Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Value Type Gene description Rank Interaction Map Network Comparison Type Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 932 to 981 of 3228 in total
Value Type  : Ranked
Interaction Map  : High confidence
Network Comparison Type  : Divided
Filtered  : 1
description
Rank
red
green
network_comparison
endosome-associated fyve-domain protein. [refseq;acc:nm_014733] 3200 0.00001 0.00001 1
endothelial-derived gene 1. [refseq;acc:nm_025205] 1918 202.211 200.18 1.01015
enhancer of filamentation 1 (hef1) (crk-associated substrate-related protein) (cas-l) (casl) (pp105) (neural precursor cell expressed developmentally down-regulated 9). [swissprot;acc:q14511] 286 224.633 203.251 1.1052
enhancer of rudimentary homolog. [swissprot;acc:q14259] 2676 214.893 215.108 1.001
enhancer of zeste homolog 1 (enx-2). [swissprot;acc:q92800] 3090 0.00001 0.00001 1
enhancer of zeste homolog 2 (enx-1). [swissprot;acc:q15910] 3098
enigma protein; lim domain protein. [refseq;acc:nm_005451] 1929 219.753 217.574 1.01001
enoyl-coa hydratase, mitochondrial precursor (ec 4.2.1.17) (short chain enoyl-coa hydratase) (sceh) (enoyl-coa hydratase 1). [swissprot;acc:p30084] 1403 184.656 180.823 1.0212
enteropeptidase precursor (ec 3.4.21.9) (enterokinase). [swissprot;acc:p98073] 577 224.606 210.944 1.06477
enthoprotin; epsin 4; clathrin interacting protein localized in the trans-golgi region. [refseq;acc:nm_014666] 1612 221.426 224.902 1.0157
epidermal growth factor receptor kinase substrate eps8. [swissprot;acc:q12929] 1153 221.93 216.146 1.02676
epidermal growth factor receptor pathway substrate 8-like protein 1 isoform c; epidermal growth factor receptor pathway substrate 8-related protein 1; eps8-related protein 1. [refseq;acc:nm_139204] 1152 221.939 216.143 1.02682
epidermal growth factor receptor pathway substrate 8-like protein 2; eps8-related protein 2; epidermal growth factor receptor pathway substrate 8-related protein 2. [refseq;acc:nm_022772] 1158 221.877 216.167 1.02641
epidermal growth factor receptor precursor (ec 2.7.1.112) (receptor protein-tyrosine kinase erbb-1). [swissprot;acc:p00533] 2005 225.019 222.971 1.00919
epididymal secretory protein e1 precursor (niemann-pick disease type c2 protein) (epi-1) (he1) (epididymal secretory protein 14.6) (esp14.6). [swissprot;acc:q15668] 1339 205.204 200.71 1.02239
epithelial-cadherin precursor (e-cadherin) (uvomorulin) (cadherin-1) (cam 120/80). [swissprot;acc:p12830] 320 241.892 265.96 1.0995
epoxide hydrolase 1 (ec 3.3.2.3) (microsomal epoxide hydrolase) (epoxide hydratase). [swissprot;acc:p07099] 2446 182.272 181.683 1.00324
epsin 1; eh domain-binding mitotic phosphoprotein. [refseq;acc:nm_013333] 2430 217.873 218.644 1.00354
epsin 2 isoform b; eps15 binding protein. [refseq;acc:nm_014964] 2550 217.587 217.988 1.00184
epsin 3. [refseq;acc:nm_017957] 2297 218.153 219.284 1.00518
ergic-53 protein precursor (er-golgi intermediate compartment 53 kda protein) (lectin, mannose-binding 1) (gp58) (intracellular mannose specific lectin mr60). [swissprot;acc:p49257] 3177 0.00001 0.00001 1
ero1-like. [refseq;acc:nm_014584] 911 217.168 209.207 1.03805
erythroid differentiation and denucleation factor 1. [swissprot;acc:o60584] 1566 221.128 224.767 1.01646
erythroid differentiation-related factor 1. [refseq;acc:nm_015608] 3095 0.00001 0.00001 1
espin. [refseq;acc:nm_031475] 1257 219.354 224.7 1.02437
esterase d (ec 3.1.1.1). [swissprot;acc:p10768] 2429 192.871 193.555 1.00355
