MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Rank	Gene	Value Type	description	Network Comparison Type	Filtered	Interaction Map	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 610 to 659 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	description	Interaction Map	green	red	network_comparison
305	mitochondrial ribosomal protein l2. [refseq;acc:nm_015950]	High confidence	266.986	242.339	1.1017
306	60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914]		266.673	242.153	1.10126
	small nuclear ribonucleoprotein f (snrnp-f) (sm protein f) (sm-f) (smf). [swissprot;acc:q15356]	Low confidence	193.867	202.122	1.04258
307	phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (ec 2.7.1.38) (phosphorylase kinase gamma subunit 1). [swissprot;acc:q16816]		227.209	217.957	1.04245
	serine racemase (ec 5.1.1.-). [swissprot;acc:q9gzt4]	High confidence	266.673	242.153	1.10126
308	60s ribosomal protein l34. [swissprot;acc:p49207]
	homer, neuronal immediate early gene, 2; homer homolog 3 (drosophila). [refseq;acc:nm_004839]	Low confidence	201.475	210.018	1.0424
309	microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378]		192.103	200.213	1.04222
	protein transport protein sec61 alpha subunit isoform 2 (sec61 alpha- 2). [swissprot;acc:q9y2r3]	High confidence	266.673	242.153	1.10126
310	nadh-ubiquinone oxidoreductase 39 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-39kd) (ci-39kd). [swissprot;acc:q16795]	Low confidence	197.484	205.75	1.04186
	protein transport protein sec61 alpha subunit isoform 1 (sec61 alpha- 1). [swissprot;acc:p38378]	High confidence	266.673	242.153	1.10126
311	protein translation factor sui1 homolog gc20. [swissprot;acc:o60739]		267.151	242.627	1.10108
	ubiquitin-activating enzyme e1c (uba3 homolog, yeast); ubiquitin-activating enzyme e1c (homologous to yeast uba3). [refseq;acc:nm_003968]	Low confidence	184.374	192.088	1.04184
312	60s ribosomal protein l3-like. [swissprot;acc:q92901]	High confidence	266.663	242.195	1.10103
	u2 small nuclear ribonucleoprotein a' (u2 snrnp-a'). [swissprot;acc:p09661]	Low confidence	193.937	202.051	1.04184
313	ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36]		193.94	202.05	1.04182
	ribonucleotide reductase m2 b (tp53 inducible); p53-inducible ribonucleotide reductase small subunit 2 homolog. [refseq;acc:nm_015713]	High confidence	211.207	232.473	1.10069
314	methionine aminopeptidase 1 (ec 3.4.11.18) (metap 1) (map 1) (peptidase m 1). [swissprot;acc:p53582]		268.604	244.126	1.10027
	splicing factor 3b subunit 1 (spliceosome associated protein 155) (sap 155) (sf3b155) (pre-mrna splicing factor sf3b 155 kda subunit). [swissprot;acc:o75533]	Low confidence	193.952	202.057	1.04179
315	methionine aminopeptidase 2 (ec 3.4.11.18) (metap 2) (peptidase m 2) (initiation factor 2 associated 67 kda glycoprotein) (p67) (p67eif2). [swissprot;acc:p50579]	High confidence	268.604	244.126	1.10027
	tankyrase 1 (ec 2.4.2.30) (tank1) (tankyrase i) (tnks-1) (trf1- interacting ankyrin-related adp-ribose polymerase). [swissprot;acc:o95271]	Low confidence	205.509	214.067	1.04164
316	potassium voltage-gated channel subfamily a member 2 (potassium channel kv1.2) (rbk2) (hbk5) (ngk1) (mk2) (hukiv). [swissprot;acc:p16389]		201.251	209.583	1.0414
	protein translation factor sui1 homolog (sui1iso1). [swissprot;acc:p41567]	High confidence	267.017	242.694	1.10022
317	potassium voltage-gated channel subfamily a member 1 (potassium channel kv1.1) (huki) (hbk1). [swissprot;acc:q09470]	Low confidence	201.251	209.58	1.04139
