Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene Interaction Map description Value Type Network Comparison Type green Filtered red network_comparison
Results: HTML CSV LaTeX Showing element 51 to 100 of 8289 in total
Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1
Rank
Interaction Map
description
green
red
network_comparison
26 High confidence pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999] 44 58 1.31818
Low confidence cytochrome p450 27, mitochondrial precursor (ec 1.14.-.-) (cytochrome p-450c27/25) (sterol 26-hydroxylase) (sterol 27-hydroxylase) (vitamin d(3) 25-hydroxylase) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase). [swissprot;acc:q02318] 238.454 286.347 1.20085
27 High confidence mitochondrial solute carrier protein. [refseq;acc:nm_145305] 44 58 1.31818
Low confidence cytochrome p450 24a1, mitochondrial precursor (ec 1.14.-.-) (p450- cc24) (vitamin d(3) 24-hydroxylase) (1,25-dihydroxyvitamin d(3) 24- hydroxylase) (24-ohase). [swissprot;acc:q07973] 237.743 284.798 1.19792
28 High confidence cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847] 153.671 201.949 1.31416
Low confidence atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915] 170 142 1.19718
29 High confidence uncharacterized hematopoietic stem/progenitor cells protein mds026. [sptrembl;acc:q9nz48] 243.678 187.458 1.29991
Low confidence cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847] 170.557 203.115 1.19089
30 High confidence serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, alpha isoform (pp2a, subunit b, b-alpha isoform) (pp2a, subunit b, b55-alpha isoform) (pp2a, subunit b, pr55-alpha isoform) (pp2a, subunit b, r2-alpha isoform). [swissprot;acc:q00007] 243.678 187.457 1.29991
Low confidence bcl2-related ovarian killer. [refseq;acc:nm_032515] 223.235 265.638 1.18995
31 High confidence serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, beta isoform (pp2a, subunit b, b-beta isoform) (pp2a, subunit b, b55- beta isoform) (pp2a, subunit b, pr55-beta isoform) (pp2a, subunit b, r2-beta isoform). [swissprot;acc:q00005] 243.677 187.458 1.2999
Low confidence deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233] 48.8186 57.395 1.17568
32 High confidence serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, gamma isoform (pp2a, subunit b, b-gamma isoform) (pp2a, subunit b, b55-gamma isoform) (pp2a, subunit b, pr55-gamma isoform) (pp2a, subunit b, r2-gamma isoform) (imypno1). [swissprot;acc:q9y2t4] 243.673 187.462 1.29985
Low confidence protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690] 232.49 273.188 1.17505
33 High confidence serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, beta isoform (pp2a, subunit a, pr65-beta isoform) (pp2a, subunit a, r1-beta isoform). [swissprot;acc:p30154] 242.742 188.688 1.28647
Low confidence dual specificity mitogen-activated protein kinase kinase 4 (ec 2.7.1.-) (map kinase kinase 4) (jnk activating kinase 1) (c-jun n- terminal kinase kinase 1) (jnkk) (sapk/erk kinase 1) (sek1). [swissprot;acc:p45985] 246.125 210.241 1.17068
34 High confidence serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, alpha isoform (pp2a, subunit a, pr65-alpha isoform) (pp2a, subunit a, r1-alpha isoform) (medium tumor antigen-associated 61 kda protein). [swissprot;acc:p30153] 242.453 189.07 1.28235
Low confidence putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172] 133.876 155.56 1.16197
35 High confidence nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952] 204.309 260.532 1.27519
Low confidence tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106] 258.59 297.273 1.14959
36 High confidence ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511] 204.309 260.532 1.27519
Low confidence tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616] 258.33 296.837 1.14906
37 High confidence protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256] 253 322 1.27273
Low confidence chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0] 217.843 250.244 1.14874
38 High confidence microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083] 253 322 1.27273
Low confidence glucosamine-6-phosphate isomerase. [refseq;acc:nm_138335] 282.937 247.202 1.14456
39 High confidence protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726] 253 322 1.27273
Low confidence glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [swissprot;acc:p46926] 282.937 247.202 1.14456
40 High confidence ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485] 253 322 1.27273
Low confidence son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583] 223.538 255.382 1.14245
41 High confidence protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949] 253 322 1.27273
Low confidence ba127l20.1 (novel glutathione-s-transferase). [sptrembl;acc:q9h4y5] 200.55 228.147 1.13761
42 High confidence proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100] 160.957 204.641 1.2714
Low confidence glutathione transferase omega 1 (ec 2.5.1.18) (gsto 1-1). [swissprot;acc:p78417] 200.532 227.371 1.13384
43 High confidence jun dimerization protein. [refseq;acc:nm_130469] 160.957 204.641 1.2714
Low confidence regulator of g-protein signaling 12 (rgs12). [swissprot;acc:o14924] 219.841 247.768 1.12703
44 High confidence fos-related antigen 2. [swissprot;acc:p15408] 161.046 204.641 1.2707
Low confidence protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256] 217.217 242.742 1.11751
45 High confidence protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539] 161.051 204.641 1.27066
Low confidence microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083] 217.217 242.742 1.11751
46 High confidence fos-related antigen 1 (fra-1). [swissprot;acc:p15407] 161.068 204.642 1.27053
Low confidence protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726] 217.217 242.742 1.11751
47 High confidence gbp protein isoform a. [refseq;acc:nm_017870] 256.492 325.586 1.26938
Low confidence ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485] 217.217 242.742 1.11751
48 High confidence gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278] 83.0461 65.4586 1.26868
Low confidence protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949] 217.217 242.742 1.11751
49 High confidence beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121] 105 133 1.26667
Low confidence t-box transcription factor tbx19 (t-box protein 19). [swissprot;acc:o60806] 202.569 225.438 1.11289
50 High confidence beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407] 105 133 1.26667
Low confidence junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2] 260.98 234.802 1.11149

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/