Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Gene Rank description Network Comparison Type Value Type Interaction Map Filtered red network_comparison green
Results: HTML CSV LaTeX Showing element 451 to 500 of 9634 in total
Network Comparison Type  : Divided
Value Type  : Measured
Rank
description
Interaction Map
Filtered
red
network_comparison
green
113 sh2-b homolog; likely ortholog of mouse sh2 domain-containing putative adapter sh2-b; sh2-b gamma signaling protein; sh2-b alpha signaling protein. [refseq;acc:nm_015503] Low confidence 0 107 1.37179 78
sh3 domain-binding glutamic acid-rich-like protein 2 (fovea-associated sh3 domain binding protein). [swissprot;acc:q9ujc5] High confidence 160 1.42539 112.25
114 calponin h2, smooth muscle (neutral calponin). [swissprot;acc:q99439] Low confidence 768.061 1.36592 1049.11
daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959] High confidence 671.769 1.4204 472.945
huntingtin interacting protein c. [refseq;acc:nm_012272] 1 4300.47 1.35048 5807.72
melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364] Low confidence 11285.3 1.0937 10318.5
115 28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5] High confidence 21185 1.34491 28492
g protein-coupled receptor kinase grk5 (ec 2.7.1.-) (g-protein-coupled receptor kinase 5). [swissprot;acc:p34947] Low confidence 0 556 1.3561 410
melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356] 1 11285.3 1.0937 10318.5
zinc finger protein-like 1; zinc-finger protein in men1 region. [refseq;acc:nm_006782] High confidence 0 385 1.41039 543
116 alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7] 668 1.40632 475
g protein-coupled receptor kinase grk6 (ec 2.7.1.-) (g-protein-coupled receptor kinase 6). [swissprot;acc:p43250] Low confidence 556 1.3561 410
hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932] 1 11285.3 1.0937 10318.5
pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04] High confidence 21185 1.34491 28492
117 helicase/primase complex protein. [refseq;acc:nm_138336] Low confidence 0 284 1.35238 210
melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360] 1 11285.3 1.0937 10318.5
pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23] High confidence 21185 1.34491 28492
ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395] 0 170.5 1.39754 122
118 methyltransferase like 2. [refseq;acc:nm_018396] 31 1.3871 43
necdin. [swissprot;acc:q99608] Low confidence 1 11285.3 1.0937 10318.5
pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999] High confidence 21185 1.34491 28492
transcription elongation factor a protein 1 (transcription elongation factor s-ii protein 1) (transcription elongation factor tfiis.o). [swissprot;acc:p23193] Low confidence 0 83.6667 1.3506 113
119 estrogen-related receptor gamma (estrogen receptor related protein 3) (err gamma-2). [swissprot;acc:o75454] High confidence 633.85 1.37734 460.2
melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3] Low confidence 1 11285.3 1.0937 10318.5
mitochondrial 28s ribosomal protein s22 (s22mt) (mrp-s22) (gk002). [swissprot;acc:p82650] 0 81.504 1.33918 60.8613
mitochondrial solute carrier protein. [refseq;acc:nm_145305] High confidence 1 21185 1.34491 28492
120 high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339] 5136.78 1.34247 6895.98
melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2] Low confidence 11285.3 1.0937 10318.5
proactivator polypeptide precursor [contains: saposin a (protein a); saposin b (sphingolipid activator protein 1) (sap-1) (cerebroside sulfate activator) (csact) (dispersin) (sulfatide/gm1 activator); saposin c (co-beta-glucosidase) (a1 activator) (glucosylceramidase activator) (sphingolipid activator protein 2) (sap-2); saposin d (protein c) (component c)]. [swissprot;acc:p07602] 0 180.7 1.3378 241.74
signal-induced proliferation-associated 1-like 1. [refseq;acc:nm_015556] High confidence 494.417 1.37479 359.631
121 4-aminobutyrate aminotransferase, mitochondrial precursor (ec 2.6.1.19) (gamma-amino-n-butyrate transaminase) (gaba transaminase) (gaba aminotransferase) (gaba-at) (gaba-t). [swissprot;acc:p80404] 19.6667 1.3721 14.3333
melanoma antigen, family b, 6. [refseq;acc:nm_173523] Low confidence 1 11285.3 1.0937 10318.5
sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626] 0 2961.07 1.3351 3953.32
transcription factor jun-b. [swissprot;acc:p17275] High confidence 1 5579.18 1.3422 7488.4
122 high-mobility group 20a. [refseq;acc:nm_018200] 5140.14 1.34112 6893.53
melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358] Low confidence 11285.3 1.0937 10318.5
sh2-b homolog; likely ortholog of mouse sh2 domain-containing putative adapter sh2-b; sh2-b gamma signaling protein; sh2-b alpha signaling protein. [refseq;acc:nm_015503] High confidence 0 107 1.37179 78
ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395] Low confidence 2376 1.3339 3169.35
123 cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936] High confidence 1 24260.3 1.33503 18172.1
maspin precursor (protease inhibitor 5). [swissprot;acc:p36952] Low confidence 0 42 1.33333 56
melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362] 1 11285.3 1.0937 10318.5
ret finger protein 2 (leukemia associated protein 5) (b-cell chronic lymphocytic leukemia tumor suppressor leu5) (putative tumor suppressor rfp2) (tripartite motif protein 13). [swissprot;acc:o60858] High confidence 0 2285.62 1.35944 1681.3
124 melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361] Low confidence 1 11285.3 1.0937 10318.5
microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8] High confidence 24255.7 1.33501 18168.9
regulator of chromosome condensation (cell cycle regulatory protein). [swissprot;acc:p18754] 0 3248.95 1.35386 2399.76
serpin b11. [swissprot;acc:q96p15] Low confidence 42 1.33333 56
125 cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [swissprot;acc:p50452]
melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732] 1 11285.3 1.0937 10318.5
microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492] High confidence 24255.7 1.33501 18168.9
probable calcium-transporting atpase kiaa0703 (ec 3.6.3.8). [swissprot;acc:o75185] 0 1095.42 1.34876 812.166

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/