MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Gene	Network Comparison Type	Value Type	red	Rank	green	description	Interaction Map	Filtered	network_comparison

Results: HTML CSV LaTeX

Showing element 2063 to 2112 of 3228 in total

Network Comparison Type  : Divided
Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

red	Rank	green	description	network_comparison
5894.47	1268	6383.73	sfrs protein kinase 1; sr protein kinase 1. [refseq;acc:nm_003137]	1.083
	1269		xap-5 protein (hxc-26 protein). [swissprot;acc:q14320]
5894.75	302	7073.65	pallidin; pallid (mouse) homolog, pallidin. [refseq;acc:nm_012388]	1.19999
5896.51	2179	6196.59	elav-like protein 4 (paraneoplastic encephalomyelitis antigen hud) (hu-antigen d). [swissprot;acc:p26378]	1.05089
5900.25	2180	6200.24	elav-like protein 2 (hu-antigen b) (hub) (elav-like neuronal protein 1) (nervous system-specific rna binding protein hel-n1). [swissprot;acc:q12926]	1.05084
5902.26	2237	6181.21	cathepsin l2 precursor (ec 3.4.22.43) (cathepsin v) (cathepsin u). [swissprot;acc:o60911]	1.04726
5902.27	2236		sodium/potassium-transporting atpase alpha-1 chain precursor (ec 3.6.3.9) (sodium pump 1) (na+/k+ atpase 1). [swissprot;acc:p05023]
	2238		cathepsin l precursor (ec 3.4.22.15) (major excreted protein) (mep). [swissprot;acc:p07711]
	2239		sodium/potassium-transporting atpase alpha-3 chain (ec 3.6.3.9) (sodium pump 3) (na+/k+ atpase 3) (alpha(iii)). [swissprot;acc:p13637]
	2240		sodium/potassium-transporting atpase alpha-2 chain precursor (ec 3.6.3.9) (sodium pump 2) (na+/k+ atpase 2). [swissprot;acc:p50993]
5903.18	886	6506.32	upstream binding protein 1 (lbp-1a). [refseq;acc:nm_014517]	1.10217
	887		transcription factor cp2; transcription factor cp2, alpha globin. [refseq;acc:nm_005653]
	888		lbp-9. [refseq;acc:nm_014553]
	889		splicing factor, arginine/serine-rich 3 (pre-mrna splicing factor srp20) (x16 protein). [swissprot;acc:p23152]
5910.06	1473	6355.08	calmegin precursor. [swissprot;acc:o14967]	1.0753
	1474		calnexin precursor (major histocompatibility complex class i antigen-binding protein p88) (p90) (ip90). [swissprot;acc:p27824]
	1475		soluble liver antigen/liver pancreas antigen. [refseq;acc:nm_153825]
	1476		rna (guanine-7-) methyltransferase. [refseq;acc:nm_003799]
5910.12	2214	6199.28	chromosome 11 open reading frame2; chromosome 11 open reading frame2. [refseq;acc:nm_013265]	1.04893
	2215		kinesin-like protein kif13a (kinesin-like protein rbkin). [swissprot;acc:q9h1h9]
	2216		conserved oligomeric golgi complex component 2 (low density lipoprotein receptor defect c-complementing protein). [swissprot;acc:q14746]
	2217		kinesin-like protein kif13b (kinesin-like protein gakin). [swissprot;acc:q9nqt8]
5910.54	1112	6440.58	putative phosphoglycerate mutase 3 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13). [swissprot;acc:q8n0y7]	1.08968
	1113		phosphoglycerate mutase 1 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13) (phosphoglycerate mutase isozyme b) (pgam-b) (bpg-dependent pgam 1). [swissprot;acc:p18669]
	1114		phosphoglycerate mutase 2 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13) (phosphoglycerate mutase isozyme m) (pgam-m) (bpg-dependent pgam 2) (muscle-specific phosphoglycerate mutase). [swissprot;acc:p15259]
