Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene Value Type Rank Network Comparison Type description Interaction Map green Filtered red network_comparison

Results: HTML CSV LaTeX

Showing element 101 to 150 of 7460 in total

Value Type

: Ranked
Interaction Map

: High confidence

Rank	Network Comparison Type	description	green	Filtered	red	network_comparison
26	Divided	dystrobrevin binding protein 1; dysbindin. [refseq;acc:nm_032122]	7533.33	0	12128.3	1.60995
	Divided	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	44	1	58	1.31818
	Subtracted	microtubule-associated protein, rp/eb family, member 2; t-cell activation protein, eb1 family; apc-binding protein eb1. [refseq;acc:nm_014268]	17173.8	0	11284	5889.8
	Subtracted	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	253	1	322	69
27	Divided	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	44	1	58	1.31818
	Divided	ptd016 protein. [refseq;acc:nm_016125]	11234	0	18050	1.60673
	Subtracted	60s ribosomal protein l37a. [swissprot;acc:p12751]	18499.2	0	12941.7	5557.5
	Subtracted	guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]	336.077	1	267.136	68.941
28	Divided	cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]	153.671	1	201.949	1.31416
	Divided	p28 ing5. [refseq;acc:nm_032329]	7562.05	0	12124.8	1.60337
	Subtracted	25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	18499.2	0	12941.7	5557.5
	Subtracted	guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992]	336.077	1	267.136	68.941
29	Divided	phenylethanolamine n-methyltransferase (ec 2.1.1.28) (pnmtase) (noradrenaline n-methyltransferase). [swissprot;acc:p11086]	11625	0	7395	1.57201
	Divided	uncharacterized hematopoietic stem/progenitor cells protein mds026. [sptrembl;acc:q9nz48]	243.678	1	187.458	1.29991
	Subtracted	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	8257	0	13730.5	5473.5
	Subtracted	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	336.075	1	267.139	68.936
30	Divided	beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938]	11625	0	7395	1.57201
	Divided	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, alpha isoform (pp2a, subunit b, b-alpha isoform) (pp2a, subunit b, b55-alpha isoform) (pp2a, subunit b, pr55-alpha isoform) (pp2a, subunit b, r2-alpha isoform). [swissprot;acc:q00007]	243.678	1	187.457	1.29991
	Subtracted	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	336.075	1	267.14	68.935
	Subtracted	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]	8257	0	13730.5	5473.5
31	Divided	leucine rich repeat (in flii) interacting protein 1. [refseq;acc:nm_004735]	5266.67	0	8082.33	1.53462
	Divided	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, beta isoform (pp2a, subunit b, b-beta isoform) (pp2a, subunit b, b55- beta isoform) (pp2a, subunit b, pr55-beta isoform) (pp2a, subunit b, r2-beta isoform). [swissprot;acc:q00005]	243.677	1	187.458	1.2999
	Subtracted	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]	336.075	1	267.14	68.935
	Subtracted	potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110]	6248	0	11627	5379
32	Divided	importin 9. [refseq;acc:nm_018085]	8691.76	0	13292.2	1.52929
	Divided	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, gamma isoform (pp2a, subunit b, b-gamma isoform) (pp2a, subunit b, b55-gamma isoform) (pp2a, subunit b, pr55-gamma isoform) (pp2a, subunit b, r2-gamma isoform) (imypno1). [swissprot;acc:q9y2t4]	243.673	1	187.462	1.29985
	Subtracted	guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899]	336.074	1	267.142	68.932
	Subtracted	syntaxin 10 (syn10). [swissprot;acc:o60499]	19014.6	0	13884.4	5130.2
33	Divided	nucleosome assembly protein 1-like 4 (nucleosome assembly protein 2) (nap2). [swissprot;acc:q99733]	8691.76	0	13292.2	1.52929
	Divided	serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, beta isoform (pp2a, subunit a, pr65-beta isoform) (pp2a, subunit a, r1-beta isoform). [swissprot;acc:p30154]	242.742	1	188.688	1.28647
	Subtracted	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]	336.073	1	267.144	68.929
	Subtracted	similar to lysozyme c-1 (1,4-beta-n-acylmuramidase c, ec 3.2.1.17). [refseq;acc:nm_032517]	20387	0	15264	5123
34	Divided	microtubule-associated protein, rp/eb family, member 2; t-cell activation protein, eb1 family; apc-binding protein eb1. [refseq;acc:nm_014268]	17173.8	0	11284	1.52196
	Divided	serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, alpha isoform (pp2a, subunit a, pr65-alpha isoform) (pp2a, subunit a, r1-alpha isoform) (medium tumor antigen-associated 61 kda protein). [swissprot;acc:p30153]	242.453	1	189.07	1.28235
	Subtracted	fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402]	6812	0	11543	4731
	Subtracted	guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]	336.073	1	267.144	68.929
35	Divided	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	4871.6	0	3208.8	1.5182
	Divided	nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952]	204.309	1	260.532	1.27519
	Subtracted	guanine nucleotide-binding protein beta subunit 5 (transducin beta chain 5). [swissprot;acc:o14775]	335.359	1	267.636	67.723
	Subtracted	importin 9. [refseq;acc:nm_018085]	8691.76	0	13292.2	4600.44
36	Divided	ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]	204.309	1	260.532	1.27519
	Divided	guanine nucleotide-binding protein beta subunit-like protein 1 (g protein beta-subunit like protein 1) (wd40 repeat containing protein deleted in vcfs) (wdvcf protein) (fksg1 protein) (dgcrk3). [swissprot;acc:q9byb4]	14964	0	22422	1.4984
	Subtracted	nucleosome assembly protein 1-like 4 (nucleosome assembly protein 2) (nap2). [swissprot;acc:q99733]	8691.76	0	13292.2	4600.44
	Subtracted	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	254.434	1	320.927	66.493
37	Divided	dj570f3.6 (novel protein similar to lysophospholipase ii (lypla2)). [sptrembl;acc:q9uge0]	2582	0	3859	1.49458
	Divided	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	253	1	322	1.27273
	Subtracted	dystrobrevin binding protein 1; dysbindin. [refseq;acc:nm_032122]	7533.33	0	12128.3	4594.97
	Subtracted	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901]	333.165	1	266.716	66.449
38	Divided	cell division protein kinase 8 (ec 2.7.1.-) (protein kinase k35). [swissprot;acc:p49336]	10771	0	7230	1.48976
38	Divided	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	253	1	322	1.27273

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.

- http://analysis.yellowcouch.org/