MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Network Comparison Type	Value Type	Gene	description	Rank	Filtered	Interaction Map	network_comparison	red	green

Results: HTML CSV LaTeX

Showing element 968 to 1017 of 3228 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1
Interaction Map  : High confidence

description	Rank	network_comparison	red	green
eukaryotic translation initiation factor 2 subunit 2 (eukaryotic translation initiation factor 2 beta subunit) (eif-2-beta). [swissprot;acc:p20042]	1839	1.01118	221.525	224.001
eukaryotic translation initiation factor 2 subunit 3 (eukaryotic translation initiation factor 2 gamma subunit) (eif-2-gamma). [swissprot;acc:p41091]	1865	1.01086	221.639	224.046
eukaryotic translation initiation factor 3 subunit 10 (eif-3 theta) (eif3 p167) (eif3 p180) (eif3 p185) (eif3a). [swissprot;acc:q14152]	904	1.03849	246.354	237.223
eukaryotic translation initiation factor 3 subunit 11 (eif-3 p25) (eif3k) (muscle specific gene m9 protein) (ptd001) (hspc029) (arg134). [swissprot;acc:q9ubq5]	1565	1.01646	221.128	224.767
eukaryotic translation initiation factor 3 subunit 2 (eif-3 beta) (eif3 p36) (eif3i) (tgf-beta receptor interacting protein 1) (trip-1). [swissprot;acc:q13347]	746	1.0507	250.465	238.38
eukaryotic translation initiation factor 3 subunit 4 (eif-3 delta) (eif3 p44) (eif-3 rna-binding subunit) (eif3 p42) (eif3g). [swissprot;acc:o75821]	903	1.03849	246.354	237.223
eukaryotic translation initiation factor 3 subunit 6 interacting protein (hspc021/hspc025). [swissprot;acc:q9y262]	1571	1.01646	221.128	224.767
eukaryotic translation initiation factor 3 subunit 7 (eif-3 zeta) (eif3 p66) (eif3d). [swissprot;acc:o15371]	1931	1.01001	219.753	217.574
eukaryotic translation initiation factor 3 subunit 8 (eif3 p110) (eif3c). [swissprot;acc:q99613]	1405	1.021	245.532	240.483
eukaryotic translation initiation factor 3 subunit 9 (eif-3 eta) (eif3 p116) (eif3 p110) (eif3b). [swissprot;acc:p55884]	822	1.04408	243.067	232.805
eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]	252	1.11689	237.292	212.457
eukaryotic translation initiation factor 4 gamma, 3. [refseq;acc:nm_003760]	246	1.11748	237.312	212.363
eukaryotic translation initiation factor 4e (eif-4e) (eif4e) (mrna cap-binding protein) (eif-4f 25 kda subunit). [swissprot;acc:p06730]	649	1.05877	233.725	220.751
eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]	268	1.10996	271.016	244.167
eukaryotic translation initiation factor 5a (eif-5a) (eif-4d) (rev- binding factor). [swissprot;acc:p10159]	2102	1.00736	208.727	210.263
eukaryotic translation initiation factor 6 (eif-6) (b4 integrin interactor) (cab) (p27(bbp)) (b(2)gcn homolog). [swissprot;acc:p56537]	545	1.06678	248.866	233.287
evolutionarily conserved g-patch domain containing. [refseq;acc:nm_018025]	573	1.06504	227.86	213.945
evolutionarily conserved signaling intermediate in toll pathway; ecsit. [refseq;acc:nm_016581]	2092	1.00772	211.992	210.369
exocyst complex component exo70. [swissprot;acc:q9upt5]	2781	1	0.00001	0.00001
exocyst complex component sec10 (hsec10). [swissprot;acc:o00471]	721	1.0538	214.765	203.8
exocyst complex component sec15a. [swissprot;acc:q8tag9]	750	1.05028	222.138	211.503
