MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 277 to 326 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	green	red	network_comparison
277	40s ribosomal protein s29. [swissprot;acc:p30054]	267.642	241.849	1.10665
278	40s ribosomal protein s11. [swissprot;acc:p04643]	267.088	241.399	1.10642
279	histone acetyltransferase type b subunit 2 (retinoblastoma binding protein p46) (retinoblastoma-binding protein 7) (rbbp-7). [swissprot;acc:q16576]	228.42	252.644	1.10605
280	metastasis-associated protein mta1. [swissprot;acc:q13330]	228.356	252.512	1.10578
281	60s ribosomal protein l17 (l23). [swissprot;acc:p18621]	267.335	241.808	1.10557
282	chromatin assembly factor 1 subunit c (caf-1 subunit c) (chromatin assembly factor i p48 subunit) (caf-i 48 kda subunit) (caf-ip48) (retinoblastoma binding protein p48) (retinoblastoma-binding protein 4) (rbbp-4) (msi1 protein homolog). [swissprot;acc:q09028]	228.297	252.39	1.10553
283	60s ribosomal protein l11. [swissprot;acc:p39026]	267.346	241.828	1.10552
284	crk-associated substrate (p130cas) (breast cancer anti-estrogen resistance 1 protein). [swissprot;acc:p56945]	203.235	224.657	1.10541
285	t-complex protein 1, delta subunit (tcp-1-delta) (cct-delta) (stimulator of tar rna binding). [swissprot;acc:p50991]	203.242	224.647	1.10532
286	enhancer of filamentation 1 (hef1) (crk-associated substrate-related protein) (cas-l) (casl) (pp105) (neural precursor cell expressed developmentally down-regulated 9). [swissprot;acc:q14511]	203.251	224.633	1.1052
287	40s ribosomal protein s4, y isoform 2. [swissprot;acc:q8td47]	266.079	240.758	1.10517
288	40s ribosomal protein s4, x isoform (single copy abundant mrna protein) (scr10). [swissprot;acc:p12750]	266.078
289	hpaii tiny fragments locus 9c. [refseq;acc:nm_022727]	246.892	272.781	1.10486
290	ribonucleoside-diphosphate reductase m2 chain (ec 1.17.4.1) (ribonucleotide reductase small chain). [swissprot;acc:p31350]	210.064	231.969	1.10428
291	nuclear transcription factor y subunit beta (nf-y protein chain b) (nf-yb) (ccaat-binding transcription factor subunit a) (cbf-a) (caat- box dna binding protein subunit b). [swissprot;acc:p25208]	228.037	251.679	1.10368
292	40s ribosomal protein s15a. [swissprot;acc:p39027]	266.414	241.411	1.10357
293	60s ribosomal protein l23 (l17). [swissprot;acc:p23131]	265.717	240.782	1.10356
294	brca2 and cdkn1a-interacting protein isoform bccipalpha; brca2 and cdkn1a-interacting protein; cdk inhibitor p21 binding protein; bccipalpha; bccipbeta; tok-1alpha; tok-1beta. [refseq;acc:nm_016567]
295	multisynthetase complex auxiliary component p43 [contains: endothelial-monocyte activating polypeptide ii (emap-ii) (small inducible cytokine subfamily e member 1)]. [swissprot;acc:q12904]	202.423	223.273	1.103
296	mitochondrial ribosomal protein l4 isoform a. [refseq;acc:nm_015956]	266.12	241.282	1.10294
297	60s ribosomal protein l7. [swissprot;acc:p18124]	259.984	235.727	1.1029
298	calpain 2, large [catalytic] subunit precursor (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (m-type) (m-calpain) (millimolar-calpain) (calpain large polypeptide l2). [swissprot;acc:p17655]	243.588	268.632	1.10281
299	calpain 1, large [catalytic] subunit (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (mu-type) (mucanp) (micromolar-calpain). [swissprot;acc:p07384]	243.592	268.635
300	metalloprotease 1; metalloprotease 1 (pitrilysin family). [refseq;acc:nm_014889]	166.351	150.959	1.10196
301	beta-1,4 mannosyltransferase. [refseq;acc:nm_019109]	166.372	150.982	1.10193
302	60s ribosomal protein l26. [swissprot;acc:q02877]	267.008	242.326	1.10185
303	60s ribosomal protein l35. [swissprot;acc:p42766]	266.999	242.333	1.10179
304	40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174]	266.986	242.339	1.1017
305	mitochondrial ribosomal protein l2. [refseq;acc:nm_015950]
306	60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914]	266.673	242.153	1.10126
307	serine racemase (ec 5.1.1.-). [swissprot;acc:q9gzt4]
308	60s ribosomal protein l34. [swissprot;acc:p49207]
309	protein transport protein sec61 alpha subunit isoform 2 (sec61 alpha- 2). [swissprot;acc:q9y2r3]
310	protein transport protein sec61 alpha subunit isoform 1 (sec61 alpha- 1). [swissprot;acc:p38378]
311	protein translation factor sui1 homolog gc20. [swissprot;acc:o60739]	267.151	242.627	1.10108
312	60s ribosomal protein l3-like. [swissprot;acc:q92901]	266.663	242.195	1.10103
313	ribonucleotide reductase m2 b (tp53 inducible); p53-inducible ribonucleotide reductase small subunit 2 homolog. [refseq;acc:nm_015713]	211.207	232.473	1.10069
314	methionine aminopeptidase 1 (ec 3.4.11.18) (metap 1) (map 1) (peptidase m 1). [swissprot;acc:p53582]	268.604	244.126	1.10027
315	methionine aminopeptidase 2 (ec 3.4.11.18) (metap 2) (peptidase m 2) (initiation factor 2 associated 67 kda glycoprotein) (p67) (p67eif2). [swissprot;acc:p50579]
316	protein translation factor sui1 homolog (sui1iso1). [swissprot;acc:p41567]	267.017	242.694	1.10022
317	splicing factor 3b subunit 3 (spliceosome associated protein 130) (sap 130) (sf3b130) (pre-mrna splicing factor sf3b 130 kda subunit). [swissprot;acc:q15393]	204.044	224.445	1.09998
318	mitochondrial 60s ribosomal protein l3 (l3mt). [swissprot;acc:p09001]	266.18	242.011	1.09987
319	60s ribosomal protein l19. [swissprot;acc:p14118]	264.729	240.73	1.09969
320	epithelial-cadherin precursor (e-cadherin) (uvomorulin) (cadherin-1) (cam 120/80). [swissprot;acc:p12830]	265.96	241.892	1.0995
321	c367g8.3 (novel protein similar to rpl23a (60s ribosomal protein l23a)) (60s ribosomal protein l23a like). [sptrembl;acc:q9br02]	265.959		1.09949
322	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	78.8995	86.7483	1.09948
323	60s ribosomal protein l23a. [swissprot;acc:p29316]	265.945	241.884	1.09947
324	40s ribosomal protein s23. [swissprot;acc:p39028]	268.195	243.944	1.09941
325	28s ribosomal protein s12, mitochondrial precursor (mpr-s12) (mt- rps12). [swissprot;acc:o15235]
326	60s ribosomal protein l5. [swissprot;acc:p46777]	265.924	241.899	1.09932

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.