MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2727 to 2776 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	red	green	network_comparison
2727	no value	atp-dependent dna helicase ii, 70 kda subunit (lupus ku autoantigen protein p70) (ku70) (70 kda subunit of ku antigen) (thyroid-lupus autoantigen) (tlaa) (ctc box binding factor 75 kda subunit) (ctcbf) (ctc75). [swissprot;acc:p12956]	221.001	220.927	1.00033
2728	XRCC5	atp-dependent dna helicase ii, 80 kda subunit (lupus ku autoantigen protein p86) (ku86) (ku80) (86 kda subunit of ku antigen) (thyroid- lupus autoantigen) (tlaa) (ctc box binding factor 85 kda subunit) (ctcbf) (ctc85) (nuclear factor iv) (dna-repair protein xrcc5). [swissprot;acc:p13010]
2729	OTUB1	ubiquitin-specific protease otubain 1. [refseq;acc:nm_017670]	202.123	202.06	1.00031
2730	C1QBP	complement component 1, q subcomponent binding protein, mitochondrial precursor (glycoprotein gc1qbp) (gc1q-r protein) (hyaluronan-binding protein 1) (p32) (p33). [swissprot;acc:q07021]	212.922	212.985	1.0003
2731	SIRT1	sirtuin 1; sir2-like 1; sirtuin type 1; sir2alpha; sirtuin silent mating type information regulation 2 homolog 1 (s. cerevisiae). [refseq;acc:nm_012238]
2732	GCN5L2	general control of amino acid synthesis protein 5-like 2 (ec 2.3.1.-) (histone acetyltransferase gcn5) (hsgcn5). [swissprot;acc:q92830]	202.233	202.175	1.00029
2733	PCAF	p300/cbp-associated factor (ec 2.3.1.-) (p/caf) (histone acetylase pcaf). [swissprot;acc:q92831]	202.229	202.172	1.00028
2734	no value	ischemia/reperfusion inducible protein. [refseq;acc:nm_024640]	219.95	220.007	1.00026
2735	HSP90AA2	heat shock protein hsp 90-alpha (hsp 86). [swissprot;acc:p07900]	220.943	220.887	1.00025
2736	no value	transcription factor mafg (v-maf musculoaponeurotic fibrosarcoma oncogene homolog g) (hmaf). [swissprot;acc:o15525]	198.278	198.321	1.00022
2737	MAFF	transcription factor maff (v-maf musculoaponeurotic fibrosarcoma oncogene homolog f) (u-maf). [swissprot;acc:q9ulx9]
2738	no value	transcription factor mafk (erythroid transcription factor nf-e2 p18 subunit). [swissprot;acc:o60675]
2739	CHL1	cell adhesion molecule with homology to l1cam precursor; neural cell adhesion molecule; cell adhesion molecule l1-like; l1 cell adhesion molecule 2. [refseq;acc:nm_006614]
2740	no value	neural cell adhesion molecule l1 precursor (n-cam l1) (cd171 antigen). [swissprot;acc:p32004]
2741	TAF9	transcription initiation factor tfiid 31 kda subunit (tafii-31) (tafii-32) (tafii32). [swissprot;acc:q16594]
2742	NFE2L1	nuclear factor erythroid 2 related factor 1 (nf-e2 related factor 1) (nfe2-related factor 1) (nuclear factor, erythroid derived 2, like 1) (transcription factor 11) (transcription factor hbz17) (transcription factor lcr-f1) (locus control region-factor 1). [swissprot;acc:q14494]
2743	NFE2L3	nuclear factor (erythroid-derived 2)-like 3; nf-e2-related factor 3. [refseq;acc:nm_004289]
2744	TADA3L	transcriptional adaptor 3-like isoform a. [refseq;acc:nm_006354]	201.476	201.514	1.00019
2745	FRG1	frg1 protein (fshd region gene 1 protein). [swissprot;acc:q14331]
2746	TADA2L	transcriptional adapter 2-like (ada2-like protein) (kl04p). [swissprot;acc:o75478]
