Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Rank Gene Hugo description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 825 to 874 of 6456 in total
Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1
Rank
Hugo
description
Network Comparison Type
red
green
network_comparison
413 POLR1C dna-directed rna polymerase i 40 kda polypeptide (ec 2.7.7.6) (rpa40) (rpa39). [swissprot;acc:o15160] Divided 240.913 261.45 1.08525
TFIP11 tuftelin-interacting protein 11 (hspc006). [swissprot;acc:q9ubb9] Subtracted 223.202 205.9 17.302
414 KATNA1 katanin p60 subunit a 1. [refseq;acc:nm_007044] Divided 232.431 252.238 1.08522
MAX max protein. [swissprot;acc:p25912] Subtracted 227.828 210.561 17.267
415 KATNB1 katanin p80 subunit b 1; katanin (80 kda); katanin p80 (wd40-containing) subunit b 1. [refseq;acc:nm_005886] Divided 232.382 252.166 1.08514
TAF7 transcription initiation factor tfiid 55 kda subunit (tafii-55) (tafii55). [swissprot;acc:q15545] Subtracted 200.586 183.423 17.163
416 POLR1B dna-directed rna polymerase i 135 kda polypeptide (ec 2.7.7.6) (rna polymerase i subunit 2) (rpa135). [swissprot;acc:q9h9y6] Divided 240.6 261.041 1.08496
TAF7L tata box binding protein-associated factor, rna polymerase ii, q; taf7-like rna polymerase ii, tata box binding protein (tbp)-associated factor, 50 kd; tbp-associated factor, rna polymerase ii, q. [refseq;acc:nm_024885] Subtracted 200.791 183.66 17.131
417 SETMAR set domain and mariner transposase fusion gene. [refseq;acc:nm_006515] Divided 233.539 253.197 1.08417
SRP9 signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458] Subtracted 235.94 218.837 17.103
418 ARD1A n-terminal acetyltransferase complex ard1 subunit homolog (ec 2.3.1.-). [swissprot;acc:p41227] 233.723 216.674 17.049
CLEC4M cd209 antigen-like; putative type ii membrane protein. [refseq;acc:nm_014257] Divided 233.539 253.197 1.08417
419 FCER2 low affinity immunoglobulin epsilon fc receptor (lymphocyte ige receptor) (fc-epsilon-rii) (cd23) (blast-2) (immunoglobulin e-binding factor). [swissprot;acc:p06734]
SRP9 signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458] Subtracted 235.922 218.925 16.997
420 CD209 cd209 antigen; dendritic cell-specific icam3-grabbing nonintegrin. [refseq;acc:nm_021155] Divided 233.539 253.197 1.08417
CYC1 cytochrome c1, heme protein, mitochondrial precursor (cytochrome c-1). [swissprot;acc:p08574] Subtracted 238.704 255.68 16.976
421 ARHGAP26 oligophrenin-1 like protein (gtpase regulator associated with focal adhesion kinase). [swissprot;acc:q9una1]
TFIP11 tuftelin-interacting protein 11 (hspc006). [swissprot;acc:q9ubb9] Divided 223.202 205.9 1.08403
422 RAB37 ras-related protein rab-37. [swissprot;acc:q96ax2] 240.287 260.193 1.08284
RGN senescence marker protein-30 (smp-30) (regucalcin) (rc). [swissprot;acc:q15493] Subtracted 238.704 255.68 16.976
423 OPHN1 oligophrenin 1. [swissprot;acc:o60890]
RAB26 ras-related protein rab-26. [swissprot;acc:q9ulw5] Divided 240.287 260.193 1.08284
424 GTPBP4 nucleolar gtp-binding protein 1 (chronic renal failure gene protein) (gtp-binding protein ngb). [swissprot;acc:q9bze4] Subtracted 251.83 234.951 16.879
