Scientific

MK5 Microarray Data


Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 7264 to 7313 of 8289 in total
Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : Low confidence
Filtered  : 1
Rank
description
red
green
network_comparison
4036 g1 to s phase transition protein 1 homolog (gtp-binding protein gst1-hs). [swissprot;acc:p15170] 201.529 199.243 1.01147
4037 78 kda glucose-regulated protein precursor (grp 78) (immunoglobulin heavy chain binding protein) (bip) (endoplasmic reticulum lumenal ca(2+) binding protein grp78). [swissprot;acc:p11021] 206.348 204.01 1.01146
4038 pinch protein (particularly interesting new cys-his protein) (lim and senescent cell antigen-like domains 1). [swissprot;acc:p48059] 204.044 201.734 1.01145
4039 ketohexokinase (ec 2.7.1.3) (hepatic fructokinase). [swissprot;acc:p50053] 201.178 198.902 1.01144
4040 interleukin enhancer-binding factor 1 (cellular transcription factor ilf-1). [swissprot;acc:q01167] 207.031 204.695 1.01141
4041 multifunctional protein ade2 [includes: phosphoribosylaminoimidazole- succinocarboxamide synthase (ec 6.3.2.6) (saicar synthetase); phosphoribosylaminoimidazole carboxylase (ec 4.1.1.21) (air carboxylase) (airc)]. [swissprot;acc:p22234] 201.513 199.24
4042 tubulin alpha-8 chain (alpha-tubulin 8). [swissprot;acc:q9ny65] 200.436 198.176 1.0114
4043 swi/snf-related matrix-associated actin-dependent regulator of chromatin c2 isoform a; mammalian chromatin remodeling complex brg1-associated factor 170; chromatin remodeling complex baf170 subunit; swi3-like protein; swi/snf complex 170 kda subunit. [refseq;acc:nm_003075] 204.37 202.07 1.01138
4044 probable mitochondrial import receptor subunit tom40 homolog (translocase of outer membrane 40 kda subunit homolog) (haymaker protein) (p38.5). [swissprot;acc:o96008] 201.62 199.351
4045 cholinephosphate cytidylyltransferase a (ec 2.7.7.15) (phosphorylcholine transferase a) (ctp:phosphocholine cytidylyltransferase a) (ct a) (cct a) (cct-alpha). [swissprot;acc:p49585] 197.07 194.855 1.01137
4046 mct-1 protein. [refseq;acc:nm_014060] 204.839 202.536
4047 cholinephosphate cytidylyltransferase b (ec 2.7.7.15) (phosphorylcholine transferase b) (ctp:phosphocholine cytidylyltransferase b) (ct b) (cct b) (cct-beta). [swissprot;acc:q9y5k3] 197.058 194.846 1.01135
4048 nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-75kd) (ci-75kd). [swissprot;acc:p28331] 204.634 202.337
4049 voltage-gated potassium channel beta-1 subunit (k+ channel beta-1 subunit) (kv-beta-1). [swissprot;acc:q14722] 198.466 196.24 1.01134
4050 sorting nexin 12. [swissprot;acc:q9umy4] 202.534 200.264
4051 sorting nexin 3 (sdp3 protein). [swissprot;acc:o60493]
4052 sumo-1 activating enzyme subunit 2. [refseq;acc:nm_005499] 202.388 200.121 1.01133
4053 voltage-gated potassium channel beta-2 subunit (k+ channel beta-2 subunit) (kv-beta-2) (hkvbeta2). [swissprot;acc:q13303] 198.46 196.237
4054 voltage-gated potassium channel beta-3 subunit (k+ channel beta-3 subunit) (kv-beta-3). [swissprot;acc:o43448] 198.458 1.01132
4055 mevalonate kinase (ec 2.7.1.36) (mk). [swissprot;acc:q03426] 204.276 202.002 1.01126
4056 inhibitor of growth family, member 1-like; inhibitor of growth 1-like. [refseq;acc:nm_001564] 202.985 200.726 1.01125
4057 origin recognition complex subunit 4. [swissprot;acc:o43929] 199.228 201.468 1.01124
4058 sphingosine kinase 1 (ec 2.7.1.-) (sk 1) (spk 1). [swissprot;acc:q9nya1] 204.671 202.399 1.01123
