MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Value Type	Gene	description	Rank	Interaction Map	Network Comparison Type	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 982 to 1031 of 3228 in total

Value Type  : Ranked
Interaction Map  : High confidence
Network Comparison Type  : Divided
Filtered  : 1

description	Rank	red	green	network_comparison
eukaryotic translation initiation factor 5a (eif-5a) (eif-4d) (rev- binding factor). [swissprot;acc:p10159]	2102	208.727	210.263	1.00736
eukaryotic translation initiation factor 6 (eif-6) (b4 integrin interactor) (cab) (p27(bbp)) (b(2)gcn homolog). [swissprot;acc:p56537]	545	248.866	233.287	1.06678
evolutionarily conserved g-patch domain containing. [refseq;acc:nm_018025]	573	227.86	213.945	1.06504
evolutionarily conserved signaling intermediate in toll pathway; ecsit. [refseq;acc:nm_016581]	2092	211.992	210.369	1.00772
exocyst complex component exo70. [swissprot;acc:q9upt5]	2781	0.00001	0.00001	1
exocyst complex component sec10 (hsec10). [swissprot;acc:o00471]	721	214.765	203.8	1.0538
exocyst complex component sec15a. [swissprot;acc:q8tag9]	750	222.138	211.503	1.05028
exocyst complex component sec15b. [swissprot;acc:q9y2d4]	749	221.968	211.326	1.05036
exocyst complex component sec3 (bm-012). [swissprot;acc:q9nv70]	2487	218.093	218.72	1.00287
exocyst complex component sec5. [swissprot;acc:q96kp1]	986	116.771	120.707	1.03371
exocyst complex component sec6. [swissprot;acc:o60645]	981	207.186	200.398	1.03387
exocyst complex component sec8. [swissprot;acc:q96a65]	869	217.762	209.449	1.03969
exonuclease 1 isoform b; rad2 nuclease family member, homolog of s. cerevisiae exonuclease 1. [refseq;acc:nm_006027]	1344	216.772	221.594	1.02224
exosome complex exonuclease rrp4 (ec 3.1.13.-) (ribosomal rna processing protein 4). [swissprot;acc:q13868]	523	215.237	230.07	1.06891
exosome complex exonuclease rrp40 (ec 3.1.13.-) (ribosomal rna processing protein 40) (p10) (cgi-102). [swissprot;acc:q9nqt5]	524
exosome complex exonuclease rrp41 (ec 3.1.13.-) (ribosomal rna processing protein 41) (p12a). [swissprot;acc:q9npd3]	521
exosome complex exonuclease rrp46 (ec 3.1.13.-) (ribosomal rna processing protein 46) (p12b) (chronic myelogenous leukemia tumor antigen 28). [swissprot;acc:q9nqt4]	525
exportin 1; exportin-1 (required for chromosome region maintenance); exportin 1 (crm1, yeast, homolog); crm1, yeast, homolog. [refseq;acc:nm_003400]	1497	224.476	220.363	1.01866
eyes absent homolog 1. [swissprot;acc:q99502]	1396	218.463	213.872	1.02147
eyes absent homolog 2. [swissprot;acc:o00167]	1399	218.417	213.848	1.02137
eyes absent homolog 3. [swissprot;acc:q99504]	1376	218.537	213.91	1.02163
eyes absent homolog 4. [swissprot;acc:o95677]	1398	218.449	213.864	1.02144
ezrin-binding partner pace-1 isoform 1. [refseq;acc:nm_020423]	3228	0.00001	0.00001	1
f-actin capping protein alpha-1 subunit (capz alpha-1). [swissprot;acc:p52907]	1824	214.722	212.281	1.0115
f-actin capping protein alpha-2 subunit (capz alpha-2). [swissprot;acc:p47755]	1831	214.746	212.328	1.01139
f-actin capping protein alpha-3 subunit (capz alpha-3) (germ cell- specific protein 3). [swissprot;acc:q96kx2]	2032	215.322	213.46	1.00872
f-actin capping protein beta subunit (capz beta). [swissprot;acc:p47756]	2033
f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	209	285.684	252.234	1.13261
fad synthetase. [refseq;acc:nm_025207]	270	241.373	267.352	1.10763
far upstream element-binding protein; far upstream element binding protein; fuse-binding protein. [refseq;acc:nm_003902]	2656	217.179	216.943	1.00109
farnesyl pyrophosphate synthetase (fpp synthetase) (fps) (farnesyl diphosphate synthetase) [includes: dimethylallyltransferase (ec 2.5.1.1); geranyltranstransferase (ec 2.5.1.10)]. [swissprot;acc:p14324]	2462	235.812	235.088	1.00308
fas apoptotic inhibitory molecule. [refseq;acc:nm_018147]	2068	220.8	222.61	1.0082
fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402]	1442	225.039	229.573	1.02015
fatty acid desaturase 2; linoleoyl-coa desaturase (delta-6-desaturase)-like 2; delta-6 fatty acid desaturase. [refseq;acc:nm_004265]	1441
fatty acid desaturase 3; linoleoyl-coa desaturase (delta-6-desaturase)-like 3; delta-6 fatty acid desaturase. [refseq;acc:nm_021727]	1439
fatty acid hydroxylase domain containing 1. [refseq;acc:nm_024306]	1536	228.419	232.376	1.01732
fatty acid-binding protein, adipocyte (afabp) (adipocyte lipid-binding protein) (albp) (a-fabp). [swissprot;acc:p15090]	2214	221.509	220.108	1.00637
fatty acid-binding protein, brain (b-fabp) (brain lipid-binding protein) (blbp) (mammary derived growth inhibitor related). [swissprot;acc:o15540]	2216
fatty acid-binding protein, epidermal (e-fabp) (psoriasis-associated fatty acid-binding protein homolog) (pa-fabp). [swissprot;acc:q01469]	2215
fatty acid-binding protein, heart (h-fabp) (muscle fatty acid-binding protein) (m-fabp) (mammary-derived growth inhibitor) (mdgi). [swissprot;acc:p05413]	2223
fatty aldehyde dehydrogenase (ec 1.2.1.3) (aldehyde dehydrogenase, microsomal) (aldh class 3). [swissprot;acc:p51648]	3181	0.00001	0.00001	1
fatty-acid amide hydrolase (ec 3.1.-.-) (oleamide hydrolase) (anandamide amidohydrolase). [swissprot;acc:o00519]	1218	211.959	217.258	1.025
fem-1 homolog b; fem-1-like death receptor binding protein; fem-1 (c.elegans) homolog b. [refseq;acc:nm_015322]	469	248.152	267.226	1.07686
ferritin heavy chain (ferritin h subunit). [swissprot;acc:p02794]	697	220.444	209.113	1.05419
ferritin heavy polypeptide-like 17. [swissprot;acc:q9bxu8]	712	220.431	209.123	1.05407
ferritin light chain (ferritin l subunit). [swissprot;acc:p02792]	709	220.438	209.118	1.05413
ferrochelatase, mitochondrial precursor (ec 4.99.1.1) (protoheme ferro-lyase) (heme synthetase). [swissprot;acc:p22830]	3185	0.00001	0.00001	1
fetal brain protein 239 (239fb). [swissprot;acc:q15777]	2339	229.258	230.294	1.00452
fibrillarin (34 kda nucleolar scleroderma antigen). [swissprot;acc:p22087]	748	245.246	233.483	1.05038
fibrillin 1 precursor. [swissprot;acc:p35555]	2844	0.00001	0.00001	1

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.