MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Rank	Gene	description	Value Type	Network Comparison Type	Filtered	Interaction Map	network_comparison	red	green

Results: HTML CSV LaTeX

Showing element 501 to 550 of 12912 in total

Network Comparison Type  : Divided
Filtered  : 1
Interaction Map  : High confidence

Rank	description	Value Type	network_comparison	red	green
126	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	Ranked	1.21277	94	114
	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	Measured	1.33499	24250	18164.9
	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	Rooted	1.23311	60.9342	75.1387
	serine/threonine protein phosphatase pp1-alpha 1 catalytic subunit (ec 3.1.3.16) (pp-1a). [swissprot;acc:p08129]	Squared	1.52616	189976	124480
127	cyclin-dependent kinases regulatory subunit 1 (cks-1) (sid1334) (pnas-16 / pnas-143). [swissprot;acc:p33551]		1.51365	88432.6	58423.3
	high-mobility group 20a. [refseq;acc:nm_018200]	Rooted	1.23236	60.9353	75.094
	putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453]	Ranked	1.21277	94	114
	transcription factor jun-d. [swissprot;acc:p17535]	Measured	1.33436	5638.2	7523.39
128	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]	Ranked	1.21277	94	114
	luc7-like 2; cgi-74 protein; cgi-59 protein. [refseq;acc:nm_016019]	Measured	1.3341	4355.61	5810.82
	pnas-18. [sptrembl;acc:q9bzu3]	Squared	1.50952	87787.3	58155.8
	tar dna-binding protein-43 (tdp-43). [swissprot;acc:q13148]	Rooted	1.23069	48.0515	39.0445
129	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]		1.23044	54.2343	66.7323
	luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032]	Measured	1.33348	4358.13	5811.49
	neuroendocrine differentiation factor; comparative gene identification transcript 149. [refseq;acc:nm_016079]	Ranked	1.21277	94	114
	pre-mrna cleavage complex ii protein pcf11 (fragment). [swissprot;acc:o94913]	Squared	1.50257	178263	118639
130	44050 protein. [refseq;acc:nm_178832]		1.4861	148058	99628.4
	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]	Measured	1.33287	2234.68	2978.53
	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	Rooted	1.22626	55.1026	67.5701
	protein hspc134 (protein cda04). [swissprot;acc:q9by43]	Ranked	1.21277	94	114
131	forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	Measured	1.33285	2234.73	2978.57
	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	Rooted	1.22577	55.1113	67.5537
	nuclear inhibitor of protein phosphatase-1 (nipp-1) (protein phosphatase 1, regulatory inhibitor subunit 8) [includes: activator of rna decay (ec 3.1.4.-) (ard-1)]. [swissprot;acc:q12972]	Squared	1.4861	148058	99628.4
	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]	Ranked	1.21228	294.053	242.562
132	autophagy protein 5-like (apg5-like) (apoptosis-specific protein). [swissprot;acc:q9h1y0]	Squared	1.48606	36359.2	24466.8
	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]	Measured	1.33253	2236.61	2980.35
	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	Rooted	1.22451	44.963	55.0576
	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	Ranked	1.2069	350	290
133	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	Measured	1.33225	23421.5	17580.4
	gbp protein isoform a. [refseq;acc:nm_017870]	Squared	1.46039	1182.25	1726.55
	odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260]	Rooted	1.22316	45.4558	55.5995
	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	Ranked	1.2069	350	290
134	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]
	dna polymerase epsilon p12 subunit (dna polymerase epsilon subunit 4). [swissprot;acc:q9nr33]	Rooted	1.2218	44.849	54.7964
	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]	Measured	1.32626	21785.2	16426.1
	p66 alpha. [refseq;acc:nm_017660]	Squared	1.45434	81888.8	56306.5
135	20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	Rooted	1.21253	54.935	66.6101
	apg3p; pc3-96 protein. [refseq;acc:nm_022488]	Measured	1.32626	21785.2	16426.1
	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	Ranked	1.2069	350	290
	transcription repressor p66 beta component of the mecp1 complex. [refseq;acc:nm_020699]	Squared	1.45434	81888.8	56306.5
136	adiponectin receptor 2. [refseq;acc:nm_024551]	Rooted	1.21061	41.8357	50.6469
	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	Ranked	1.2069	350	290
	nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952]	Measured	1.31556	3620.77	4763.34
	tyrosine aminotransferase (ec 2.6.1.5) (l-tyrosine:2-oxoglutarate aminotransferase) (tat). [swissprot;acc:p17735]	Squared	1.45434	81888.8	56306.5
137	ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]	Measured	1.31556	3620.77	4763.34
	cell division protein kinase 3 (ec 2.7.1.-). [swissprot;acc:q00526]	Squared	1.45167	81606.8	56215.8
	musashi 2 isoform a. [refseq;acc:nm_138962]	Rooted	1.20486	54.9787	66.2416
	ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]	Ranked	1.2069	350	290
138	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592]	Measured	1.31555	2755.15	2094.3
	musashi 1. [refseq;acc:nm_002442]	Rooted	1.20486	54.9787	66.2416

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.