estradiol 17 beta-dehydrogenase 1 (ec 1.1.1.62) (17-beta-hsd 1) (placental 17-beta-hydroxysteroid dehydrogenase) (20 alpha- hydroxysteroid dehydrogenase) (20-alpha-hsd) (e2dh). [swissprot;acc:p14061] 1050 211.449 217.998 1.03097
estradiol 17 beta-dehydrogenase 4 (ec 1.1.1.62) (17-beta-hsd 4) (17-beta-hydroxysteroid dehydrogenase 4). [swissprot;acc:p51659] 1768 185.276 187.534 1.01219
estrogen-related receptor gamma (estrogen receptor related protein 3) (err gamma-2). [swissprot;acc:o75454] 1042 186.799 181.127 1.03132
ethanolamine kinase (ec 2.7.1.82) (eki). [swissprot;acc:q9hbu6] 2378 212.724 213.574 1.004
ethanolamine kinase-like protein eki2 (flj10761). [swissprot;acc:q9nvf9] 2377
ethanolamine-phosphate cytidylyltransferase (ec 2.7.7.14) (phosphorylethanolamine transferase) (ctp:phosphoethanolamine cytidylyltransferase). [swissprot;acc:q99447] 1758 233.45 230.595 1.01238
eukaryotic initiation factor 4a-i (eif-4a-i) (eif4a-i). [swissprot;acc:p04765] 2868 0.00001 0.00001 1
eukaryotic initiation factor 4a-ii (eif-4a-ii) (eif4a-ii). [swissprot;acc:q14240] 2888
eukaryotic peptide chain release factor subunit 1 (erf1) (eukaryotic release factor 1) (tb3-1) (c11 protein). [swissprot;acc:p46055] 772 210.946 221.225 1.04873
eukaryotic translation initiation factor 2 subunit 1 (eukaryotic translation initiation factor 2 alpha subunit) (eif-2-alpha) (eif- 2alpha) (eif-2a). [swissprot;acc:p05198] 1341 226.433 231.491 1.02234
eukaryotic translation initiation factor 2 subunit 2 (eukaryotic translation initiation factor 2 beta subunit) (eif-2-beta). [swissprot;acc:p20042] 1839 221.525 224.001 1.01118
eukaryotic translation initiation factor 2 subunit 3 (eukaryotic translation initiation factor 2 gamma subunit) (eif-2-gamma). [swissprot;acc:p41091] 1865 221.639 224.046 1.01086
eukaryotic translation initiation factor 3 subunit 10 (eif-3 theta) (eif3 p167) (eif3 p180) (eif3 p185) (eif3a). [swissprot;acc:q14152] 904 246.354 237.223 1.03849
eukaryotic translation initiation factor 3 subunit 11 (eif-3 p25) (eif3k) (muscle specific gene m9 protein) (ptd001) (hspc029) (arg134). [swissprot;acc:q9ubq5] 1565 221.128 224.767 1.01646
eukaryotic translation initiation factor 3 subunit 2 (eif-3 beta) (eif3 p36) (eif3i) (tgf-beta receptor interacting protein 1) (trip-1). [swissprot;acc:q13347] 746 250.465 238.38 1.0507
eukaryotic translation initiation factor 3 subunit 4 (eif-3 delta) (eif3 p44) (eif-3 rna-binding subunit) (eif3 p42) (eif3g). [swissprot;acc:o75821] 903 246.354 237.223 1.03849
eukaryotic translation initiation factor 3 subunit 6 interacting protein (hspc021/hspc025). [swissprot;acc:q9y262] 1571 221.128 224.767 1.01646
eukaryotic translation initiation factor 3 subunit 7 (eif-3 zeta) (eif3 p66) (eif3d). [swissprot;acc:o15371] 1931 219.753 217.574 1.01001
eukaryotic translation initiation factor 3 subunit 8 (eif3 p110) (eif3c). [swissprot;acc:q99613] 1405 245.532 240.483 1.021
eukaryotic translation initiation factor 3 subunit 9 (eif-3 eta) (eif3 p116) (eif3 p110) (eif3b). [swissprot;acc:p55884] 822 243.067 232.805 1.04408
eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637] 252 237.292 212.457 1.11689
eukaryotic translation initiation factor 4 gamma, 3. [refseq;acc:nm_003760] 246 237.312 212.363 1.11748
eukaryotic translation initiation factor 4e (eif-4e) (eif4e) (mrna cap-binding protein) (eif-4f 25 kda subunit). [swissprot;acc:p06730] 649 233.725 220.751 1.05877
eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010] 268 271.016 244.167 1.10996

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/