.7
	Rooted	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	53.607	1.12756	60.4452
255	Measured	proto-oncogene tyrosine-protein kinase fgr (ec 2.7.1.112) (p55-fgr) (c-fgr). [swissprot;acc:p09769]	6417.18	1.22477	7859.6
	Ranked	oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977]	200.691	1.11569	179.88
	Squared	c-terminal binding protein 1 (ctbp1). [swissprot;acc:q13363]	69123.3	1.30503	52967
	Rooted	ribonucleoside-diphosphate reductase m2 chain (ec 1.17.4.1) (ribonucleotide reductase small chain). [swissprot;acc:p31350]	62.9007	1.12694	70.8854
256	Measured	grb2-related adaptor protein 2 (gads protein) (growth factor receptor binding protein) (grblg) (grf40 adaptor protein) (grf-40) (grb-2-like protein) (grb2l) (grbx) (p38) (hematopoietic cell-associated adaptor protein grpl) (adapter protein grid) (sh3-sh2-sh3 adaptor mona). [swissprot;acc:o75791]	6417.19	1.22476	7859.51
	Ranked	max interacting protein 1 (mxi1 protein). [swissprot;acc:p50539]	227.999	1.11569	204.357
	Squared	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	15465.1	1.303	20151
	Rooted	ccaat-box-binding transcription factor (ccaat-binding factor) (cbf). [swissprot;acc:q03701]	48.0045	1.12665	54.0843
257	Measured	ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880]	6417.31	1.22452	7858.12
	Ranked	dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kda subunit precursor (ec 2.4.1.119) (oligosaccharyl transferase 48 kda subunit) (ddost 48 kda subunit). [swissprot;acc:p39656]	200.691	1.11569	179.88
	Squared	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	15482.3	1.30229	20162.4
	Rooted	cartilage oligomeric matrix protein precursor (comp). [swissprot;acc:p49747]	51.6125	1.12591	45.8409
258	Measured	homeobox protein cux-2 (cut-like 2) (fragment). [swissprot;acc:o14529]	6417.33	1.22449	7857.93
	Ranked	max-interacting transcriptional repressor mad4 (max-associated protein 4) (max dimerization protein 4). [swissprot;acc:q14582]	227.999	1.11564	204.366
	Squared	huntingtin interacting protein 1 (hip-i). [swissprot;acc:o00291]	76438	1.29799	58889.7
	Rooted	thrombospondin 3 precursor. [swissprot;acc:p49746]	51.6132	1.12589	45.8422
259	Measured	neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401]	6417.81	1.22355	7852.52
	Ranked	max dimerization protein 3; likely ortholog of mouse max dimerization protein 3. [refseq;acc:nm_031300]	227.999	1.11562	204.37
	Squared	goodpasture antigen-binding protein (ec 2.7.1.37) (gpbp) (collagen type iv alpha 3 binding protein) (star-related lipid transfer protein 11) (stard11) (start domain-containing protein 11). [swissprot;acc:q9y5p4]	76360.8	1.29773	58841.7
	Rooted	tuftelin-interacting protein 11 (hspc006). [swissprot;acc:q9ubb9]	58.2964	1.12516	65.5926
260	Measured	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	4244.95	1.22343	5193.42
	Ranked	c439a6.1 (novel protein similar to heparan sulfate (glucosamine) 3-o- sulfotransferases) (fragment). [sptrembl;acc:q96qi5]	219.421	1.11394	196.978
	Squared	huntingtin interacting protein 1 related (hip1-related) (hip 12). [swissprot;acc:o75146]	76296.4	1.29752	58801.6
	Rooted	multisynthetase complex auxiliary component p43 [contains: endothelial-monocyte activating polypeptide ii (emap-ii) (small inducible cytokine subfamily e member 1)]. [swissprot;acc:q12904]	59.0951	1.12417	66.4332
261	Measured	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	4247.36	1.22255	5192.61
	Ranked	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3a1; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006042]	219.421	1.11394	196.978
	Squared	pyruvate carboxylase, mitochondrial precursor (ec 6.4.1.1) (pyruvic carboxylase) (pcb). [swissprot;acc:p11498]	48127.9	1.29334	62245.6
	Rooted	ribonucleotide reductase m2 b (tp53 inducible); p53-inducible ribonucleotide reductase small subunit 2 homolog. [refseq;acc:nm_015713]	62.3337	1.12417	70.0738
262	Measured	cleavage and polyadenylation specific factor 4, 30kd subunit; cleavage-polyadenylation specificity factor, 30kd; no arches-like (zebrafish) zinc finger protein; cleavage-polyadenylation specificity factor. [refseq;acc:nm_006693]	24896.4	1.21852	20431.7
	Ranked	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3b1. [refseq;acc:nm_006041]	219.421	1.11394	196.978
	Squared	neuronal acetylcholine receptor protein, alpha-7 chain precursor. [swissprot;acc:p36544]	26157.6	1.29261	20236.2
	Rooted	polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195]	59.4073	1.12276	66.7002
263	Measured	trs85 homolog. [swissprot;acc:q9y2l5]	24896.4	1.21852	20431.7
	Ranked	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 2; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006043]	219.421	1.11394	196.978

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.