Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Gene Rank Network Comparison Type Value Type description Interaction Map red Filtered network_comparison green
Results: HTML CSV LaTeX Showing element 101 to 150 of 6456 in total
Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1
Rank
Network Comparison Type
description
red
network_comparison
green
51 Divided neurogenic differentiation factor 4 (neurod4). [swissprot;acc:q9hd90] 779.167 1.78438 1390.33
Subtracted fip1-like 1; rearranged in hypereosinophilia. [refseq;acc:nm_030917] 23640.2 4160.4 19479.8
52 Divided chromodomain helicase dna binding protein 5. [refseq;acc:nm_015557] 779.167 1.78438 1390.33
Subtracted cleavage and polyadenylation specificity factor, 73 kda subunit (cpsf 73 kda subunit). [swissprot;acc:q9ukf6] 23422.4 4042.1 19380.3
53 Divided cyclin-dependent kinase 2-associated protein 1 (cdk2-associated protein 1) (putative oral cancer suppressor) (deleted in oral cancer- 1) (doc-1). [swissprot;acc:o14519] 779.167 1.78438 1390.33
Subtracted poly(a) polymerase alpha (ec 2.7.7.19) (pap) (polynucleotide adenylyltransferase alpha) (fragment). [swissprot;acc:p51003] 23326.5 4030.1 19296.4
54 Divided deltex 2. [refseq;acc:nm_020892] 1618.84 1.63814 2651.88
Subtracted exocyst complex component sec5. [swissprot;acc:q96kp1] 23316 4027.2 19288.8
55 Divided deltex homolog 1; hdx-1. [refseq;acc:nm_004416] 1629.21 1.63399 2662.12
Subtracted poly(a) polymerase gamma (ec 2.7.7.19) (pap gamma) (polynucleotide adenylyltransferase gamma) (srp rna 3' adenylating enzyme). [swissprot;acc:q9bwt3] 23303.1 4023.6 19279.5
56 Divided t-lak cell-originated protein kinase; spermatogenesis-related protein kinase; pdz-binding kinase; pbk; mapkk-like protein kinase; serine/threonine protein kinase. [refseq;acc:nm_018492] 1631.67 1.63302 2664.55
Subtracted ras-related gtp binding a; ras-related gtp-binding protein. [refseq;acc:nm_006570] 20911 3997.5 24908.5
57 Divided kh domain containing, rna binding, signal transduction associated 3; sam68-like phosphotyrosine protein, t-star. [refseq;acc:nm_006558] 1631.67 1.63302 2664.55
Subtracted ras-related gtp binding c; rag c protein. [refseq;acc:nm_022157] 20911 3997.5 24908.5
58 Divided kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559] 1631.67 1.63302 2664.55
Subtracted ras-related gtp binding b short isoform; gtp-binding protein ragb. [refseq;acc:nm_006064] 20911 3997.5 24908.5
59 Divided kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688] 1631.67 1.63302 2664.55
Subtracted anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685] 20911 3997.5 24908.5
60 Divided 1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446] 4489.19 1.6231 2765.82
Subtracted ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395] 16771.5 3882.4 12889.1
61 Divided glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216] 4489.19 1.6231 2765.82
Subtracted beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121] 6475.5 3832 10307.5
62 Divided glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737] 4489.19 1.6231 2765.82
Subtracted beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407] 6475.5 3832 10307.5
63 Divided myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7] 4489.19 1.6231 2765.82
Subtracted spermatogenesis associated 6. [refseq;acc:nm_019073] 6475.5 3832 10307.5
64 Divided glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217] 4489.19 1.6231 2765.82
Subtracted amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433] 6475.5 3832 10307.5
65 Divided neuralized-like. [refseq;acc:nm_004210] 1657.68 1.6229 2690.25
Subtracted cleavage stimulation factor subunit 3; cleavage stimulation factor, 3' pre-rna, subunit 3, 77kd. [refseq;acc:nm_001326] 22515.5 3812.9 18702.6
66 Divided nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09] 1991.03 1.61795 3221.38
Subtracted a-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (a-raf-1) (proto-oncogene pks). [swissprot;acc:p10398] 17757.5 3749.5 14008
67 Divided beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121] 6475.5 1.59177 10307.5
Subtracted raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (raf-1) (c-raf). [swissprot;acc:p04049] 17756.5 3749.2 14007.3
68 Divided beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407] 6475.5 1.59177 10307.5
Subtracted cyclin g2. [swissprot;acc:q16589] 17738.6 3742.9 13995.7
69 Divided spermatogenesis associated 6. [refseq;acc:nm_019073] 6475.5 1.59177 10307.5
Subtracted cyclin g1 (cyclin g). [swissprot;acc:p51959] 17738.5 3742.9 13995.6
70 Divided amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433] 6475.5 1.59177 10307.5
Subtracted serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, epsilon isoform (pp2a, b subunit, b' epsilon isoform) (pp2a, b subunit, b56 epsilon isoform) (pp2a, b subunit, pr61 epsilon isoform) (pp2a, b subunit, r5 epsilon isoform). [swissprot;acc:q16537] 17738.5 3742.8 13995.7
71 Divided serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, alpha isoform (pp2a, subunit b, b-alpha isoform) (pp2a, subunit b, b55-alpha isoform) (pp2a, subunit b, pr55-alpha isoform) (pp2a, subunit b, r2-alpha isoform). [swissprot;acc:q00007] 4556.78 1.54716 2945.26
Subtracted serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, alpha isoform (pp2a, b subunit, b' alpha isoform) (pp2a, b subunit, b56 alpha isoform) (pp2a, b subunit, pr61 alpha isoform) (pp2a, b subunit, r5 alpha isoform). [swissprot;acc:q15172] 17738.5 3742.8 13995.7
72 Divided uncharacterized hematopoietic stem/progenitor cells protein mds026. [sptrembl;acc:q9nz48] 4556.79 1.54715 2945.28
Subtracted b-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (p94) (v-raf murine sarcoma viral oncogene homolog b1). [swissprot;acc:p15056] 17710.9 3733.2 13977.7
73 Divided serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, beta isoform (pp2a, subunit b, b-beta isoform) (pp2a, subunit b, b55- beta isoform) (pp2a, subunit b, pr55-beta isoform) (pp2a, subunit b, r2-beta isoform). [swissprot;acc:q00005] 4556.83 1.54711 2945.38
Subtracted serine/threonine protein phosphatase pp1-gamma catalytic subunit (ec 3.1.3.16) (pp-1g). [swissprot;acc:p36873] 22268.8 3708.4 18560.4
74 Divided serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, gamma isoform (pp2a, subunit b, b-gamma isoform) (pp2a, subunit b, b55-gamma isoform) (pp2a, subunit b, pr55-gamma isoform) (pp2a, subunit b, r2-gamma isoform) (imypno1). [swissprot;acc:q9y2t4] 4556.99 1.54694 2945.8
Subtracted homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017] 20446.1 3690.3 24136.4
75 Divided nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181] 1920.75 1.5137 2907.43
Subtracted homeobox protein hox-b4 (hox-2f) (hox-2.6). [swissprot;acc:p17483] 20446.1 3690.3 24136.4

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/