Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Gene Rank Filtered description Network Comparison Type Value Type Interaction Map red network_comparison green
Results: HTML CSV LaTeX Showing element 451 to 500 of 3730 in total 
Network Comparison Type	Divided
Value Type	Ranked
Interaction Map	High confidence

Rank	Filtered	description	red	network_comparison	green	
226	0	rab gdp dissociation inhibitor alpha (rab gdi alpha) (gdi-1) (xap-4) (oligophrenin 2). [source:swissprot;acc:p31150]	15395.7	1.10374	16992.9	
226	1	cartilage oligomeric matrix protein precursor (comp). [source:swissprot;acc:p49747]	239.991	1.12187	269.238	
227	0	tigger transposable element derived 6. [source:refseq;acc:nm_030953]	12360	1.10355	11200.2	
227	1	thrombospondin 3 precursor. [source:swissprot;acc:p49746]	239.99	1.12186	269.234	
228	0	soluble liver antigen/liver pancreas antigen. [source:refseq;acc:nm_153825]	10303.5	1.10355	11370.4	
228	1	sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [source:refseq;acc:nm_005489]	226.411	1.12036	202.088	
229	0	poly (adp-ribose) glycohydrolase. [source:refseq;acc:nm_003631]	10899.4	1.10339	9878.1	
229	1	breast cancer antiestrogen resistance 3. [source:refseq;acc:nm_003567]	226.401	1.12028	202.094	
230	0	tigger transposable element derived 7; jerky (mouse) homolog-like. [source:refseq;acc:nm_033208]	12364.7	1.10323	11207.7	
230	1	cysteine-rich protein 1 (crp1) (crp). [source:swissprot;acc:p21291]	239.35	1.11934	267.915	
231	0	tigger transposable element derived 1; jerky (mouse) homolog-like. [source:refseq;acc:nm_145702]	12364.8	1.10322	11207.9	
231	1	likely ortholog of mouse shc sh2-domain binding protein 1. [source:refseq;acc:nm_024745]	239.336	1.11927	267.881	
232	0	kynureninase (ec 3.7.1.3) (l-kynurenine hydrolase). [source:swissprot;acc:q16719]	12394.7	1.10271	11240.2	
232	1	smooth muscle cell lim protein (cysteine-rich protein 2) (crp2) (lim-only protein 5). [source:swissprot;acc:q16527]	239.336	1.11926	267.879	
233	0	60s acidic ribosomal protein p1. [source:swissprot;acc:p05386]	9586.97	1.1015	10560	
233	1	lim domain protein, cardiac (muscle lim protein) (cysteine-rich protein 3) (crp3). [source:swissprot;acc:p50461]	239.32	1.11918	267.842	
234	0	transcription factor 4 (immunoglobulin transcription factor 2) (itf-2) (sl3-3 enhancer factor 2) (sef-2). [source:swissprot;acc:p15884]	16614	1.10124	18296	
234	1	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [source:swissprot;acc:q9nrg0]	287.41	1.11905	256.835	
235	0	elongation factor 1-alpha 1 (ef-1-alpha-1) (elongation factor 1 a-1) (eef1a-1) (elongation factor tu) (ef-tu). [source:swissprot;acc:p04720]	14554.5	1.10123	16027.9	
235	1	phenylalanine-4-hydroxylase (ec 1.14.16.1) (pah) (phe-4- monooxygenase). [source:swissprot;acc:p00439]	227.357	1.11785	254.15	
236	0	protein phosphatase inhibitor 2 (ipp-2). [source:swissprot;acc:p41236]	15245.4	1.10122	16788.5	
236	1	pp3111 protein. [source:refseq;acc:nm_022156]	227.357	1.11785	254.15	
237	0	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 (paps synthethase 2) (papss 2) (sulfurylase kinase 2) (sk2) (sk 2) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [source:swissprot;acc:o95340]	9984	1.10114	9067	
