MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Value Type	Gene	Network Comparison Type	Rank	network_comparison	Interaction Map	red	description	green	Filtered

Results: HTML CSV LaTeX

Showing element 2513 to 2562 of 3228 in total

Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	network_comparison	red	description	green
2513	1.02521	6204.25	reticulon 1 (neuroendocrine-specific protein). [swissprot;acc:q16799]	6360.69
2514	1.0252	6203.92	eh-domain containing protein 1 (testilin) (hpast1). [swissprot;acc:q9h4m9]	6360.25
2515		6203.94	eh-domain containing protein 3. [swissprot;acc:q9nzn3]
2516	1.02519	6203.95	eh-domain containing protein 4 (eh domain-containing protein fksg7) (hepatocellular carcinoma-associated protein 10/11). [swissprot;acc:q9h223]	6360.24
2517		6203.96	eh-domain containing protein 2. [swissprot;acc:q9nzn4]
2518	1.02516	6204.15	sin3 associated polypeptide p18 (2hor0202). [swissprot;acc:o00422]	6360.27
2519	1.02511	5964.17	adenine phosphoribosyltransferase (ec 2.4.2.7) (aprt). [swissprot;acc:p07741]	6113.96
2520			estradiol 17 beta-dehydrogenase 1 (ec 1.1.1.62) (17-beta-hsd 1) (placental 17-beta-hydroxysteroid dehydrogenase) (20 alpha- hydroxysteroid dehydrogenase) (20-alpha-hsd) (e2dh). [swissprot;acc:p14061]
2521			17 beta-hydroxysteroid dehydrogenase. [sptrembl;acc:q13034]
2522			retinol dehydrogenase 8 (all-trans); photoreceptor outer segment all-trans retinol dehydrogenase. [refseq;acc:nm_015725]
2523	1.02508	3803.04	dna-directed rna polymerase i 40 kda polypeptide (ec 2.7.7.6) (rpa40) (rpa39). [swissprot;acc:o15160]	3710.01
2524	1.02505	8695.15	myo-inositol 1-phosphate synthase a1. [refseq;acc:nm_016368]	8912.98
2525			arsenical pump-driving atpase (ec 3.6.3.16) (arsenite-translocating atpase) (arsenical resistance atpase) (arsenite-transporting atpase) (arsa) (asna-i). [swissprot;acc:o43681]
2526			ubiquitin-like protein gdx (ubiquitin-like protein 4). [swissprot;acc:p11441]
2527			large proline-rich protein bat3 (hla-b-associated transcript 3) (g3). [swissprot;acc:p46379]
2528	1.02487	6205.14	reticulon 4 (neurite outgrowth inhibitor) (nogo protein) (foocen) (neuroendocrine-specific protein) (nsp) (neuroendocrine specific protein c homolog) (rtn-x) (reticulon 5) (my043 protein). [swissprot;acc:q9nqc3]	6359.44
2529	1.02442	6436.43	protein cgi-147. [swissprot;acc:q9y3e5]	6283
2530	1.02431	3880.5	28s ribosomal protein s9, mitochondrial precursor (mrp-s9). [swissprot;acc:p82933]	3788.42
2531	1.02428	6141.97	polymyositis/scleroderma autoantigen 2 (autoantigen pm/scl 2) (polymyositis/scleroderma autoantigen 100 kda) (pm/scl-100) (p100 polymyositis-scleroderma overlap syndrome associated autoantigen). [swissprot;acc:q01780]	6291.08
2532	1.02401	4888.72	60s ribosomal protein l15. [swissprot;acc:p39030]	5006.1
2533	1.02356	3847.84	dna-directed rna polymerase i 135 kda polypeptide (ec 2.7.7.6) (rna polymerase i subunit 2) (rpa135). [swissprot;acc:q9h9y6]	3759.28
2534	1.0235	6452.33	thyroid receptor interacting protein 12 (trip12). [swissprot;acc:q14669]	6603.94
2535			dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor (ec 2.3.1.61) (e2) (e2k). [swissprot;acc:p36957]
2536	1.02348	5932.05	sorting nexin 1. [swissprot;acc:q13596]	6071.35
2537	1.02327	6669.22	pyruvate dehydrogenase e1 component alpha subunit, testis-specific form, mitochondrial precursor (ec 1.2.4.1) (pdhe1-a type ii). [swissprot;acc:p29803]	6824.41
