MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	Value Type	Rank	description	Filtered	Interaction Map	Network Comparison Type	green	network_comparison	red

Results: HTML CSV LaTeX

Showing element 551 to 600 of 14920 in total

Value Type  : Measured
Interaction Map  : High confidence
Network Comparison Type  : Divided

Rank	description	Filtered	green	network_comparison	red
276	apoptosis inhibitor fksg2. [swissprot;acc:q9hau6]	0	12125.1	1.12092	10817.1
	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	1	2579.49	1.20953	3119.98
277	disks large-associated protein 2 (dap-2) (sap90/psd-95-associated protein 2) (sapap2) (psd-95/sap90 binding protein 2) (fragment). [swissprot;acc:q9p1a6]	0	975.647	1.12024	870.93
	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]	1	2579.49	1.20953	3119.98
278	rna-binding protein nova-1 (neuro-oncological ventral antigen 1) (onconeural ventral antigen-1) (paraneoplastic ri antigen) (ventral neuron-specific protein 1). [swissprot;acc:p51513]	0	1932	1.11922	2162.33
	transcription factor lbx1. [swissprot;acc:p52954]	1	2579.49	1.20953	3119.98
279	cell adhesion molecule with homology to l1cam precursor; neural cell adhesion molecule; cell adhesion molecule l1-like; l1 cell adhesion molecule 2. [refseq;acc:nm_006614]	0	610.424	1.11819	545.902
	mosaic protein lgn. [swissprot;acc:p81274]	1	2579.49	1.20953	3119.98
280	neural cell adhesion molecule l1 precursor (n-cam l1) (cd171 antigen). [swissprot;acc:p32004]	0	610.424	1.11819	545.902
	regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]	1	2579.49	1.20953	3119.98
281	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]
	transcription initiation factor tfiid 31 kda subunit (tafii-31) (tafii-32) (tafii32). [swissprot;acc:q16594]	0	610.424	1.11819	545.902
282	pepsin a precursor (ec 3.4.23.1). [swissprot;acc:p00790]		199.751	1.11621	178.955
	rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736]	1	2579.49	1.20953	3119.98
283	lon protease homolog, mitochondrial precursor (ec 3.4.21.-) (lon protease-like protein) (lonp) (lonhs). [swissprot;acc:p36776]	0	753.849	1.11601	841.301
	polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195]	1	6314.35	1.20935	5221.28
284	60s ribosomal protein l23 (l17). [swissprot;acc:p23131]	0	1956.36	1.11547	1753.85
	paxillin. [swissprot;acc:p49023]	1	6314.35	1.20935	5221.28
285	dj408b20.3 (novel protein similar to 60s acidic ribosomal protein p2 (rplp2)). [sptrembl;acc:q9h5a9]	0	3010.22	1.11547	2698.62
	poly(a) polymerase alpha (ec 2.7.7.19) (pap) (polynucleotide adenylyltransferase alpha) (fragment). [swissprot;acc:p51003]	1	19296.4	1.20885	23326.5
286	clathrin heavy chain 2 (clh-22). [swissprot;acc:p53675]	0	6127.24	1.11465	5497.01
	exocyst complex component sec5. [swissprot;acc:q96kp1]	1	19288.8	1.20878	23316
287	5-aminolevulinic acid synthase, nonspecific, mitochondrial precursor (ec 2.3.1.37) (delta-aminolevulinate synthase) (delta-ala synthetase) (alas-h). [swissprot;acc:p13196]	0	808.929	1.11385	726.245
	poly(a) polymerase gamma (ec 2.7.7.19) (pap gamma) (polynucleotide adenylyltransferase gamma) (srp rna 3' adenylating enzyme). [swissprot;acc:q9bwt3]	1	19279.5	1.2087	23303.1
