Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 7591 to 7640 of 12912 in total
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1
Rank
description
Value Type
red
green
network_comparison
1898 transcription factor relb (i-rel). [swissprot;acc:q01201] Squared 46338.5 42353.5 1.09409
voltage-gated potassium channel beta-3 subunit (k+ channel beta-3 subunit) (kv-beta-3). [swissprot;acc:o43448] Rooted 63.4354 65.2789 1.02906
1899 lim/homeobox protein lhx3. [swissprot;acc:q9ubr4] Ranked 199.884 197.837 1.01035
nf-kappab inhibitor alpha (major histocompatibility complex enhancer- binding protein mad3) (i-kappa-b-alpha) (ikappabalpha) (ikb-alpha). [swissprot;acc:p25963] Squared 46338.5 42353.5 1.09409
ruvb-like 2 (ec 3.6.1.-) (48-kda tata box-binding protein-interacting protein) (48-kda tbp-interacting protein) (tip49b) (repressing pontin 52) (reptin 52) (51 kda erythrocyte cytosolic protein) (ecp-51) (tip60-associated protein 54-beta) (tap54-beta) (cgi-46). [swissprot;acc:q9y230] Measured 5786.36 6149.1 1.06269
voltage-gated potassium channel beta-1 subunit (k+ channel beta-1 subunit) (kv-beta-1). [swissprot;acc:q14722] Rooted 63.4353 65.2789 1.02906
1900 coproporphyrinogen iii oxidase, mitochondrial precursor (ec 1.3.3.3) (coproporphyrinogenase) (coprogen oxidase) (cox). [swissprot;acc:p36551] Squared 46338.5 42353.5 1.09409
seven in absentia homolog 2. [refseq;acc:nm_005067] Measured 5399.47 5737.79 1.06266
similar to putative transmembrane protein; homolog of yeast golgi membrane protein yif1p (yip1p-interacting factor). [refseq;acc:nm_033557] Rooted 63.4353 65.2789 1.02906
solute carrier family 27 (fatty acid transporter), member 4; fatty acid transport protein 4. [refseq;acc:nm_005094] Ranked 191.401 193.38 1.01034
1901 aflatoxin b1 aldehyde reductase 2 (ec 1.-.-.-) (afb1-ar 2). [swissprot;acc:o95154] Rooted 63.4353 65.2789 1.02906
delta(14)-sterol reductase (ec 1.3.1.70) (c-14 sterol reductase) (sterol c14-reductase) (delta14-sr) (transmembrane 7 superfamily member 2) (another new gene 1) (putative sterol reductase sr-1). [swissprot;acc:o76062] Ranked 191.411 193.39 1.01034
inorganic pyrophosphatase (ec 3.6.1.1) (pyrophosphate phospho- hydrolase) (ppase). [swissprot;acc:q15181] Measured 5204.25 5530.11 1.06261
kinesin-like protein kif2 (kinesin-2) (hk2). [swissprot;acc:o00139] Squared 23935.3 26185.1 1.094
1902 alpha/beta hydrolase domain containing protein 3; lung alpha/beta hydrolase 3. [refseq;acc:nm_138340] Rooted 63.4353 65.2789 1.02906
inorganic pyrophosphatase 2 isoform 1. [refseq;acc:nm_176869] Measured 5204.25 5530.11 1.06261
lamin b receptor (integral nuclear envelope inner membrane protein) (lmn2r). [swissprot;acc:q14739] Ranked 191.411 193.39 1.01034
suppressor of cytokine signaling 1 (socs-1) (jak-binding protein) (jab) (stat induced stat inhibitor 1) (ssi-1) (tec-interacting protein 3) (tip-3). [swissprot;acc:o15524] Squared 27114.7 29663.3 1.09399
1903 aryl-hydrocarbon interacting protein-like 1. [swissprot;acc:q9nzn9] Measured 5204.25 5530.11 1.06261
glia maturation factor gamma (gmf-gamma). [swissprot;acc:o60234] Squared 27114.7 29663.3 1.09399
golgi membrane protein sb140; smooth muscle cell associated protein 5. [refseq;acc:nm_030799] Rooted 63.4353 65.2789 1.02906
solute carrier family 27 member 3; fatty acid transport protein 3. [refseq;acc:nm_024330] Ranked 191.406 193.385 1.01034
1904 ah receptor-interacting protein (aip) (immunophilin homolog ara9) (hbv-x associated protein 2). [swissprot;acc:o00170] Measured 5204.25 5530.11 1.06261