	splicing factor 3b subunit 3 (spliceosome associated protein 130) (sap 130) (sf3b130) (pre-mrna splicing factor sf3b 130 kda subunit). [swissprot;acc:q15393]	High confidence	204.044	224.445	1.09998
318	mitochondrial 60s ribosomal protein l3 (l3mt). [swissprot;acc:p09001]		266.18	242.011	1.09987
	potassium voltage-gated channel subfamily a member 4 (potassium channel kv1.4) (hk1) (hpcn2) (hbk4) (hukii). [swissprot;acc:p22459]	Low confidence	201.251	209.579	1.04138
319	60s ribosomal protein l19. [swissprot;acc:p14118]	High confidence	264.729	240.73	1.09969
	heat-shock protein, beta-2 (hspb2) (dmpk-binding protein) (mkbp). [swissprot;acc:q16082]	Low confidence	204.328	212.752	1.04123
320	epithelial-cadherin precursor (e-cadherin) (uvomorulin) (cadherin-1) (cam 120/80). [swissprot;acc:p12830]	High confidence	265.96	241.892	1.0995
	phosphorylase b kinase gamma catalytic chain, testis/liver isoform (ec 2.7.1.38) (phk-gamma-t) (phosphorylase kinase gamma subunit 2) (psk-c3). [swissprot;acc:p15735]	Low confidence	226.722	217.756	1.04117
321	c367g8.3 (novel protein similar to rpl23a (60s ribosomal protein l23a)) (60s ribosomal protein l23a like). [sptrembl;acc:q9br02]	High confidence	265.959	241.892	1.09949
	glioma tumor suppressor candidate region gene 2 protein (p60). [swissprot;acc:q9nzm5]	Low confidence	199.219	207.402	1.04108
322	cleavage and polyadenylation specific factor 5, 25 kd subunit; pre-mrna cleavage factor im (25kd); pre-mrna cleavage factor im, 25kd subunit. [refseq;acc:nm_007006]		203.991	212.262	1.04055
	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	High confidence	78.8995	86.7483	1.09948
323	60s ribosomal protein l23a. [swissprot;acc:p29316]		265.945	241.884	1.09947
	integrin beta-1 binding protein 2 (melusin) (mstp015). [swissprot;acc:q9ukp3]	Low confidence	203.991	212.262	1.04055
324	40s ribosomal protein s23. [swissprot;acc:p39028]	High confidence	268.195	243.944	1.09941
	rab3 gtpase-activating protein, non-catalytic subunit. [refseq;acc:nm_012414]	Low confidence	203.991	212.262	1.04055
325	28s ribosomal protein s12, mitochondrial precursor (mpr-s12) (mt- rps12). [swissprot;acc:o15235]	High confidence	268.195	243.944	1.09941
	source of immunodominant mhc-associated peptides; homolog of yeast stt3 gene. [refseq;acc:nm_178862]	Low confidence	192.123	199.905	1.04051
326	60s ribosomal protein l5. [swissprot;acc:p46777]	High confidence	265.924	241.899	1.09932
	dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kda subunit precursor (ec 2.4.1.119) (oligosaccharyl transferase 48 kda subunit) (ddost 48 kda subunit). [swissprot;acc:p39656]	Low confidence	191.59	199.343	1.04047
327	bet3 homolog. [swissprot;acc:o43617]		189.574	197.221	1.04034
	dna-directed rna polymerase ii largest subunit (ec 2.7.7.6) (rpb1). [swissprot;acc:p24928]	High confidence	267.962	243.817	1.09903
328	atp-dependent rna helicase ddx24 (dead-box protein 24). [swissprot;acc:q9gzr7]		235.183	258.437	1.09888
	splicing factor 3b subunit 2 (spliceosome associated protein 145) (sap 145) (sf3b150) (pre-mrna splicing factor sf3b 145 kda subunit). [swissprot;acc:q13435]	Low confidence	195.289	203.162	1.04031
329	exocyst complex component exo70. [swissprot;acc:q9upt5]		212.339	204.124	1.04025
	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]	High confidence	284	312	1.09859
330	chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.