2538	1.02325	7121.07	estradiol 17 beta-dehydrogenase 4 (ec 1.1.1.62) (17-beta-hsd 4) (17-beta-hydroxysteroid dehydrogenase 4). [swissprot;acc:p51659]	7286.61
2539	1.02321	3805.17	ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial precursor (ec 1.10.2.2) (rieske iron-sulfur protein) (risp). [swissprot;acc:p47985]	3718.86
2540	1.0232	6672.69	pyruvate dehydrogenase e1 component alpha subunit, somatic form, mitochondrial precursor (ec 1.2.4.1) (pdhe1-a type i). [swissprot;acc:p08559]	6827.51
2541	1.02319	8542.13	tata box binding protein-associated factor, rna polymerase ii, q; taf7-like rna polymerase ii, tata box binding protein (tbp)-associated factor, 50 kd; tbp-associated factor, rna polymerase ii, q. [refseq;acc:nm_024885]	8740.23
2542	1.02302	4708.98	osteoclast stimulating factor 1. [swissprot;acc:q92882]	4817.39
2543	1.02277	8565.3	transcription initiation factor tfiid 55 kda subunit (tafii-55) (tafii55). [swissprot;acc:q15545]	8760.3
2544	1.02222	6239.69	peroxiredoxin 5, mitochondrial precursor (prx-v) (peroxisomal antioxidant enzyme) (plp) (thioredoxin peroxidase pmp20) (antioxidant enzyme b166) (aoeb166) (tpx type vi) (liver tissue 2d-page spot 71b) (alu co-repressor 1) (sbbi10). [swissprot;acc:p30044]	6378.35
2545	1.02197	8285.65	ubiquitin-conjugating enzyme e2-17 kda 3 (ec 6.3.2.19) (ubiquitin- protein ligase) (ubiquitin carrier protein) (e2(17)kb 3). [swissprot;acc:p47986]	8107.49
2546		4763.99	dna-directed rna polymerase ii 14.5 kda polypeptide (ec 2.7.7.6) (rpb9) (rpb14.5). [swissprot;acc:p36954]	4868.66
2547	1.02187	3370.46	3-phosphoinositide dependent protein kinase-1 (ec 2.7.1.37) (hpdk1). [swissprot;acc:o15530]	3444.18
2548	1.02087	4725.79	60s ribosomal protein l37 (g1.16). [swissprot;acc:p02403]	4824.4
2549			splicing factor, arginine/serine-rich 1 (pre-mrna splicing factor sf2, p33 subunit) (alternative splicing factor asf-1). [swissprot;acc:q07955]
2550			amidophosphoribosyltransferase precursor (ec 2.4.2.14) (glutamine phosphoribosylpyrophosphate amidotransferase) (atase) (gpat). [swissprot;acc:q06203]
2551			sorting nexin 17. [swissprot;acc:q15036]
2552	1.02077	4884.35	ribonuclease p protein subunit p30 (ec 3.1.26.5) (rnasep protein p30) (rnase p subunit 2). [swissprot;acc:p78346]	4985.78
2553	1.02043	3852.99	ras-related protein rab-37. [swissprot;acc:q96ax2]	3775.86
2554			ras-related protein rab-26. [swissprot;acc:q9ulw5]
2555			dna-directed rna polymerase ii 33 kda polypeptide (ec 2.7.7.6) (rpb3) (rna polymerase ii subunit 3) (rpb33) (rpb31). [swissprot;acc:p19387]
2556	1.0203	4883.73	shwachman-bodian-diamond syndrome protein (cgi-97). [swissprot;acc:q9y3a5]	4982.88
2557	1.02002	5291.65	nucleoporin-like protein rip (hiv-1 rev-binding protein) (rev interacting protein) (rev/rex activation domain-binding protein). [swissprot;acc:p52594]	5187.78
2558			intersectin 1 (sh3 domain-containing protein 1a) (sh3p17). [swissprot;acc:q15811]
2559			pram-1 protein; pml-rara target gene encoding an adaptor molecule-1. [refseq;acc:nm_032152]
2560			intersectin 2 (sh3 domain-containing protein 1b) (sh3p18) (sh3p18-like wasp associated protein). [swissprot;acc:q9nzm3]
2561			hiv-1 rev binding protein-like; rev/rex activation domain binding protein-related. [refseq;acc:nm_006076]
2562			cgthba protein (-14 gene protein). [swissprot;acc:q12980]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.