exocyst complex component sec15b. [swissprot;acc:q9y2d4]	749	1.05036	221.968	211.326
exocyst complex component sec3 (bm-012). [swissprot;acc:q9nv70]	2487	1.00287	218.093	218.72
exocyst complex component sec5. [swissprot;acc:q96kp1]	986	1.03371	116.771	120.707
exocyst complex component sec6. [swissprot;acc:o60645]	981	1.03387	207.186	200.398
exocyst complex component sec8. [swissprot;acc:q96a65]	869	1.03969	217.762	209.449
exonuclease 1 isoform b; rad2 nuclease family member, homolog of s. cerevisiae exonuclease 1. [refseq;acc:nm_006027]	1344	1.02224	216.772	221.594
exosome complex exonuclease rrp4 (ec 3.1.13.-) (ribosomal rna processing protein 4). [swissprot;acc:q13868]	523	1.06891	215.237	230.07
exosome complex exonuclease rrp40 (ec 3.1.13.-) (ribosomal rna processing protein 40) (p10) (cgi-102). [swissprot;acc:q9nqt5]	524
exosome complex exonuclease rrp41 (ec 3.1.13.-) (ribosomal rna processing protein 41) (p12a). [swissprot;acc:q9npd3]	521
exosome complex exonuclease rrp46 (ec 3.1.13.-) (ribosomal rna processing protein 46) (p12b) (chronic myelogenous leukemia tumor antigen 28). [swissprot;acc:q9nqt4]	525
exportin 1; exportin-1 (required for chromosome region maintenance); exportin 1 (crm1, yeast, homolog); crm1, yeast, homolog. [refseq;acc:nm_003400]	1497	1.01866	224.476	220.363
eyes absent homolog 1. [swissprot;acc:q99502]	1396	1.02147	218.463	213.872
eyes absent homolog 2. [swissprot;acc:o00167]	1399	1.02137	218.417	213.848
eyes absent homolog 3. [swissprot;acc:q99504]	1376	1.02163	218.537	213.91
eyes absent homolog 4. [swissprot;acc:o95677]	1398	1.02144	218.449	213.864
ezrin-binding partner pace-1 isoform 1. [refseq;acc:nm_020423]	3228	1	0.00001	0.00001
f-actin capping protein alpha-1 subunit (capz alpha-1). [swissprot;acc:p52907]	1824	1.0115	214.722	212.281
f-actin capping protein alpha-2 subunit (capz alpha-2). [swissprot;acc:p47755]	1831	1.01139	214.746	212.328
f-actin capping protein alpha-3 subunit (capz alpha-3) (germ cell- specific protein 3). [swissprot;acc:q96kx2]	2032	1.00872	215.322	213.46
f-actin capping protein beta subunit (capz beta). [swissprot;acc:p47756]	2033
f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	209	1.13261	285.684	252.234
fad synthetase. [refseq;acc:nm_025207]	270	1.10763	241.373	267.352
far upstream element-binding protein; far upstream element binding protein; fuse-binding protein. [refseq;acc:nm_003902]	2656	1.00109	217.179	216.943
farnesyl pyrophosphate synthetase (fpp synthetase) (fps) (farnesyl diphosphate synthetase) [includes: dimethylallyltransferase (ec 2.5.1.1); geranyltranstransferase (ec 2.5.1.10)]. [swissprot;acc:p14324]	2462	1.00308	235.812	235.088
fas apoptotic inhibitory molecule. [refseq;acc:nm_018147]	2068	1.0082	220.8	222.61
fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402]	1442	1.02015	225.039	229.573
fatty acid desaturase 2; linoleoyl-coa desaturase (delta-6-desaturase)-like 2; delta-6 fatty acid desaturase. [refseq;acc:nm_004265]	1441
fatty acid desaturase 3; linoleoyl-coa desaturase (delta-6-desaturase)-like 3; delta-6 fatty acid desaturase. [refseq;acc:nm_021727]	1439
fatty acid hydroxylase domain containing 1. [refseq;acc:nm_024306]	1536	1.01732	228.419	232.376

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.