MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Network Comparison Type	Rank	Gene	Value Type	Hugo	description	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 186 to 235 of 515 in total

Network Comparison Type  : Subtracted
Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1
red  : 0
network_comparison  : 0
green  : 0

Rank	Hugo	description
2941	TAF4B	transcription initiation factor tfiid 105 kda subunit (tafii-105) (tafii105) (fragment). [swissprot;acc:q92750]
2942	SS18	ssxt protein (synovial sarcoma, translocated to x chromosome) (syt protein). [swissprot;acc:q15532]
2943	PRPSAP2	phosphoribosyl pyrophosphate synthetase-associated protein 2 (prpp synthetase-associated protein 2) (41 kda phosphoribosypyrophosphate synthetase-associated protein) (pap41). [swissprot;acc:o60256]
2944	TIGD7	tigger transposable element derived 7; jerky (mouse) homolog-like. [refseq;acc:nm_033208]
2945	TPM1	tropomyosin 1 alpha chain (alpha-tropomyosin). [swissprot;acc:p09493]
2946	GTF2A2	transcription initiation factor iia gamma chain (tfiia p12 subunit) (tfiia-12) (tfiias) (tfiia-gamma). [swissprot;acc:p52657]
2947	SERF2	small edrk-rich factor 2. [refseq;acc:nm_005770]
2948	TCF12	transcription factor 12 (transcription factor htf-4) (e-box-binding protein) (dna-binding protein htf4). [swissprot;acc:q99081]
2949	MFAP1	microfibrillar-associated protein 1. [swissprot;acc:p55081]
2950	TEGT	bax inhibitor-1 (bi-1) (testis enhanced gene transcript). [swissprot;acc:p55061]
2951	ITGB7	integrin beta-7 precursor. [swissprot;acc:p26010]
2952	ACVRL1	serine/threonine-protein kinase receptor r3 precursor (ec 2.7.1.37) (skr3) (activin receptor-like kinase 1) (alk-1) (tgf-b superfamily receptor type i) (tsr-i). [swissprot;acc:p37023]
2953	GLIPR1	glioma pathogenesis-related protein (glipr) (rtvp-1 protein). [swissprot;acc:p48060]
2954	NDUFA9	nadh-ubiquinone oxidoreductase 39 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-39kd) (ci-39kd). [swissprot;acc:q16795]
2955	FBN2	fibrillin 2 precursor. [swissprot;acc:p35556]
2956	SEC24B	protein transport protein sec24b (sec24-related protein b). [swissprot;acc:o95487]
2957	ENPEP	glutamyl aminopeptidase (ec 3.4.11.7) (eap) (aminopeptidase a) (apa) (differentiation antigen gp160). [swissprot;acc:q07075]
2958	CNOT6L	ccr4-not transcription complex, subunit 6-like. [refseq;acc:nm_144571]
2959	no value	60s ribosomal protein l37a. [swissprot;acc:p12751]
2960	AOX1	aldehyde oxidase (ec 1.2.3.1). [swissprot;acc:q06278]
2961	RAB1A	ras-related protein rab-1a (ypt1-related protein). [swissprot;acc:p11476]
2962	DYNC2LI1	dynein 2 light intermediate chain. [refseq;acc:nm_016008]
2963	RABGGTB	geranylgeranyl transferase type ii beta subunit (ec 2.5.1.-) (rab geranylgeranyltransferase beta subunit) (rab geranyl- geranyltransferase beta subunit) (rab gg transferase beta) (rab ggtase beta). [swissprot;acc:p53611]
2964	SEMA6D	semaphorin 6d isoform 3 precursor. [refseq;acc:nm_153617]
2965	SLCO5A1	solute carrier family 21 member 15 (organic anion transporter polypeptide-related protein 4) (oatp-rp4) (oatprp4). [swissprot;acc:q9h2y9]
2966	PI15	protease inhibitor 15 preproprotein; 25 kda trypsin inhibitor. [refseq;acc:nm_015886]
2967	TAF8	taube nuss. [refseq;acc:nm_138572]
2968	RNF144B	ba528a10.3.2 (novel protein similar to kiaa0161, isoform 2) (fragment). [sptrembl;acc:q9bx39]
2969	TFAP2A	transcription factor ap-2 alpha (ap2-alpha) (activating enhancer- binding protein 2 alpha) (ap-2 transcription factor) (activator protein-2) (ap-2). [swissprot;acc:p05549]
2970	NOV	nov protein homolog precursor (novh) (nephroblastoma overexpressed gene protein homolog). [swissprot;acc:p48745]
2971	XPA	dna-repair protein complementing xp-a cells (xeroderma pigmentosum group a complementing protein). [swissprot;acc:p23025]
2972	NR5A1	steroidogenic factor 1 (stf-1) (sf-1) (steroid hormone receptor ad4bp) (fushi tarazu factor homolog 1). [swissprot;acc:q13285]
2973	ALDOB	fructose-bisphosphate aldolase b (ec 4.1.2.13) (liver-type aldolase). [swissprot;acc:p05062]
2974	CDK9	cell division protein kinase 9 (ec 2.7.1.-) (serine/threonine-protein kinase pitalre) (c-2k). [swissprot;acc:p50750]
2975	KCTD3	potassium channel tetramerisation domain containing 3; ny-ren-45 antigen. [refseq;acc:nm_016121]
2976	CAB39	mo25 protein (cgi-66). [swissprot;acc:q9y376]
2977	CYP27A1	cytochrome p450 27, mitochondrial precursor (ec 1.14.-.-) (cytochrome p-450c27/25) (sterol 26-hydroxylase) (sterol 27-hydroxylase) (vitamin d(3) 25-hydroxylase) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase). [swissprot;acc:q02318]
2978	ITGA7	integrin alpha-7 precursor. [swissprot;acc:q13683]
2979	UGT2B28	udp-glucuronosyltransferase 2b28 precursor, microsomal (ec 2.4.1.17). [swissprot;acc:q9by64]
2980	TAOK3	ste20-like kinase; ste2-like kinase. [refseq;acc:nm_016281]
2981	DZIP1	zinc finger daz interacting protein 1. [refseq;acc:nm_014934]
2982	no value	serine/threonine protein kinase mask; ste20-like kinase mst4. [refseq;acc:nm_016542]
2983	CCNH	cyclin h (mo15-associated protein) (p37) (p34). [swissprot;acc:p51946]
2984	MED10	similar to cg5057 gene product. [sptrembl;acc:q9btt4]
2985	MYH11	myosin heavy chain, smooth muscle isoform (smmhc). [swissprot;acc:p35749]
2986	CSNK1G2	casein kinase i, gamma 2 isoform (ec 2.7.1.-) (cki-gamma 2). [swissprot;acc:p78368]
2987	SPG20	spartin; trans-activated by hepatitis c virus core protein 1. [refseq;acc:nm_015087]
2988	MYH10	myosin heavy chain, nonmuscle type b (cellular myosin heavy chain, type b) (nonmuscle myosin heavy chain-b) (nmmhc-b). [swissprot;acc:p35580]
2989	no value	high mobility group protein 1 (hmg-1). [swissprot;acc:p09429]
2990	CDK8	cell division protein kinase 8 (ec 2.7.1.-) (protein kinase k35). [swissprot;acc:p49336]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.