4059 ad037 protein isoform a. [refseq;acc:nm_032023] 202.985 200.731
4060 ras association domain family 2. [swissprot;acc:p50749]
4061 inhibitor of growth family, member 1; inhibitor of growth 1. [refseq;acc:nm_005537] 200.736 1.0112
4062 homeobox protein emx2. [swissprot;acc:q04743] 195.986 193.817 1.01119
4063 proteasome subunit alpha type 7 (ec 3.4.25.1) (proteasome subunit rc6-1) (proteasome subunit xapc7). [swissprot;acc:o14818] 201.061 198.836
4064 protein phosphatase methylesterase-1. [refseq;acc:nm_016147] 199.57 201.799 1.01117
4065 proteasome subunit alpha type 7-like (ec 3.4.25.1). [swissprot;acc:q8taa3] 201.078 198.856
4066 fh1/fh2 domains-containing protein (formin homolog overexpressed in spleen) (fhos) (formin homology 2 domain containing 1). [swissprot;acc:q9y613] 199.937 197.729
4067 proteasome subunit beta type 3 (ec 3.4.25.1) (proteasome theta chain) (proteasome chain 13) (proteasome component c10-ii). [swissprot;acc:p49720]
4068 pyruvate kinase, m1 isozyme (ec 2.7.1.40) (pyruvate kinase muscle isozyme) (cytosolic thyroid hormone-binding protein) (cthbp) (thbp1). [swissprot;acc:p14618] 208.371 210.696 1.01116
4069 insulin gene enhancer protein isl-2 (islet-2). [swissprot;acc:q96a47] 203.708 201.464 1.01114
4070 filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457] 190.559 188.462 1.01113
4071 metaxin 1. [swissprot;acc:q13505] 199.191 197.001 1.01112
4072 neurogenic locus notch homolog protein 1 precursor (notch 1) (hn1) (translocation-associated notch protein tan-1). [swissprot;acc:p46531] 201.952 199.732 1.01111
4073 neurogenic locus notch homolog protein 2 precursor (notch 2) (hn2). [swissprot;acc:q04721]
4074 dna-repair protein xrcc3 (x-ray repair cross-complementing protein 3). [swissprot;acc:o43542] 202.57 200.345
4075 adp-ribosylation factor-like protein 1. [swissprot;acc:p40616] 200.896 198.695 1.01108
4076 thymus-specific serine protease precursor (ec 3.4.-.-). [swissprot;acc:q9nqe7] 200.22 198.028 1.01107
4077 mitogen-activated protein kinase kinase kinase 5 (ec 2.7.1.-) (mapk/erk kinase kinase 5) (mek kinase 5) (mekk 5) (apoptosis signal- regulating kinase 1) (ask-1). [swissprot;acc:q99683] 201.604 199.397
4078 mitochondrial 28s ribosomal protein s22 (s22mt) (mrp-s22) (gk002). [swissprot;acc:p82650] 199.894 197.711 1.01104
4079 nefa-interacting nuclear protein nip30. [refseq;acc:nm_024946]
4080 proteasome subunit beta type 2 (ec 3.4.25.1) (proteasome component c7-i) (macropain subunit c7-i) (multicatalytic endopeptidase complex subunit c7-i). [swissprot;acc:p49721]
4081 bone morphogenetic protein 4 precursor (bmp-4) (bmp-2b). [swissprot;acc:p12644] 195.995 193.854
4082 positive cofactor 2 glutamine/q-rich-associated protein (pc2 glutamine/q-rich-associated protein) (tpa-inducible gene-1) (tig-1) (activator-recruited cofactor 105 kda component) (arc105) (ctg repeat protein 7a). [swissprot;acc:q96rn5] 199.894 197.711
4083 myosin light chain kinase, smooth muscle and non-muscle isozymes (ec 2.7.1.117) (mlck) [contains: telokin (kinase related protein) (krp)]. [swissprot;acc:q15746]
4084 heterogeneous nuclear ribonucleoprotein l (hnrnp l). [swissprot;acc:p14866] 203.632 201.42 1.01098
4085 downstream of son gene protein (b17). [swissprot;acc:q9nyp3] 201.76 199.573 1.01096

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.

- http://analysis.yellowcouch.org/