Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Gene Rank Value Type description Interaction Map green Network Comparison Type Filtered red network_comparison
Results: HTML CSV LaTeX Showing element 451 to 500 of 16578 in total
Value Type  : Ranked
Filtered  : 1
Rank
description
Interaction Map
green
Network Comparison Type
red
network_comparison
113 natural resistance-associated macrophage protein 2 (nramp 2) (divalent metal transporter 1) (dmt1). [swissprot;acc:p49281] Low confidence 210.566 Subtracted 224.763 14.197
serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323] High confidence 234.204 194.372 39.832
114 28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5] Low confidence 44 58 14
b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681] High confidence 267.265 229.818 37.447
disks large-associated protein 1 (dap-1) (guanylate kinase-associated protein) (hgkap) (sap90/psd-95-associated protein 1) (sapap1) (psd- 95/sap90 binding protein 1). [swissprot;acc:o14490] Low confidence 211.983 Divided 197.779 1.07182
kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559] High confidence 267.246 332.874 1.24557
115 disks large-associated protein 4 (dap-4) (sap90/psd-95-associated protein 4) (sapap4) (psd-95/sap90 binding protein 4). [swissprot;acc:q9y2h0] Low confidence 211.983 197.779 1.07182
histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929] High confidence 240.461 Subtracted 277.546 37.085
kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688] 267.246 Divided 332.874 1.24557
mitochondrial solute carrier protein. [refseq;acc:nm_145305] Low confidence 44 Subtracted 58 14
116 guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520] High confidence 334.483 Divided 268.565 1.24545
high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339] 171.595 Subtracted 208.52 36.925
testican-3 precursor. [swissprot;acc:q9bq16] Low confidence 234.389 220.395 13.994
vacuolar protein sorting 18 (hvps18). [swissprot;acc:q9p253] 190.791 Divided 204.161 1.07008
117 coagulation factor xiii a chain precursor (ec 2.3.2.13) (protein- glutamine gamma-glutamyltransferase a chain) (transglutaminase a chain). [swissprot;acc:p00488] 211.713 226.395 1.06935
high-mobility group 20a. [refseq;acc:nm_018200] High confidence 171.778 Subtracted 208.588 36.81
neuralized-like. [refseq;acc:nm_004210] 266.948 Divided 332.326 1.24491
striated muscle activator of rho-dependent signaling. [refseq;acc:nm_139166] Low confidence 211.529 Subtracted 225.495 13.966
118 nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09] High confidence 228.934 Divided 284.753 1.24382
odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260] 237.79 Subtracted 274.027 36.237
protein-glutamine gamma-glutamyltransferase k (ec 2.3.2.13) (transglutaminase k) (tgase k) (tgk) (tg(k)) (transglutaminase 1) (epidermal tgase). [swissprot;acc:p22735] Low confidence 211.713 Divided 226.395 1.06935
testican-1 precursor (spock protein). [swissprot;acc:q08629] 234.111 Subtracted 220.254 13.857
119 adiponectin receptor 2. [refseq;acc:nm_024551] High confidence 246.371 281.582 35.211
nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181] 259.004 Divided 318.982 1.23157
natural resistance-associated macrophage protein 1 (nramp 1). [swissprot;acc:p49279] Low confidence 211.107 225.666 1.06897
testican-2 precursor. [swissprot;acc:q92563] 234.047 Subtracted 220.222 13.825
120 nanos (fragment). [sptrembl;acc:q8wy41] 217.479 203.66 13.819
nucleolysin tia-1 (rna-binding protein tia-1) (p40-tia-1) [contains: p15-tia-1]. [swissprot;acc:p31483] High confidence 192.715 227.199 34.484
potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281] 327.709 Divided 269.278 1.21699
segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640] Low confidence 189.965 203.016 1.0687
121 cystathionine gamma-lyase (ec 4.4.1.1) (gamma-cystathionase). [swissprot;acc:p32929] High confidence 327.655 269.254 1.2169
nucleolysin tiar (tia-1 related protein). [swissprot;acc:q01085] 192.823 Subtracted 227.202 34.379
segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641] Low confidence 189.985 Divided 203.007 1.06854
vacuolar protein sorting 33a (hvps33a). [swissprot;acc:q96ax1] 190.189 Subtracted 203.914 13.725
122 cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653] High confidence 234.187 199.949 34.238
nanos (fragment). [sptrembl;acc:q8wy41] Low confidence 217.479 Divided 203.66 1.06785
potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980] High confidence 327.642 269.248 1.21688
vacuolar protein sorting 18 (hvps18). [swissprot;acc:q9p253] Low confidence 190.791 Subtracted 204.161 13.37
123 potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979] High confidence 327.601 Divided 269.23 1.21681
segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997] Low confidence 190.094 202.96 1.06768
small nuclear ribonucleoprotein sm d1 (snrnp core protein d1) (sm-d1) (sm-d autoantigen). [swissprot;acc:p13641] High confidence 193.056 Subtracted 227.032 33.976
striatin. [swissprot;acc:o43815] Low confidence 200.796 214.085 13.289
124 daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959] 206.997 220.268 13.271
high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339] High confidence 171.595 Divided 208.52 1.21519
natural resistance-associated macrophage protein 2 (nramp 2) (divalent metal transporter 1) (dmt1). [swissprot;acc:p49281] Low confidence 210.566 224.763 1.06742
presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810] High confidence 252.234 Subtracted 285.684 33.45
125 b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681] Low confidence 227.616 Divided 213.243 1.0674
high-mobility group 20a. [refseq;acc:nm_018200] High confidence 171.778 208.588 1.21429
prominin-like protein 1 precursor (antigen ac133) (cd133 antigen). [swissprot;acc:o43490] Low confidence 206.997 Subtracted 220.268 13.271
s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991] High confidence 252.234 285.684 33.45

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/