POLR2C dna-directed rna polymerase ii 33 kda polypeptide (ec 2.7.7.6) (rpb3) (rna polymerase ii subunit 3) (rpb33) (rpb31). [swissprot;acc:p19387] Divided 240.287 260.193 1.08284
425 ENDOG endonuclease g, mitochondrial precursor (ec 3.1.30.-) (endo g). [swissprot;acc:q14249] Subtracted 212.547 229.411 16.864
MAX max protein. [swissprot;acc:p25912] Divided 227.828 210.561 1.082
426 AIFM1 programmed cell death protein 8, mitochondrial precursor (ec 1.-.-.-) (apoptosis-inducing factor). [swissprot;acc:o95831] Subtracted 212.547 229.411 16.864
DCTN5 dynactin 4. [refseq;acc:nm_032486] Divided 233.142 252.253 1.08197
427 POLR2E dna-directed rna polymerase ii 23 kda polypeptide (ec 2.7.7.6) (rpb25) (xap4) (rpb5) (rpabc1). [swissprot;acc:p19388] 239.977 259.525 1.08146
TBX6 t-box transcription factor tbx6 (t-box protein 6). [swissprot;acc:o95947] Subtracted 212.547 229.411 16.864
428 DDX54 atp-dependent rna helicase mgc2835; atp-dependent rna helicase; apoptosis related protein apr-5; dead box helicase 97 kda. [refseq;acc:nm_024072] Divided 253.852 234.808 1.0811
LSM5 u6 snrna-associated sm-like protein lsm5. [swissprot;acc:q9y4y9] Subtracted 227.748 210.888 16.86
429 EBNA1BP2 probable rrna processing protein ebp2 (ebna1 binding protein 2) (nucleolar protein p40). [swissprot;acc:q99848] 251.344 234.514 16.83
POLR3G polymerase (rna) iii (dna directed) (32kd). [refseq;acc:nm_006467] Divided 239.709 259.038 1.08064
430 LSM5 u6 snrna-associated sm-like protein lsm5. [swissprot;acc:q9y4y9] 227.748 210.888 1.07995
PPAN-P2RY11 suppressor of swi4 1 homolog (ssf-1) (peter pan homolog). [swissprot;acc:q9nq55] Subtracted 250.938 234.134 16.804
431 BAG3 bag-family molecular chaperone regulator-3 (bcl-2 binding athanogene- 3) (bag-3) (bcl-2-binding protein bis) (docking protein cair-1). [swissprot;acc:o95817] 233.529 216.737 16.792
TRUB1 trub pseudouridine (psi) synthase homolog 1. [refseq;acc:nm_139169] Divided 236.245 255.113 1.07987
432 ENDOG endonuclease g, mitochondrial precursor (ec 3.1.30.-) (endo g). [swissprot;acc:q14249] 212.547 229.411 1.07934
MCTS1 mct-1 protein. [refseq;acc:nm_014060] Subtracted 226.313 243.03 16.717
433 AIFM1 programmed cell death protein 8, mitochondrial precursor (ec 1.-.-.-) (apoptosis-inducing factor). [swissprot;acc:o95831] Divided 212.547 229.411 1.07934
MRPL22 mitochondrial ribosomal protein l22. [refseq;acc:nm_014180] Subtracted 226.313 243.03 16.717
434 NOC3L ad24 protein. [refseq;acc:nm_022451] 251.334 234.672 16.662
TBX6 t-box transcription factor tbx6 (t-box protein 6). [swissprot;acc:o95947] Divided 212.547 229.411 1.07934
435 POLI polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195] 221.522 205.286 1.07909
WDR12 wd-repeat protein 12 (ytm1 homolog). [swissprot;acc:q9gzl7] Subtracted 251.299 234.729 16.57
436 PXN paxillin. [swissprot;acc:p49023] Divided 221.522 205.286 1.07909
TPI1 triosephosphate isomerase (ec 5.3.1.1) (tim). [swissprot;acc:p00938] Subtracted 231.496 248.048 16.552
437 TRIP10 cdc42-interacting protein 4 (thyroid receptor interacting protein 10) (trip-10). [swissprot;acc:q15642] Divided 209.921 226.459 1.07878
Subtracted 16.538

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/