237	1	syntaxin 18. [source:swissprot;acc:q9p2w9]	227.357	1.11785	254.15	
238	0	cyclin-dependent kinases regulatory subunit 1 (cks-1) (sid1334) (pnas-16 / pnas-143). [source:swissprot;acc:p33551]	12677.7	1.0997	13941.7	
238	1	rd protein. [source:swissprot;acc:p18615]	227.357	1.11785	254.15	
239	0	mto1 protein homolog (cgi-02). [source:swissprot;acc:q9y2z2]	8907.41	1.09969	9795.36	
239	1	glutathione transferase omega 1 (ec 2.5.1.18) (gsto 1-1). [source:swissprot;acc:p78417]	227.357	1.11785	254.15	
240	0	methyltransferase like 2. [source:refseq;acc:nm_018396]	17946	1.09923	16326	
240	1	androgen-induced 1; cgi-103 protein; androgen induced protein. [source:refseq;acc:nm_016108]	227.357	1.11785	254.15	
241	0	secreted modular calcium-binding protein 1. [source:refseq;acc:nm_022137]	14003.7	1.09891	12743.3	
241	1	atp synthase b chain, mitochondrial precursor (ec 3.6.3.14). [source:swissprot;acc:p24539]	227.357	1.11785	254.15	
242	0	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [source:swissprot;acc:q04446]	15260.6	1.09822	13895.8	
242	1	j domain containing protein 1. [source:swissprot;acc:q9ukb3]	227.357	1.11785	254.15	
243	0	polyadenylate-binding protein 3 (poly(a)-binding protein 3) (pabp 3) (testis-specific poly(a)-binding protein). [source:swissprot;acc:q9h361]	1251	1.09752	1373	
243	1	sorting nexin 13 (rgs domain- and phox domain-containing protein) (rgs-px1). [source:swissprot;acc:q9y5w8]	227.357	1.11785	254.15	
244	0	keratin associated protein 9.2. [source:refseq;acc:nm_031961]	10551.1	1.09751	11579.9	
244	1	ba127l20.1 (novel glutathione-s-transferase). [source:sptrembl;acc:q9h4y5]	227.357	1.11785	254.15	
245	0	cell division protein kinase 3 (ec 2.7.1.-). [source:swissprot;acc:q00526]	11867.6	1.09702	13019	
245	1	small nuclear ribonucleoprotein sm d3 (snrnp core protein d3) (sm-d3). [source:swissprot;acc:p43331]	226.109	1.11751	202.333	
246	0	keratin associated protein 4.3 (fragment). [source:sptrembl;acc:q9byr4]	10551.6	1.09687	11573.7	
246	1	eukaryotic translation initiation factor 4 gamma, 3. [source:refseq;acc:nm_003760]	237.312	1.11748	212.363	
247	0	keratin associated protein 2-4; keratin associated protein 2.4. [source:refseq;acc:nm_033184]	10551.6	1.09687	11573.7	
247	1	rna-binding protein. [source:refseq;acc:nm_019027]	237.302	1.11719	212.41	
248	0	keratin associated protein 1.5. [source:refseq;acc:nm_031957]	10551.6	1.09687	11573.7	
248	1	apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [source:refseq;acc:nm_014576]	237.302	1.11719	212.41	
249	0	keratin, ultra high-sulfur matrix protein a (uhs keratin a) (uhs kera). [source:swissprot;acc:p26371]	10551.6	1.09687	11573.7	
249	1	ns1-associated protein 1. [source:refseq;acc:nm_006372]	237.302	1.11719	212.41	
250	0	keratin associated protein 1-3; keratin associated protein 1.3. [source:refseq;acc:nm_030966]	10551.6	1.09687	11573.7	
250	1	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [source:swissprot;acc:o43390]	237.302	1.11719	212.41	

Legend:
- Rank is the rank after comparing the two networks
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/