Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison

Results: HTML CSV LaTeX

Showing element 558 to 607 of 12912 in total

Network Comparison Type	Divided
Interaction Map	High confidence
Filtered	1

Rank	description	Value Type	red	green	network_comparison	
140	filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [source:refseq;acc:nm_001457]	Rooted	55.6161	66.7332	1.19989	
140	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [source:refseq;acc:nm_173193]	Measured	2760.28	2100.27	1.31425	
140	ras-related gtp binding a; ras-related gtp-binding protein. [source:refseq;acc:nm_006570]	Ranked	59	49	1.20408	
141	g2/mitotic-specific cyclin b1. [source:swissprot;acc:p14635]	Squared	81520.8	56188.5	1.45084	
141	ras-related gtp binding c; rag c protein. [source:refseq;acc:nm_022157]	Ranked	59	49	1.20408	
141	rev1-like; rev1 protein; rev1 (yeast homolog)- like. [source:refseq;acc:nm_016316]	Rooted	55.6161	66.7332	1.19989	
141	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [source:swissprot;acc:p43330]	Measured	4405.4	5782.08	1.3125	
142	cell division control protein 2 homolog (ec 2.7.1.-) (p34 protein kinase) (cyclin-dependent kinase 1) (cdk1). [source:swissprot;acc:p06493]	Squared	81478.9	56175.2	1.45044	
142	metalloprotease 1; metalloprotease 1 (pitrilysin family). [source:refseq;acc:nm_014889]	Measured	9276.47	7090.37	1.30832	
142	protein arginine n-methyltransferase 1 (ec 2.1.1.-) (interferon receptor 1-bound protein 4). [source:swissprot;acc:q99873]	Rooted	55.6161	66.7332	1.19989	
142	ras-related gtp binding b short isoform; gtp-binding protein ragb. [source:refseq;acc:nm_006064]	Ranked	59	49	1.20408	
143	anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [source:refseq;acc:nm_018685]	Ranked	59	49	1.20408	
143	beta-1,4 mannosyltransferase. [source:refseq;acc:nm_019109]	Measured	9275.1	7089.65	1.30826	
143	protein arginine n-methyltransferase 4 (ec 2.1.1.-). [source:swissprot;acc:q9nr22]	Rooted	55.6161	66.7332	1.19989	
143	protein phosphatase 1, regulatory (inhibitor) subunit 13b; apoptosis-stimulating protein of p53, 1. [source:refseq;acc:nm_015316]	Squared	124319	86848.2	1.43145	
144	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [source:refseq;acc:nm_014592]	Ranked	265.686	319.651	1.20312	
144	sad1/unc-84 protein-like 1. [source:swissprot;acc:o94901]	Measured	3349.9	4362.61	1.30231	
144	tumor suppressor p53-binding protein 2 (p53-binding protein 2) (53bp2) (bcl2-binding protein) (bbp). [source:swissprot;acc:q13625]	Squared	123324	86277.9	1.42938	
144	u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [source:swissprot;acc:p08621]	Rooted	55.6161	66.7332	1.19989	
145	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [source:swissprot;acc:p21333]	Rooted	55.6161	66.7332	1.19989	
145	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [source:refseq;acc:nm_006333]	Squared	310840	442993	1.42515	
145	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [source:refseq;acc:nm_147183]	Ranked	265.639	319.546	1.20293	
145	ubiquitin activating enzyme e1-like protein. [source:refseq;acc:nm_006395]	Measured	16771.5	12889.1	1.30122	
146	associated molecule with the sh3 domain of stam (amsh) like protein. [source:refseq;acc:nm_020799]	Measured	11068	8508.5	1.30082	
146	huntingtin interacting protein c. [source:refseq;acc:nm_012272]	Rooted	55.0737	66.0298	1.19894	
146	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [source:refseq;acc:nm_173193]	Ranked	265.632	319.531	1.20291	
146	ras-related gtp binding a; ras-related gtp-binding protein. [source:refseq;acc:nm_006570]	Squared	103496	146848	1.41888	
147	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [source:refseq;acc:nm_138457]	Rooted	42.0574	50.4237	1.19893	
147	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [source:refseq;acc:nm_006333]	Ranked	50.7983	42.3003	1.2009	
147	putative breast adenocarcinoma marker (32kd). [source:refseq;acc:nm_014453]	Measured	11068	8508.5	1.30082	
147	ras-related gtp binding c; rag c protein. [source:refseq;acc:nm_022157]	Squared	103496	146848	1.41888	
148	associated molecule with the sh3 domain of stam. [source:refseq;acc:nm_006463]	Measured	11068	8508.5	1.30082	
148	forkhead box protein p1 (hspc215). [source:swissprot;acc:q9h334]	Rooted	42.0577	50.424	1.19892	
148	ras-related gtp binding b short isoform; gtp-binding protein ragb. [source:refseq;acc:nm_006064]	Squared	103496	146848	1.41888	
148	sad1/unc-84 protein-like 1. [source:swissprot;acc:o94901]	Ranked	296.677	247.559	1.19841	
149	anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [source:refseq;acc:nm_018685]	Squared	103496	146848	1.41888	
149	atlastin; guanylate-binding protein 3. [source:refseq;acc:nm_015915]	Ranked	142	170	1.19718	
149	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [source:swissprot;acc:q9bzs1]	Rooted	42.0684	50.4323	1.19882	
149	neuroendocrine differentiation factor; comparative gene identification transcript 149. [source:refseq;acc:nm_016079]	Measured	11068	8508.5	1.30082	
150	myosin vb (myosin 5b) (fragment). [source:swissprot;acc:q9ulv0]	Ranked	55	46	1.19565	
150	pre-mrna cleavage complex ii protein clp1. [source:swissprot;acc:q92989]	Squared	121200	85473.4	1.41799	
150	protein hspc134 (protein cda04). [source:swissprot;acc:q9by43]	Measured	11068	8508.5	1.30082	
150	serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [source:swissprot;acc:p05323]	Rooted	63.5827	53.0856	1.19774	
151	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [source:swissprot;acc:q9nrg0]	Rooted	38.8223	46.4975	1.1977	
151	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [source:refseq;acc:nm_021233]	Squared	250303	354894	1.41786	
151	myosin vc (myosin 5c). [source:swissprot;acc:q9nqx4]	Ranked	55	46	1.19565	
151	sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [source:refseq;acc:nm_005489]	Measured	4578.09	5939.91	1.29746	
152	luc7-like 2; cgi-74 protein; cgi-59 protein. [source:refseq;acc:nm_016019]	Rooted	55.2859	65.9288	1.19251	
152	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [source:refseq;acc:nm_030801]	Measured	23693.7	18263	1.29736	
152	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [source:swissprot;acc:q9y4i1]	Ranked	55	46	1.19565	

Legend:
- Rank is the rank after comparing the two networks
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.

- http://analysis.yellowcouch.org/