MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 875 to 924 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	green	red	network_comparison
438	block of proliferation 1. [swissprot;acc:q14137]	Subtracted	234.433	250.794	16.361
	n-terminal acetyltransferase complex ard1 subunit homolog (ec 2.3.1.-). [swissprot;acc:p41227]	Divided	216.674	233.723	1.07869
439	40s ribosomal protein s9. [swissprot;acc:p46781]		257.784	238.986	1.07866
	pescadillo homolog 1. [swissprot;acc:o00541]	Subtracted	234.941	251.297	16.356
440	40s ribosomal protein s26. [swissprot;acc:p02383]		226.578	210.224	16.354
	highly expressed in cancer, rich in leucine heptad repeats. [refseq;acc:nm_006101]	Divided	249.983	231.802	1.07843
441	grb2-related adaptor protein. [swissprot;acc:q13588]		207.222	223.457	1.07835
	mitochondrial import inner membrane translocase subunit tim22. [swissprot;acc:q9y584]	Subtracted	226.578	210.225	16.353
442	atp synthase mitochondrial f1 complex assembly factor 2. [refseq;acc:nm_145691]
	e2a-pbx1-associated protein; putative 47 kda protein. [refseq;acc:nm_020140]	Divided	207.55	223.802	1.0783
443	neuron navigator 2 isoform l; retinoic acid inducible in neuroblastoma; pore membrane and/or filament interacting like protein 2; helicase helad1. [refseq;acc:nm_145117]		207.539	223.79
	ubiquinol-cytochrome c reductase complex 14 kda protein (ec 1.10.2.2) (complex iii subunit vi) (qp-c). [swissprot;acc:p14927]	Subtracted	226.578	210.225	16.353
444	neuron navigator 1; neuron navigator-1; pore membrane and/or filament interacting like protein 3. [refseq;acc:nm_020443]	Divided	207.549	223.801	1.0783
	proliferating-cell nucleolar antigen p120 (proliferation-associated nucleolar protein p120). [swissprot;acc:p46087]	Subtracted	233.725	250.053	16.328
445	neuron navigator 3; pore membrane and/or filament interacting like protein 1; steerin 3. [refseq;acc:nm_014903]	Divided	207.549	223.801	1.0783
	nucleostemin; putative nucleotide binding protein, estradiol-induced. [refseq;acc:nm_014366]	Subtracted	234.563	250.858	16.295
446	growth factor receptor-bound protein 2 (grb2 adapter protein) (sh2/sh3 adapter grb2) (ash protein). [swissprot;acc:p29354]	Divided	207.785	224.049	1.07827
		Subtracted			16.264
447	serine/threonine-protein kinase nek2 (ec 2.7.1.37) (nima-related protein kinase 2) (nima-like protein kinase 1) (hspk 21). [swissprot;acc:p51955]	Divided			1.07827
		Subtracted			16.264
448	e2a-pbx1-associated protein; putative 47 kda protein. [refseq;acc:nm_020140]		207.55	223.802	16.252
	microtubule-actin crosslinking factor 1, isoform 4. [swissprot;acc:q96pk2]	Divided	246.338	228.468	1.07822
449	bullous pemphigoid antigen 1 isoforms 1/2/3/4/5/8 (230 kda bullous pemphigoid antigen) (bpa) (hemidesmosomal plaque protein) (dystonia musculorum protein) (fragment). [swissprot;acc:q03001]		246.33	228.463	1.07821
	neuron navigator 1; neuron navigator-1; pore membrane and/or filament interacting like protein 3. [refseq;acc:nm_020443]	Subtracted	207.549	223.801	16.252
450	neuron navigator 3; pore membrane and/or filament interacting like protein 1; steerin 3. [refseq;acc:nm_014903]
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	Divided	218.837	235.94	1.07815
451	neuron navigator 2 isoform l; retinoic acid inducible in neuroblastoma; pore membrane and/or filament interacting like protein 2; helicase helad1. [refseq;acc:nm_145117]	Subtracted	207.539	223.79	16.251
	polymerase (rna) iii (dna directed) (62kd). [refseq;acc:nm_006468]	Divided	257.705	239.092	1.07785
452	ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36]		207.972	224.161	1.07784
	polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195]	Subtracted	205.286	221.522	16.236
453	paxillin. [swissprot;acc:p49023]
	u2 small nuclear ribonucleoprotein a' (u2 snrnp-a'). [swissprot;acc:p09661]	Divided	207.972	224.161	1.07784
454	40s ribosomal protein s26. [swissprot;acc:p02383]		226.578	210.224	1.07779
	grb2-related adaptor protein. [swissprot;acc:q13588]	Subtracted	207.222	223.457	16.235
455	ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36]		207.972	224.161	16.189
	mitochondrial import inner membrane translocase subunit tim22. [swissprot;acc:q9y584]	Divided	226.578	210.225	1.07779
456	atp synthase mitochondrial f1 complex assembly factor 2. [refseq;acc:nm_145691]
	u2 small nuclear ribonucleoprotein a' (u2 snrnp-a'). [swissprot;acc:p09661]	Subtracted	207.972	224.161	16.189
457	ba138e2.1.2 (formin-binding protein 17 (fbp17), isoform 2). [sptrembl;acc:q96lh6]		226.764	210.578	16.186
	ubiquinol-cytochrome c reductase complex 14 kda protein (ec 1.10.2.2) (complex iii subunit vi) (qp-c). [swissprot;acc:p14927]	Divided	226.578	210.225	1.07779
458	atp-dependent rna helicase ddx18 (dead-box protein 18) (myc-regulated dead-box protein) (mrdb). [swissprot;acc:q9nvp1]	Subtracted	235.506	251.653	16.147
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	Divided	218.925	235.922	1.07764
459	bag-family molecular chaperone regulator-3 (bcl-2 binding athanogene- 3) (bag-3) (bcl-2-binding protein bis) (docking protein cair-1). [swissprot;acc:o95817]		216.737	233.529	1.07748
	nnp-1 protein (novel nuclear protein 1) (nucleolar protein nop52) (nop52) (d21s2056e). [swissprot;acc:p56182]	Subtracted	234.401	250.538	16.137
460	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]		170.42	186.52	16.1
	splicing factor 3a subunit 2 (spliceosome associated protein 62) (sap 62) (sf3a66). [swissprot;acc:q15428]	Divided	207.62	223.648	1.0772
461	krueppel-like factor 5 (intestinal-enriched krueppel-like factor) (colon krueppel-like factor) (transcription factor bteb2) (basic transcription element binding protein 2) (bte-binding protein 2) (gc box binding protein 2). [swissprot;acc:q13887]
	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]	Subtracted	170.42	186.52	16.1
462	dna-directed rna polymerases i, ii, and iii 17.1 kda polypeptide (ec 2.7.7.6) (rpb17) (rpb8) (rpabc3). [swissprot;acc:p52434]		252.708	236.662	16.046
	mki67 (fha domain) interacting nucleolar phosphoprotein; nucleolar phosphoprotein nopp34; nucleolar protein interacting with the fha domain of pki-67. [refseq;acc:nm_032390]	Divided	236.224	254.434	1.07709

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.