MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Value Type	Gene	Rank	green	Interaction Map	description	Network Comparison Type	Filtered	red	network_comparison

Results: HTML CSV LaTeX

Showing element 908 to 957 of 3228 in total

Value Type  : Ranked
Interaction Map  : High confidence
Network Comparison Type  : Divided
Filtered  : 1

Rank	green	description	red	network_comparison
908	215.653	tax interaction protein 1. [refseq;acc:nm_014604]	223.906	1.03827
909	136.846	septin 1 (larp) (serologically defined breast cancer antigen ny-br- 24). [swissprot;acc:q8wyj6]	142.077	1.03823
910	209.207	uba/ubx 33.3 kda protein. [swissprot;acc:q04323]	217.168	1.03805
911		ero1-like. [refseq;acc:nm_014584]
912	234.96	wd-repeat protein 3. [swissprot;acc:q9unx4]	243.896	1.03803
913	218.878	prip-interacting protein pipmt; prip-interacting protein with methyltransferase domain. [refseq;acc:nm_024831]	210.863	1.03801
914		pdz/coiled-coil domain binding partner for the rho-family gtpase tc10; fused in glioblastoma; golgi associated pdz and coiled-coil motif containing protein; cftr-associated ligand. [refseq;acc:nm_020399]
915	140.692	trna (5-methylaminomethyl-2-thiouridylate)-methyltransferase (ec 2.1.1.61). [swissprot;acc:o75648]	146.036	1.03798
916	241.288	hydroxyacid oxidase 2 (ec 1.1.3.15) (haox2) ((s)-2-hydroxy-acid oxidase, peroxisomal) (long chain alpha-hydroxy acid oxidase) (long- chain l-2-hydroxy acid oxidase). [swissprot;acc:q9nyq3]	232.512	1.03774
917	230.991	parafibromin. [refseq;acc:nm_024529]	239.704	1.03772
918	205.292	ponsin; sh3-domain protein 5 (ponsin). [refseq;acc:nm_015385]	212.952	1.03731
919	228.698	midasin (midas-containing protein). [swissprot;acc:q9nu22]	237.218	1.03725
920	245.547	deformed epidermal autoregulatory factor 1 homolog (nuclear deaf-1 related transcriptional regulator) (nudr) (suppressin) (zinc finger mynd domain containing protein 5). [swissprot;acc:o75398]	236.741	1.0372
921		rio kinase 1 isoform 1; ad034 protein. [refseq;acc:nm_031480]
922		map/microtubule affinity-regulating kinase 1. [refseq;acc:nm_018650]
923		map/microtubule affinity-regulating kinase 2 isoform b; elkl motif kinase 1; elkl motif kinase. [refseq;acc:nm_004954]
924		meiotic recombination protein spo11. [swissprot;acc:q9y5k1]
925	207.942	pef protein with a long n-terminal hydrophobic domain (peflin). [refseq;acc:nm_012392]	215.665	1.03714
926	210.139	imp2 inner mitochondrial membrane protease-like; inner mitochondrial membrane peptidase 2 like. [refseq;acc:nm_032549]	217.942	1.03713
927		microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378]
928	218.017	peptide chain release factor 1, mitochondrial precursor (mrf-1). [swissprot;acc:o75570]	225.976	1.03651
929	218.015	mannose-p-dolichol utilization defect 1 protein (suppressor of lec15 and lec35 glycosylation mutation homolog) (sl15). [swissprot;acc:o75352]	225.955	1.03642
930	239.778	pyruvate kinase, m1 isozyme (ec 2.7.1.40) (pyruvate kinase muscle isozyme) (cytosolic thyroid hormone-binding protein) (cthbp) (thbp1). [swissprot;acc:p14618]	231.357	1.0364
931	164.917	ba305p22.3 (breast carcinoma amplified sequence 4). [sptrembl;acc:q8ndy6]	159.13	1.03637
932	218.013	mitochondrial translational release factor 1-like. [refseq;acc:nm_019041]	225.939	1.03636
933	164.951	basic helix-loop-helix domain containing, class b, 5; trinucleotide repeat containing 20. [refseq;acc:nm_152414]	159.165	1.03635
934	233.544	nucleolar rna-associated protein alpha isoform. [refseq;acc:nm_022917]	242.024	1.03631
935	224.372	sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538]	232.473	1.03611
936		casein kinase ii beta chain (ck ii) (phosvitin) (g5a). [swissprot;acc:p13862]
937	212.618	splicing factor 3a subunit 3 (spliceosome associated protein 61) (sap 61) (sf3a60). [swissprot;acc:q12874]	220.246	1.03588
938		splicing factor 3 subunit 1 (spliceosome associated protein 114) (sap 114) (sf3a120). [swissprot;acc:q15459]
939	224.27	breast cancer type 1 susceptibility protein. [swissprot;acc:p38398]	216.501
940	205.088	calcium-dependent protease, small subunit (calpain regulatory subunit) (calcium-activated neutral proteinase) (canp). [swissprot;acc:p04632]	212.442	1.03586
941	205.083	swi/snf-related, matrix-associated, actin-dependent regulator of chromatin subfamily f member 1 (swi-snf complex protein p270) (b120). [swissprot;acc:o14497]	212.437
942	205.088	grancalcin. [swissprot;acc:p28676]	212.442
943	205.087	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]
944	205.083	programmed cell death protein 6 (probable calcium-binding protein alg- 2). [swissprot;acc:o75340]	212.437
945	205.085	brg1-binding protein eld/osa1; eld (eyelid)/osa protein. [refseq;acc:nm_020732]	212.44
946	219.902	histone h4. [swissprot;acc:p02304]	227.765	1.03576
947	205.191	arg/abl-interacting protein 2 isoform 2; arg binding protein 2. [refseq;acc:nm_021069]	212.51	1.03567
948	209.824	target of myb protein 1. [swissprot;acc:o60784]	217.254	1.03541
949	209.826	huntingtin-associated protein-interacting protein (duo protein). [swissprot;acc:o60229]	217.253	1.0354
950	261.821	dna-repair protein complementing xp-g cells (xeroderma pigmentosum group g complementing protein) (dna excision repair protein ercc-5). [swissprot;acc:p28715]	252.873	1.03539
951	209.827	triple functional domain protein (ptprf interacting protein). [swissprot;acc:o75962]	217.253
952	209.83	target of myb1-like 2; target of myb1 (chicken) homolog-like 2. [refseq;acc:nm_144678]	217.252	1.03537
953	205.466	polymyositis/scleroderma autoantigen 2 (autoantigen pm/scl 2) (polymyositis/scleroderma autoantigen 100 kda) (pm/scl-100) (p100 polymyositis-scleroderma overlap syndrome associated autoantigen). [swissprot;acc:q01780]	198.494	1.03512
954	276.773	maleylacetoacetate isomerase (ec 5.2.1.2) (maai) (glutathione s- transferase zeta 1) (ec 2.5.1.18) (gstz1-1). [swissprot;acc:o43708]	267.447	1.03487
955	239.205	mitochondrial 60s ribosomal protein l27 (l27mt) (hspc250). [swissprot;acc:q9p0m9]	231.163	1.03479
956	204.732	vinexin (sh3-containing adaptor molecule-1) (scam-1). [swissprot;acc:o60504]	211.812	1.03458
957	134.399	a-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (a-raf-1) (proto-oncogene pks). [swissprot;acc:p10398]	129.913	1.03453

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.