Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Gene Rank description Network Comparison Type Value Type Interaction Map Filtered green network_comparison red
Results: HTML CSV LaTeX Showing element 101 to 150 of 25824 in total
Interaction Map  : High confidence
Filtered  : 1
Rank
description
Network Comparison Type
Value Type
green
network_comparison
red
13 guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6] Subtracted Ranked 336.233 69.377 266.856
melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364] Squared 129762 89286 219048
myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0] Measured 27904.5 6313 21591.5
protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8] Divided Ranked 212.554 1.3585 288.754
14 cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936] 75.3531 1.32952 56.6768
guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150] Subtracted 336.191 69.328 266.863
melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356] Squared 129762 89286 219048
myosin vc (myosin 5c). [swissprot;acc:q9nqx4] Measured 27904.5 6313 21591.5
ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2] Divided 1281.5 3.21581 398.5
Squared 388.696 10.3414 37.5863
Rooted 35.798 1.79326 19.9625
spermatogenesis associated 6. [refseq;acc:nm_019073] Subtracted 101.526 21.0555 80.4705
15 amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]
gbp protein isoform a. [refseq;acc:nm_017870] Divided 42.4773 1.77158 23.9771
guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798] Subtracted Ranked 336.19 69.327 266.863
hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932] Squared 129762 89286 219048
microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8] Divided Ranked 75.3948 1.32914 56.7244
myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1] Subtracted Measured 27904.5 6313 21591.5
xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266] Divided 871 3.06659 2671
Squared 179.56 9.40399 1688.58
16 cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936] Subtracted Measured 18172.1 6088.2 24260.3
guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08] Ranked 336.184 69.32 266.864
mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476] Rooted 182.638 21.035 203.673
melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360] Squared 129762 89286 219048
microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492] Divided Ranked 75.3954 1.32913 56.7252
protein x 0004. [refseq;acc:nm_016301] Measured 871 3.06659 2671
Squared 179.56 9.40399 1688.58
xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266] Rooted 29.5127 1.75117 51.6817
17 cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326] Ranked 75.447 1.32866 56.7841
cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438] Subtracted Rooted 182.638 21.035 203.673
dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8] Divided Measured 1365 2.96739 460
Squared 441 8.80542 50.0828
guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670] Subtracted Ranked 336.182 69.318 266.864
microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8] Measured 18168.9 6086.8 24255.7
necdin. [swissprot;acc:q99608] Squared 129762 89286 219048
protein x 0004. [refseq;acc:nm_016301] Divided Rooted 29.5127 1.75117 51.6817
18 1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446] Ranked 245.247 1.32082 185.678
cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418] Subtracted Rooted 182.638 21.035 203.673
dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8] Divided 36.9459 1.72261 21.4476
guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151] Subtracted Ranked 336.181 69.316 266.865
melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3] Squared 129762 89286 219048
microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492] Measured 18168.9 6086.8 24255.7
protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256] Divided 1865.5 2.75351 677.5
Squared 823.69 7.58176 108.641
19 cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326] Subtracted Measured 18164.9 6085.1 24250
cytohesin 4. [swissprot;acc:q9uia0] Rooted 182.638 21.035 203.673
glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216] Divided Ranked 245.247 1.32082 185.678
guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8] Subtracted 336.178 69.313 266.865
melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2] Squared 129762 89286 219048
microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083] Divided Measured 1865.5 2.75351 677.5

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/