MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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description	Rank	Gene	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 101 to 150 of 7460 in total

Value Type  : Ranked
Interaction Map  : High confidence

description	Rank	Network Comparison Type	Filtered	red	green	network_comparison
28s ribosomal protein s9, mitochondrial precursor (mrp-s9). [swissprot;acc:p82933]	340	Subtracted	1	239.75	260.544	20.794
	407	Divided				1.08673
3 beta-hydroxy-delta 5-c27-steroid oxidoreductase. [refseq;acc:nm_025193]	3147			0.00001	0.00001	1
		Subtracted		0	0	0
3 beta-hydroxysteroid dehydrogenase (fragments). [sptrembl;acc:q9udk8]	284		0	12338.7	11512.3	826.4
	299	Divided				1.07178
	2756		1	0.00001	0.00001	1
		Subtracted		0	0	0
3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type i (3beta-hsd i) (trophoblast antigen fdo161g) [includes: 3-beta-hydroxy- delta(5)-steroid dehydrogenase (ec 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (progesterone reductase); steroid delta- isomerase (ec 5.3.3.1) (delta-5-3-ketosteroid isomerase)]. [swissprot;acc:p14060]	2802	Divided		0.00001	0.00001	1
		Subtracted		0	0	0
3-hydroxy-3-methylglutaryl-coenzyme a reductase (ec 1.1.1.34) (hmg-coa reductase). [swissprot;acc:p04035]	2303	Divided		191.567	192.542	1.00509
	2333	Subtracted				0.975
3-hydroxyacyl-coa dehydrogenase type ii (ec 1.1.1.35) (type ii hadh) (endoplasmic reticulum-associated amyloid beta-peptide binding protein) (short-chain type dehydrogenase/reductase xh98g2). [swissprot;acc:q99714]	3180	Divided		0.00001	0.00001	1
		Subtracted		0	0	0
3-hydroxyanthranilate 3,4-dioxygenase (ec 1.13.11.6) (3-hao) (3-hydroxyanthranilic acid dioxygenase) (3-hydroxyanthranilate oxygenase). [swissprot;acc:p46952]	2189	Divided		209.54	208.162	1.00662
	2201	Subtracted				1.378
3-hydroxyisobutyryl-coenzyme a hydrolase. [refseq;acc:nm_014362]	327	Divided	0	9897.29	10466.5	1.05751
	348	Subtracted				569.21
	1852	Divided	1	196.008	198.154	1.01095
	1914	Subtracted				2.146
3-ketoacyl-coa thiolase, peroxisomal precursor (ec 2.3.1.16) (beta- ketothiolase) (acetyl-coa acyltransferase) (peroxisomal 3-oxoacyl- coa thiolase). [swissprot;acc:p09110]	473		0	10156.4	10243.1	86.7
	478	Divided				1.00854
	2300		1	191.563	192.541	1.00511
	2331	Subtracted				0.978
3-mercaptopyruvate sulfurtransferase (ec 2.8.1.2) (mst). [swissprot;acc:p25325]	1025	Divided		205.632	199.266	1.03195
	1048	Subtracted				6.366
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (ec 1.3.99.5) (steroid 5-alpha-reductase 1) (sr type 1) (s5ar). [swissprot;acc:p18405]	1040			220.118	213.685	6.433
	1083	Divided				1.03011
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (ec 1.3.99.5) (steroid 5-alpha-reductase 2) (sr type 2) (5 alpha-sr2). [swissprot;acc:p31213]	1041	Subtracted				6.433
	1084	Divided				1.03011
3-phosphoinositide dependent protein kinase-1 (ec 2.7.1.37) (hpdk1). [swissprot;acc:o15530]	739	Subtracted		272.878	283.472	10.594
	897	Divided				1.03882
38 kda fk-506 binding protein homolog (fkbpr38) (fk506-binding protein 8). [swissprot;acc:q14318]	2358			198.181	197.346	1.00423
	2385	Subtracted				0.835
4-aminobutyrate aminotransferase, mitochondrial precursor (ec 2.6.1.19) (gamma-amino-n-butyrate transaminase) (gaba transaminase) (gaba aminotransferase) (gaba-at) (gaba-t). [swissprot;acc:p80404]	277		0	18849.7	19704.7	855
	369	Divided				1.04536
	1720	Subtracted	1	219.423	222.215	2.792
	1745	Divided				1.01272
40s ribosomal protein s11. [swissprot;acc:p04643]	199	Subtracted		241.399	267.088	25.689
	278	Divided				1.10642
40s ribosomal protein s13. [swissprot;acc:q02546]	1695	Subtracted		220.899	223.813	2.914
	1722	Divided				1.01319
40s ribosomal protein s14 (pro2640). [swissprot;acc:p06366]	323	Subtracted		242.238	264.11	21.872
	386	Divided				1.09029
40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174]	205	Subtracted	0	12183	11013.2	1169.8
	219		1	242.339	266.986	24.647
	222	Divided	0	12183	11013.2	1.10622
	304		1	242.339	266.986	1.1017
40s ribosomal protein s15a. [swissprot;acc:p39027]	206	Subtracted		241.411	266.414	25.003
	292	Divided				1.10357

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.