288	cleavage and polyadenylation specificity factor, 73 kda subunit (cpsf 73 kda subunit). [swissprot;acc:q9ukf6]		19380.3	1.20857	23422.4
	likely ortholog of mouse shc sh2-domain binding protein 1. [refseq;acc:nm_024745]	0	1161.64	1.11371	1293.73
289	tubby protein homolog. [swissprot;acc:p50607]		4228.27	1.11341	3797.57
	u6 snrna-associated sm-like protein lsm6 (sm protein f). [swissprot;acc:q9y4y8]	1	5646.19	1.20571	4682.88
290	dna topoisomerase ii, beta isozyme (ec 5.99.1.3). [swissprot;acc:q02880]	0	1525.56	1.11288	1370.82
	tuftelin-interacting protein 11 (hspc006). [swissprot;acc:q9ubb9]	1	6014.08	1.20487	4991.48
291	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]		36927.5	1.20481	44490.5
	similar to ribosomal protein, large, p0. [sptrembl;acc:q96fq9]	0	2179.77	1.11151	1961.09
292	ba271b5.1 (similar to ribosomal protein s7). [sptrembl;acc:q9h1s9]		12473	1.11138	11223
	nucleotide-binding protein 1 (nbp 1). [swissprot;acc:p53384]	1	5588.75	1.20419	4641.09
293	block 23. [sptrembl;acc:q8nhw5]	0	2159.55	1.11127	1943.32
	nucleotide binding protein 2 (nbp 2). [swissprot;acc:q9y5y2]	1	5588.75	1.20419	4641.09
294	cleavage stimulation factor subunit 3; cleavage stimulation factor, 3' pre-rna, subunit 3, 77kd. [refseq;acc:nm_001326]		18702.6	1.20387	22515.5
	mesoderm induction early response 1. [refseq;acc:nm_020948]	0	1723.5	1.11082	1914.5
295	adaptor-related protein complex 1, mu 2 subunit (mu-adaptin 2) (adaptor protein complex ap-1 mu-2 subunit) (golgi adaptor ha1/ap1 adaptin mu-2 subunit) (clathrin assembly protein assembly protein complex 1 medium chain 2) (ap-mu chain family member mu1b). [swissprot;acc:q9y6q5]		384.843	1.10902	426.8
	ral guanine nucleotide dissociation stimulator-like 1 (ralgds-like 1). [swissprot;acc:q9nzl6]	1	11017.8	1.20368	13261.9
296	pnas-18. [sptrembl;acc:q9bzu3]	0	2035.28	1.10847	2256.05
	splicing factor 3a subunit 2 (spliceosome associated protein 62) (sap 62) (sf3a66). [swissprot;acc:q15428]	1	5909.18	1.20306	4911.81
297	40s ribosomal protein s29. [swissprot;acc:p30054]	0	1895.38	1.10737	1711.6
	krueppel-like factor 5 (intestinal-enriched krueppel-like factor) (colon krueppel-like factor) (transcription factor bteb2) (basic transcription element binding protein 2) (bte-binding protein 2) (gc box binding protein 2). [swissprot;acc:q13887]	1	5909.18	1.20306	4911.81
298	u6 snrna-associated sm-like protein lsm2 (small nuclear ribonuclear protein d homolog) (g7b) (snrnp core sm-like protein sm-x5). [swissprot;acc:q9y333]		5572.85	1.20262	4633.92
	williams-beuren syndrome chromosome region 14 protein (ws basic-helix- loop-helix leucine zipper protein) (ws-bhlh) (mlx interactor). [swissprot;acc:q9np71]	0	848	1.10731	939
299	ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36]	1	5907.12	1.20203	4914.27
	cyclin-dependent kinases regulatory subunit 1 (cks-1) (sid1334) (pnas-16 / pnas-143). [swissprot;acc:p33551]	0	2015.09	1.10717	2231.05
300	sterol regulatory element binding protein-2 (srebp-2) (sterol regulatory element-binding transcription factor 2). [swissprot;acc:q12772]		1205.1	1.10712	1334.19
	u2 small nuclear ribonucleoprotein a' (u2 snrnp-a'). [swissprot;acc:p09661]	1	5907.12	1.20203	4914.27

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.