5912.84	881	6517.69	adp-ribosylation factor-like protein 7 (adp-ribosylation factor-like protein lak). [swissprot;acc:p56559]	1.10229
	882		vacuolar atp synthase subunit d (ec 3.6.3.14) (v-atpase d subunit) (vacuolar proton pump d subunit) (v-atpase ac39 subunit) (v-atpase 40 kda accessory protein) (p39) (32 kda accessory protein). [swissprot;acc:p12953]
	883		adp-ribosylation factor-like protein 4. [swissprot;acc:p40617]
5913.73	1208	6423.98	meiotic recombination protein dmc1/lim15 homolog. [swissprot;acc:q14565]	1.08628
5915.42	1120	6443.77	heat shock factor binding protein 1. [swissprot;acc:o75506]	1.08932
5916.05	1529	6350.53	dna fragmentation factor 40 kda subunit (ec 3.-.-.-) (dff-40) (caspase-activated deoxyribonuclease) (caspase-activated dnase) (cad) (caspase-activated nuclease) (cpan). [swissprot;acc:o76075]	1.07344
	1530		adamts-9 precursor (ec 3.4.24.-) (a disintegrin and metalloproteinase with thrombospondin motifs 9) (adam-ts 9) (adam-ts9). [swissprot;acc:q9p2n4]
	1531		dna fragmentation factor alpha subunit (dna fragmentation factor 45 kda subunit) (dff-45) (inhibitor of cad) (icad). [swissprot;acc:o00273]
	1532		ankyrin 3 (ank-3) (ankyrin g). [swissprot;acc:q12955]
	1533		ankyrin 2 (brain ankyrin) (ankyrin b) (ankyrin, nonerythroid). [swissprot;acc:q01484]
	1534		adp-ribosylation factor-like protein 3. [swissprot;acc:p36405]
	1535		unc-119 protein homolog (retinal protein 4) (hrg4). [swissprot;acc:q13432]
	1536		26s proteasome non-atpase regulatory subunit 8 (26s proteasome regulatory subunit s14) (p31). [swissprot;acc:p48556]
5916.13	1710	6321.77	camp-dependent protein kinase type ii-alpha regulatory chain. [swissprot;acc:p13861]	1.06857
5917.22	1711	6322.72	protein kinase pkx1 (ec 2.7.1.-). [swissprot;acc:p51817]	1.06853
5917.23	1712	6322.73	camp-dependent protein kinase, gamma-catalytic subunit (ec 2.7.1.37) (pka c-gamma). [swissprot;acc:p22612]
	1713		camp-dependent protein kinase, beta-catalytic subunit (ec 2.7.1.37) (pka c-beta). [swissprot;acc:p22694]
	1714		camp-dependent protein kinase, alpha-catalytic subunit (ec 2.7.1.37) (pka c-alpha). [swissprot;acc:p17612]
5918.48	1715	6323.83	camp-dependent protein kinase type ii-beta regulatory chain. [swissprot;acc:p31323]	1.06849
5920.55	1628	6337.28	glycine cleavage system h protein, mitochondrial precursor. [swissprot;acc:p23434]	1.07039
5923.66	1576	6349.04	mitochondrial ribosomal protein l30 isoform a. [refseq;acc:nm_145212]	1.07181
	1577		26s protease regulatory subunit s10b (proteasome subunit p42) (p44) (conserved atpase domain protein 44) (cadp44). [swissprot;acc:q92524]
5925.65	1736	6326.43	twinkle; likely ortholog of mouse t7 gp4-like protein with intramitochondrial nucleoid localization. [refseq;acc:nm_021830]	1.06763
	1737		rabaptin, rab gtpase binding effector protein 1; rabaptin-5; neurocrescin. [refseq;acc:nm_004703]
5926.76	1527	6362.33	26s protease regulatory subunit 6a (tat-binding protein 1) (tbp-1) (proteasome subunit p50). [swissprot;acc:p17980]	1.07349

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.