Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 823 to 872 of 8289 in total
Value Type  : Measured
Network Comparison Type  : Divided
Filtered  : 1
Rank
description
Interaction Map
red
green
network_comparison
412 clip-associating protein 1; drosophila 'multiple asters' (mast)-like homolog 1. [refseq;acc:nm_015282] Low confidence 6973.35 7340.39 1.05263
mki67 (fha domain) interacting nucleolar phosphoprotein; nucleolar phosphoprotein nopp34; nucleolar protein interacting with the fha domain of pki-67. [refseq;acc:nm_032390] High confidence 3594.31 4169.95 1.16015
413 max-interacting transcriptional repressor mad4 (max-associated protein 4) (max dimerization protein 4). [swissprot;acc:q14582] Low confidence 6974.82 7341.65 1.05259
vav proto-oncogene. [swissprot;acc:p15498] High confidence 6644.99 7707.8 1.15994
414 autophagy protein 5-like (apg5-like) (apoptosis-specific protein). [swissprot;acc:q9h1y0] 6744.05 5815.13 1.15974
max dimerization protein 3; likely ortholog of mouse max dimerization protein 3. [refseq;acc:nm_031300] Low confidence 6975.39 7342.13 1.05258
415 hn1 like. [refseq;acc:nm_144570] 8657.07 9111.9 1.05254
vav-3 protein. [swissprot;acc:q9ukw4] High confidence 6647.43 7706.18 1.15927
416 n-terminal acetyltransferase complex ard1 subunit homolog (ec 2.3.1.-). [swissprot;acc:p41227] 4509.54 5223.95 1.15842
transgelin (smooth muscle protein 22-alpha) (sm22-alpha) (ws3-10) (22 kda actin-binding protein). [swissprot;acc:q01995] Low confidence 6972.28 7338.33 1.0525
417 amyloid beta precursor protein-binding protein 1; amyloid protein-binding protein 1. [refseq;acc:nm_003905] 7902.1 8316.41 1.05243
bag-family molecular chaperone regulator-3 (bcl-2 binding athanogene- 3) (bag-3) (bcl-2-binding protein bis) (docking protein cair-1). [swissprot;acc:o95817] High confidence 4522.71 5233.14 1.15708
418 breast carcinoma amplified sequence 2; spliceosome associated protein, amplified in breast cancer. [refseq;acc:nm_005872] 5493.1 6350.19 1.15603
iroquois-class homeodomain protein irx-4 (iroquois homeobox protein 4). [swissprot;acc:p78413] Low confidence 8958.02 9427.3 1.05239
419 argininosuccinate lyase (ec 4.3.2.1) (arginosuccinase) (asal). [swissprot;acc:p04424] 8768.68 9227.9 1.05237
cdc5-like; cdc5 (cell division cycle 5, s. pombe, homolog)-like; cell division cycle 5, s. pombe, homolog-like; cdc5-related protein. [refseq;acc:nm_001253] High confidence 5493.1 6350.19 1.15603
420 hypoxanthine-guanine phosphoribosyltransferase (ec 2.4.2.8) (hgprt) (hgprtase). [swissprot;acc:p00492] 10235.2 11830.8 1.15589
latrophilin 3; latrophilin homolog 3 (cow); lectomedin 3. [refseq;acc:nm_015236] Low confidence 8768.68 9227.9 1.05237
421 latrophilin 2; lectomedin-1; latrophilin homolog 2 (cow). [refseq;acc:nm_012302]
vav-2 protein. [swissprot;acc:p52735] High confidence 6660.02 7697.78 1.15582
422 latrophilin 1; lectomedin-2; latrophilin homolog 1 (cow). [refseq;acc:nm_014921] Low confidence 8768.68 9227.9 1.05237
nuclear rna export factor 5 (tap-like protein 1) (tapl-1). [swissprot;acc:q9h1b4] High confidence 5206.9 6010.04 1.15425
423 nuclear rna export factor 3 (tap-like protein 3) (tapl-3). [swissprot;acc:q9h4d5] 5207.03 6010.1 1.15423
protein tyrosine phosphatase, non-receptor type 14 (ec 3.1.3.48) (protein-tyrosine phosphatase pez). [swissprot;acc:q15678] Low confidence 8902.76 9368.39 1.0523
