Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Rank Gene Hugo description Value Type Network Comparison Type Interaction Map Filtered green red network_comparison
Results: HTML CSV LaTeX Showing element 551 to 600 of 12912 in total
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1
Rank
Hugo
description
Value Type
green
red
network_comparison
138 PPP2CA serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323] Ranked 234.204 194.372 1.20493
UBAC1 putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172] Squared 322755 468498 1.45156
139 APBA1 amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410] Ranked 225.68 271.752 1.20415
CCNB2 g2/mitotic-specific cyclin b2. [swissprot;acc:o95067] Squared 56211.1 81592.1 1.45153
KCNIP4 potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183] Measured 2099.49 2759.61 1.31442
ZC3H14 nuclear protein ukp68. [refseq;acc:nm_024824] Rooted 66.2416 54.9787 1.20486
140 CDK2 cell division protein kinase 2 (ec 2.7.1.-) (p33 protein kinase). [swissprot;acc:p24941] Squared 56190.6 81527.6 1.45091
FLNB filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457] Rooted 66.7332 55.6161 1.19989
KCNIP2 kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193] Measured 2100.27 2760.28 1.31425
RRAGA ras-related gtp binding a; ras-related gtp-binding protein. [refseq;acc:nm_006570] Ranked 49 59 1.20408
141 CCNB1 g2/mitotic-specific cyclin b1. [swissprot;acc:p14635] Squared 56188.5 81520.8 1.45084
REV1 rev1-like; rev1 protein; rev1 (yeast homolog)- like. [refseq;acc:nm_016316] Rooted 66.7332 55.6161 1.19989
RRAGC ras-related gtp binding c; rag c protein. [refseq;acc:nm_022157] Ranked 49 59 1.20408
SNRPD2 small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330] Measured 5782.08 4405.4 1.3125
142 CDC2 cell division control protein 2 homolog (ec 2.7.1.-) (p34 protein kinase) (cyclin-dependent kinase 1) (cdk1). [swissprot;acc:p06493] Squared 56175.2 81478.9 1.45044
PITRM1 metalloprotease 1; metalloprotease 1 (pitrilysin family). [refseq;acc:nm_014889] Measured 7090.37 9276.47 1.30832
PRMT1 protein arginine n-methyltransferase 1 (ec 2.1.1.-) (interferon receptor 1-bound protein 4). [swissprot;acc:q99873] Rooted 66.7332 55.6161 1.19989
RRAGB ras-related gtp binding b short isoform; gtp-binding protein ragb. [refseq;acc:nm_006064] Ranked 49 59 1.20408
143 ALG1 beta-1,4 mannosyltransferase. [refseq;acc:nm_019109] Measured 7089.65 9275.1 1.30826
ANLN anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685] Ranked 49 59 1.20408
PPP1R13B protein phosphatase 1, regulatory (inhibitor) subunit 13b; apoptosis-stimulating protein of p53, 1. [refseq;acc:nm_015316] Squared 86848.2 124319 1.43145
PRMT8 protein arginine n-methyltransferase 4 (ec 2.1.1.-). [swissprot;acc:q9nr22] Rooted 66.7332 55.6161 1.19989
144 KCNIP1 kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592] Ranked 319.651 265.686 1.20312
SNRP70 u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [swissprot;acc:p08621] Rooted 66.7332 55.6161 1.19989
TP53BP2 tumor suppressor p53-binding protein 2 (p53-binding protein 2) (53bp2) (bcl2-binding protein) (bbp). [swissprot;acc:q13625] Squared 86277.9 123324 1.42938
UNC84A sad1/unc-84 protein-like 1. [swissprot;acc:o94901] Measured 4362.61 3349.9 1.30231
145 no value filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333] Rooted 66.7332 55.6161 1.19989
nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333] Squared 442993 310840 1.42515
ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395] Measured 12889.1 16771.5 1.30122
KCNIP4 potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183] Ranked 319.546 265.639 1.20293
146 KCNIP2 kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193] 319.531 265.632 1.20291
PRPF40B huntingtin interacting protein c. [refseq;acc:nm_012272] Rooted 66.0298 55.0737 1.19894
RRAGA ras-related gtp binding a; ras-related gtp-binding protein. [refseq;acc:nm_006570] Squared 146848 103496 1.41888
STAMBPL1 associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799] Measured 8508.5 11068 1.30082
147 no value nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333] Ranked 42.3003 50.7983 1.2009
CHMP2A putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453] Measured 8508.5 11068 1.30082
FOXP4 forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457] Rooted 50.4237 42.0574 1.19893
RRAGC ras-related gtp binding c; rag c protein. [refseq;acc:nm_022157] Squared 146848 103496 1.41888
148 FOXP1 forkhead box protein p1 (hspc215). [swissprot;acc:q9h334] Rooted 50.424 42.0577 1.19892
RRAGB ras-related gtp binding b short isoform; gtp-binding protein ragb. [refseq;acc:nm_006064] Squared 146848 103496 1.41888
STAMBP associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463] Measured 8508.5 11068 1.30082
UNC84A sad1/unc-84 protein-like 1. [swissprot;acc:o94901] Ranked 247.559 296.677 1.19841
149 no value atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915] 170 142 1.19718
ANLN anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685] Squared 146848 103496 1.41888
FOXP3 forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1] Rooted 50.4323 42.0684 1.19882
VPS24 neuroendocrine differentiation factor; comparative gene identification transcript 149. [refseq;acc:nm_016079] Measured 8508.5 11068 1.30082
150 CHMP4A protein hspc134 (protein cda04). [swissprot;acc:q9by43]
CLP1 pre-mrna cleavage complex ii protein clp1. [swissprot;acc:q92989] Squared 85473.4 121200 1.41799
MYO5B myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0] Ranked 46 55 1.19565
PPP2CA serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323] Rooted 53.0856 63.5827 1.19774

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/