Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Rank Gene Hugo description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 601 to 650 of 6456 in total
Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1
Rank
Hugo
description
Network Comparison Type
red
green
network_comparison
301 ALG1 beta-1,4 mannosyltransferase. [refseq;acc:nm_019109] Divided 150.982 166.372 1.10193
MAGED4 melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801] Subtracted 88.2482 110.265 22.0168
302 MAGEE2 hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]
RPL26 60s ribosomal protein l26. [swissprot;acc:q02877] Divided 242.326 267.008 1.10185
303 no value melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357] Subtracted 88.2482 110.265 22.0168
RPL35 60s ribosomal protein l35. [swissprot;acc:p42766] Divided 242.333 266.999 1.10179
304 no value 40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174] 242.339 266.986 1.1017
MAGEA11 melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364] Subtracted 88.2482 110.265 22.0168
305 MAGEA2B melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]
MRPL2 mitochondrial ribosomal protein l2. [refseq;acc:nm_015950] Divided 242.339 266.986 1.1017
306 no value 60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914] 242.153 266.673 1.10126
hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932] Subtracted 88.2482 110.265 22.0168
307 MAGEA6 melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]
SRR serine racemase (ec 5.1.1.-). [swissprot;acc:q9gzt4] Divided 242.153 266.673 1.10126
308 NDN necdin. [swissprot;acc:q99608] Subtracted 88.2482 110.265 22.0168
RPL34 60s ribosomal protein l34. [swissprot;acc:p49207] Divided 242.153 266.673 1.10126
309 MAGED1 melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3] Subtracted 88.2482 110.265 22.0168
SEC61A2 protein transport protein sec61 alpha subunit isoform 2 (sec61 alpha- 2). [swissprot;acc:q9y2r3] Divided 242.153 266.673 1.10126
310 MAGEF1 melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2] Subtracted 88.2482 110.265 22.0168
SEC61A1 protein transport protein sec61 alpha subunit isoform 1 (sec61 alpha- 1). [swissprot;acc:p38378] Divided 242.153 266.673 1.10126
311 EIF1B protein translation factor sui1 homolog gc20. [swissprot;acc:o60739] 242.627 267.151 1.10108
MAGEB6B melanoma antigen, family b, 6. [refseq;acc:nm_173523] Subtracted 88.2482 110.265 22.0168
312 no value melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]
RPL3L 60s ribosomal protein l3-like. [swissprot;acc:q92901] Divided 242.195 266.663 1.10103
313 MAGEA9 melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362] Subtracted 88.2482 110.265 22.0168
RRM2B ribonucleotide reductase m2 b (tp53 inducible); p53-inducible ribonucleotide reductase small subunit 2 homolog. [refseq;acc:nm_015713] Divided 232.473 211.207 1.10069
314 MAGEA8 melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361] Subtracted 88.2482 110.265 22.0168
METAP1 methionine aminopeptidase 1 (ec 3.4.11.18) (metap 1) (map 1) (peptidase m 1). [swissprot;acc:p53582] Divided 244.126 268.604 1.10027
315 MAGEC1 melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732] Subtracted 88.2482 110.265 22.0168
METAP2 methionine aminopeptidase 2 (ec 3.4.11.18) (metap 2) (peptidase m 2) (initiation factor 2 associated 67 kda glycoprotein) (p67) (p67eif2). [swissprot;acc:p50579] Divided 244.126 268.604 1.10027
316 EIF1 protein translation factor sui1 homolog (sui1iso1). [swissprot;acc:p41567] 242.694 267.017 1.10022
MAGEA4 melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365] Subtracted 88.2482 110.265 22.0168
317 no value melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]
splicing factor 3b subunit 3 (spliceosome associated protein 130) (sap 130) (sf3b130) (pre-mrna splicing factor sf3b 130 kda subunit). [swissprot;acc:q15393] Divided 224.445 204.044 1.09998
318 MAGEA10 melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363] Subtracted 88.2482 110.265 22.0168
MRPL3 mitochondrial 60s ribosomal protein l3 (l3mt). [swissprot;acc:p09001] Divided 242.011 266.18 1.09987
319 MAGEB4 melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366] Subtracted 88.2482 110.265 22.0168
RPL19 60s ribosomal protein l19. [swissprot;acc:p14118] Divided 240.73 264.729 1.09969
320 CDH1 epithelial-cadherin precursor (e-cadherin) (uvomorulin) (cadherin-1) (cam 120/80). [swissprot;acc:p12830] 241.892 265.96 1.0995
MAGED2 melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1] Subtracted 88.2482 110.265 22.0168
321 no value c367g8.3 (novel protein similar to rpl23a (60s ribosomal protein l23a)) (60s ribosomal protein l23a like). [sptrembl;acc:q9br02] Divided 241.892 265.959 1.09949
TRO trophinin. [swissprot;acc:q12816] Subtracted 88.2482 110.265 22.0168
322 DNASE2B deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233] Divided 86.7483 78.8995 1.09948
RRM2 ribonucleoside-diphosphate reductase m2 chain (ec 1.17.4.1) (ribonucleotide reductase small chain). [swissprot;acc:p31350] Subtracted 231.969 210.064 21.905
323 no value 60s ribosomal protein l23a. [swissprot;acc:p29316] Divided 241.884 265.945 1.09947
RPS14 40s ribosomal protein s14 (pro2640). [swissprot;acc:p06366] Subtracted 242.238 264.11 21.872
324 no value 40s ribosomal protein s18 (ke-3) (ke3). [swissprot;acc:p25232]
RPS23 40s ribosomal protein s23. [swissprot;acc:p39028] Divided 243.944 268.195 1.09941
325 MRPL13 60s ribosomal protein l13, mitochondrial (l13mt). [swissprot;acc:q9byd1] Subtracted 241.828 263.62 21.792
MRPS12 28s ribosomal protein s12, mitochondrial precursor (mpr-s12) (mt- rps12). [swissprot;acc:o15235] Divided 243.944 268.195 1.09941

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/