424 nuclear rna export factor 1 (tip associating protein) (tip-associated protein) (mrna export factor tap). [swissprot;acc:q9ubu9] High confidence 5207.78 6010.45 1.15413
protein tyrosine phosphatase, non-receptor type 21 (ec 3.1.3.48) (protein-tyrosine phosphatase d1). [swissprot;acc:q16825] Low confidence 8902.76 9368.39 1.0523
425 ras-related protein rab-7. [swissprot;acc:p51149] 8055.75 8476.72 1.05226
saccharomyces cerevisiae nip7p homolog. [refseq;acc:nm_016101] High confidence 3729.02 4301.58 1.15354
426 pef protein with a long n-terminal hydrophobic domain (peflin). [refseq;acc:nm_012392] 5942.49 6853.15 1.15325
proton/amino acid transporter 4. [refseq;acc:nm_152313] Low confidence 8913.45 9379.02 1.05223
427 neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401] 8174.72 8601.49 1.05221
trna (5-methylaminomethyl-2-thiouridylate)-methyltransferase (ec 2.1.1.61). [swissprot;acc:o75648] High confidence 11736.6 13531.9 1.15297
428 neuronal protein np25. [swissprot;acc:q9ui15] Low confidence 6962.59 7326.01 1.0522
nucleolar gtp-binding protein 1 (chronic renal failure gene protein) (gtp-binding protein ngb). [swissprot;acc:q9bze4] High confidence 3721.19 4288.17 1.15237
429 f-box only protein 9. [swissprot;acc:q9uk97] Low confidence 9028.53 9499.15 1.05213
vinexin (sh3-containing adaptor molecule-1) (scam-1). [swissprot;acc:o60504] High confidence 6272.91 7226.06 1.15195
430 sortilin precursor (glycoprotein 95) (gp95) (neurotensin receptor 3) (nt3) (100 kda nt receptor). [swissprot;acc:q99523] Low confidence 8342.99 8777.22 1.05205
transcription factor dp-2 (e2f dimerization partner 2). [swissprot;acc:q14188] High confidence 3804.09 4379.37 1.15123
431 dead (asp-glu-ala-asp) box polypeptide 31 isoform 1; dead/dexh helicase ddx31. [refseq;acc:nm_022779] 3849.94 4431.36 1.15102
high-affinity cgmp-specific 3',5'-cyclic phosphodiesterase 9a (ec 3.1.4.17). [swissprot;acc:o76083] Low confidence 8906.4 9368.48 1.05188
432 mitochondrial processing peptidase beta subunit, mitochondrial precursor (ec 3.4.24.64) (beta-mpp) (p-52). [swissprot;acc:o75439] High confidence 5244.71 6036.27 1.15093
solute carrier family 36 member 1; proton / amino acid symporter; lysosomal amino acid transporter 1. [refseq;acc:nm_078483] Low confidence 8906.4 9368.48 1.05188
433 mitochondrial processing peptidase alpha subunit, mitochondrial precursor (ec 3.4.24.64) (alpha-mpp) (p-55) (ha1523). [swissprot;acc:q10713] High confidence 5244.88 6036.38 1.15091
transgelin 2 (sm22-alpha homolog). [swissprot;acc:p37802] Low confidence 6983.46 7345.76 1.05188
434 small nuclear ribonucleoprotein e (snrnp-e) (sm protein e) (sm-e) (sme). [swissprot;acc:p08578] 7870.63 8276.86 1.05161
ubiquinol-cytochrome c reductase complex core protein i, mitochondrial precursor (ec 1.10.2.2). [swissprot;acc:p31930] High confidence 5246.38 6037.37 1.15077
435 cytochrome p450 51a1 (ec 1.14.13.70) (cypli) (p450li) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (ldm) (p450-14dm). [swissprot;acc:q16850] Low confidence 7740.82 8139.75 1.05154
proline synthetase co-transcribed bacterial homolog protein. [swissprot;acc:o94903] High confidence 5233.86 6022.6 1.1507
436 arg/abl-interacting protein 2 isoform 2; arg binding protein 2. [refseq;acc:nm_021069] 6230.94 7168.2 1.15042
brain protein 16. [refseq;acc:nm_016458] Low confidence 8822.87 9277.39 1.05152

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/