2747	BRD7	bromodomain containing 7; bromodomain protein; bromodomain-containing 7. [refseq;acc:nm_013263]	201.477		1.00018
2748	SGTA	small glutamine-rich tetratricopeptide repeat-containing protein (vpu-binding protein) (ubp). [swissprot;acc:o43765]	189.563	189.531	1.00017
2749	HGS	hepatocyte growth factor-regulated tyrosine kinase substrate; human growth factor-regulated tyrosine kinase substrate. [refseq;acc:nm_004712]	190.522	190.496	1.00014
2750	COG7	conserved oligomeric golgi complex component 7. [swissprot;acc:p83436]
2751	PSMA1	proteasome subunit alpha type 1 (ec 3.4.25.1) (proteasome component c2) (macropain subunit c2) (multicatalytic endopeptidase complex subunit c2) (proteasome nu chain) (30 kda prosomal protein) (pros-30). [swissprot;acc:p25786]	215.338	215.312	1.00012
2752	TP53RK	p53-related protein kinase (ec 2.7.1.-) (nori-2). [swissprot;acc:q96s44]	221.7	221.716	1.00007
2753	AGXT	serine--pyruvate aminotransferase (ec 2.6.1.51) (spt) (alanine-- glyoxylate aminotransferase) (ec 2.6.1.44) (agt). [swissprot;acc:p21549]	208.859	208.846	1.00006
2754	MTHFS	5-formyltetrahydrofolate cyclo-ligase (ec 6.3.3.2) (5,10-methenyl- tetrahydrofolate synthetase) (methenyl-thf synthetase) (mthfs). [swissprot;acc:p49914]	210.638	210.642	1.00002
2755	DHPS	deoxyhypusine synthase (ec 2.5.1.46) (dhs). [swissprot;acc:p49366]	212.403	212.401	1.00001
2756	no value	3 beta-hydroxysteroid dehydrogenase (fragments). [sptrembl;acc:q9udk8]	0.00001	0.00001	1
2757	NAP1L1	nucleosome assembly protein 1-like 1 (nap-1 related protein). [swissprot;acc:p55209]
2758	NAP1L2	nucleosome assembly protein 1-like 2 (brain-specific protein, x- linked). [swissprot;acc:q9ulw6]
2759	RXRA	retinoic acid receptor rxr-alpha. [swissprot;acc:p19793]
2760	TAL2	t-cell acute lymphocytic leukemia-2 protein (tal-2 protein). [swissprot;acc:q16559]
2761	GNB1L	guanine nucleotide-binding protein beta subunit-like protein 1 (g protein beta-subunit like protein 1) (wd40 repeat containing protein deleted in vcfs) (wdvcf protein) (fksg1 protein) (dgcrk3). [swissprot;acc:q9byb4]
2762	DRG1	developmentally regulated gtp-binding protein 1 (drg 1). [swissprot;acc:q9y295]
2763	PCGF3	ring finger protein 3. [refseq;acc:nm_006315]
2764	RAB11B	ras-related protein rab-11b (gtp-binding protein ypt3). [swissprot;acc:q15907]
2765	no value	histone h2a.e (h2a/e). [swissprot;acc:q99878]
2766	SS18L1	ss18-like protein 1 (syt homolog-1). [swissprot;acc:o75177]
2767	no value	histone h2a.c/d/i/n/p (h2a.1) (h2a/c) (h2a/d) (h2a/i) (h2a/n) (h2a/p) (h2a.1b). [swissprot;acc:p02261]
2768	HIST2H2AB	histone h2a.x (h2a/x). [swissprot;acc:p16104]
2769	HIST2H2AC	histone h2a.q (h2a/q) (h2a-gl101) (fragment). [swissprot;acc:q16777]
2770	NIPSNAP1	nipsnap1 protein. [swissprot;acc:q9bpw8]
2771	TBX1	t-box transcription factor tbx1 (t-box protein 1) (testis-specific t-box protein). [swissprot;acc:o43435]
2772	NUDT14	uridine diphosphate glucose pyrophosphatase. [refseq;acc:nm_177533]
2773	BMP8A	bone morphogenetic protein 8 precursor (bmp-8) (osteogenic protein 2) (op-2). [swissprot;acc:p34820]
2774	C3orf37	dc12 protein. [refseq;acc:nm_020187]
2775	JRKL	jerky protein homolog like (hhmjg). [swissprot;acc:q9y4a0]
2776	BCOR	bcl-6 interacting corepressor isoform 1. [refseq;acc:nm_017745]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.