alpha/beta hydrolase domain containing protein 1 isoform 2; lung alpha/beta hydrolase protein 1. [refseq;acc:nm_152870] Rooted 63.4353 65.2789 1.02906
asc-1 complex subunit p100. [refseq;acc:nm_032204] Squared 27114.7 29663.3 1.09399
very-long-chain acyl-coa synthetase (ec 6.2.1.-) (very-long-chain- fatty-acid-coa ligase). [swissprot;acc:o14975] Ranked 191.424 193.404 1.01034
1905 6-phosphofructokinase, liver type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme b) (pfk-b). [swissprot;acc:p17858] Rooted 52.8713 54.4076 1.02906
disrupter of silencing 10. [refseq;acc:nm_020368] Ranked 191.411 193.39 1.01034
fk506-binding protein 1a (ec 5.2.1.8) (peptidyl-prolyl cis-trans isomerase) (ppiase) (rotamase) (12 kda fkbp) (fkbp-12) (immunophilin fkbp12). [swissprot;acc:p20071] Squared 27114.7 29663.3 1.09399
son of sevenless protein homolog 2 (sos-2). [swissprot;acc:q07890] Measured 7497.96 7967.09 1.06257
1906 60s ribosomal protein l10a (csa-19). [swissprot;acc:p53025] Squared 12688.5 13880.9 1.09397
methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial precursor (ec 1.2.1.27) (mmsdh). [swissprot;acc:q02252] Rooted 63.4354 65.279 1.02906
mitochondrial ribosomal protein l18. [refseq;acc:nm_014161] Measured 5396.61 5733.93 1.06251
very long-chain acyl-coa synthetase homolog 1. [refseq;acc:nm_014031] Ranked 191.41 193.389 1.01034
1907 10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984] Rooted 63.4353 65.2789 1.02906
hepatitis c virus core-binding protein 6; cervical cancer oncogene 3. [refseq;acc:nm_023934] Measured 6858.84 7287.27 1.06246
ny-ren-62 antigen (fragment). [sptrembl;acc:q9y590] Squared 23928.1 26176.4 1.09396
solute carrier family 27 (fatty acid transporter), member 5; very long-chain acyl-coa synthetase homolog 2; very long-chain acyl-coa synthetase-related protein; likely ortholog of mouse solute carrier family 27 (fatty acid transporter), member 5. [refseq;acc:nm_012254] Ranked 191.408 193.387 1.01034
1908 adenylate kinase isoenzyme 4, mitochondrial (ec 2.7.4.3) (atp-amp transphosphorylase). [swissprot;acc:p27144] Squared 12725.1 13920.6 1.09395
dc11 protein. [refseq;acc:nm_020186] Measured 6858.84 7287.27 1.06246
rab acceptor 1 (prenylated); prenylated rab acceptor 1. [refseq;acc:nm_006423] Rooted 63.4353 65.2789 1.02906
similar to cg7020 gene product (fragment). [sptrembl;acc:q96ib4] Ranked 191.415 193.394 1.01034
1909 amyloid beta precursor protein-binding protein 1; amyloid protein-binding protein 1. [refseq;acc:nm_003905] Measured 6858.84 7287.27 1.06246
calmegin precursor. [swissprot;acc:o14967] Ranked 217.48 215.256 1.01033
oligoribonuclease, mitochondrial precursor (ec 3.1.-.-) (small fragment nuclease) (cgi-114). [swissprot;acc:q9y3b8] Rooted 63.4353 65.2789 1.02906
surfeit locus protein 5. [swissprot;acc:q15528] Squared 12724.9 13920.4 1.09395
1910 5-aminolevulinic acid synthase, erythroid-specific, mitochondrial precursor (ec 2.3.1.37) (delta-aminolevulinate synthase) (delta-ala synthetase) (alas-e). [swissprot;acc:p22557] Measured 6858.84 7287.27 1.06246
calnexin precursor (major histocompatibility complex class i antigen-binding protein p88) (p90) (ip90). [swissprot;acc:p27824] Ranked 217.48 215.256 1.01033
choline o-acetyltransferase (ec 2.3.1.6) (choactase) (choline acetylase) (chat). [swissprot;acc:p28329] Rooted 63.4354 65.279 1.02906
gtp:amp phosphotransferase mitochondrial (ec 2.7.4.10) (ak3) (adenylate kinase 3 alpha like 1). [swissprot;acc:q9uij7] Squared 12724.8 13920.3 1.09395

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/