Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene Hugo description Value Type Network Comparison Type Interaction Map Filtered red network_comparison green
Results: HTML CSV LaTeX Showing element 782 to 831 of 25824 in total
Interaction Map  : High confidence
Filtered  : 1
Rank
Hugo
description
Value Type
Network Comparison Type
red
network_comparison
green
98 MAGEA4 melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365] Ranked Divided 88.2482 1.24949 110.265
PSEN2 presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810] Measured 2353.63 1.3705 3225.65
SEPT10 septin 10 isoform 1. [refseq;acc:nm_144710] Squared Subtracted 89578.7 36304.3 125883
99 no value jun dimerization protein. [refseq;acc:nm_130469] Ranked 204.641 43.684 160.957
melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355] Divided 88.2482 1.24949 110.265
BRP44 brain protein 44. [swissprot;acc:o95563] Squared Subtracted 89182.8 36046.2 125229
GPSM2 mosaic protein lgn. [swissprot;acc:p81274] Rooted Divided 47.6504 1.29028 36.9304
SEPT7 septin 7 (cdc10 protein homolog). [swissprot;acc:q16181] Measured Subtracted 15999.1 3008 19007.1
SKP1A s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991] Divided 2353.63 1.3705 3225.65
TOB2 tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106] Rooted Subtracted 19.9625 15.8355 35.798
WDR33 wd-repeat protein wdc146. [swissprot;acc:q9c0j8] Squared Divided 226186 1.55382 145568
100 CPSF1 cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]
FBXW7 f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315] Measured 2353.63 1.3705 3225.65
FOSL2 fos-related antigen 2. [swissprot;acc:p15408] Ranked Subtracted 204.641 43.595 161.046
MAGEA10 melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363] Divided 88.2482 1.24949 110.265
RGS17 regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6] Rooted 47.6504 1.29028 36.9304
SEPT6 septin 6. [swissprot;acc:q14141] Measured Subtracted 15959.9 2997.2 18957.1
SEPT7 septin 7 (cdc10 protein homolog). [swissprot;acc:q16181] Squared 89182.8 36046.2 125229
TOB1 tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616] Rooted 19.9625 15.8355 35.798
101 CPSF2 cleavage and polyadenylation specificity factor, 100 kda subunit (cpsf 100 kda subunit) (fragment). [swissprot;acc:q9p2i0] Squared Divided 222655 1.5507 143584
CUL2 cullin homolog 2 (cul-2). [swissprot;acc:q13617] Measured 2353.63 1.3705 3225.65
DAB2IP dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552] Rooted Subtracted 19.9625 15.8355 35.798
FOSB protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539] Ranked 204.641 43.59 161.051
GNAO1 guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471] Rooted Divided 47.6504 1.29028 36.9304
MAGEB4 melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366] Ranked 88.2482 1.24949 110.265
SEPT4 septin 4 (peanut-like protein 2) (brain protein h5) (cell division control-related protein 2) (hcdcrel-2) (bradeion beta) (ce5b3 beta) (cerebral protein-7) (hucep-7). [swissprot;acc:o43236] Measured Subtracted 14924.4 2730.8 17655.2
SEPT6 septin 6. [swissprot;acc:q14141] Squared 88953.6 35900.4 124854
102 CLP1 pre-mrna cleavage complex ii protein clp1. [swissprot;acc:q92989] 121200 35726.6 85473.4
CPEB4 cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627] Rooted 19.9625 15.8355 35.798
FIP1L1 fip1-like 1; rearranged in hypereosinophilia. [refseq;acc:nm_030917] Squared Divided 214143 1.54798 138337
FOSL1 fos-related antigen 1 (fra-1). [swissprot;acc:p15407] Ranked Subtracted 204.642 43.574 161.068
MAGED2 melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1] Divided 88.2482 1.24949 110.265
PSEN1 presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768] Measured 2353.63 1.3705 3225.65
RAP1GAP rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736] Rooted 47.6504 1.29028 36.9304
STAMBPL1 associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799] Measured Subtracted 11068 2559.5 8508.5
103 no value mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476] Squared Divided 407289 1.54656 263351
CHMP2A putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453] Measured Subtracted 11068 2559.5 8508.5
CPEB3 cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912] Rooted 19.9625 15.8355 35.798
CUL1 cullin homolog 1 (cul-1). [swissprot;acc:q13616] Measured Divided 2353.63 1.3705 3225.65
FOS proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100] Rooted 60.8365 1.27758 77.7233
JUNB transcription factor jun-b. [swissprot;acc:p17275] Ranked Subtracted 201.144 42.276 158.868
SYMPK symplekin. [swissprot;acc:q92797] Squared 124118 35449.2 88668.8
TRO trophinin. [swissprot;acc:q12816] Ranked Divided 88.2482 1.24949 110.265
104 no value jun dimerization protein. [refseq;acc:nm_130469] Rooted 60.8365 1.27758 77.7233
CSTF2T likely ortholog of mouse variant polyadenylation protein cstf-64. [refseq;acc:nm_015235] Squared Subtracted 121579 34319.7 87259.3
HOMER2 homer, neuronal immediate early gene, 2; homer homolog 3 (drosophila). [refseq;acc:nm_004839] Ranked Divided 252.371 1.24926 202.016
MSI2 musashi 2 isoform a. [refseq;acc:nm_138962] Measured 4241.57 1.36996 5810.79
PSCD1 cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438] Squared 407289 1.54656 263351
RASAL2 ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2] Rooted Subtracted 19.9625 15.8355 35.798
STAMBP associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463] Measured 11068 2559.5 8508.5

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/