Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Gene Rank Value Type description green Interaction Map Network Comparison Type Filtered red network_comparison
Results: HTML CSV LaTeX Showing element 451 to 500 of 16578 in total
Value Type  : Ranked
Filtered  : 1
Rank
description
green
Interaction Map
Network Comparison Type
red
network_comparison
113 natural resistance-associated macrophage protein 2 (nramp 2) (divalent metal transporter 1) (dmt1). [swissprot;acc:p49281] 210.566 Low confidence Subtracted 224.763 14.197
serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323] 234.204 High confidence 194.372 39.832
114 28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5] 44 Low confidence 58 14
b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681] 267.265 High confidence 229.818 37.447
disks large-associated protein 1 (dap-1) (guanylate kinase-associated protein) (hgkap) (sap90/psd-95-associated protein 1) (sapap1) (psd- 95/sap90 binding protein 1). [swissprot;acc:o14490] 211.983 Low confidence Divided 197.779 1.07182
kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559] 267.246 High confidence 332.874 1.24557
115 disks large-associated protein 4 (dap-4) (sap90/psd-95-associated protein 4) (sapap4) (psd-95/sap90 binding protein 4). [swissprot;acc:q9y2h0] 211.983 Low confidence 197.779 1.07182
histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929] 240.461 High confidence Subtracted 277.546 37.085
kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688] 267.246 Divided 332.874 1.24557
mitochondrial solute carrier protein. [refseq;acc:nm_145305] 44 Low confidence Subtracted 58 14
116 guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520] 334.483 High confidence Divided 268.565 1.24545
high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339] 171.595 Subtracted 208.52 36.925
testican-3 precursor. [swissprot;acc:q9bq16] 234.389 Low confidence 220.395 13.994
vacuolar protein sorting 18 (hvps18). [swissprot;acc:q9p253] 190.791 Divided 204.161 1.07008
117 coagulation factor xiii a chain precursor (ec 2.3.2.13) (protein- glutamine gamma-glutamyltransferase a chain) (transglutaminase a chain). [swissprot;acc:p00488] 211.713 226.395 1.06935
high-mobility group 20a. [refseq;acc:nm_018200] 171.778 High confidence Subtracted 208.588 36.81
neuralized-like. [refseq;acc:nm_004210] 266.948 Divided 332.326 1.24491
striated muscle activator of rho-dependent signaling. [refseq;acc:nm_139166] 211.529 Low confidence Subtracted 225.495 13.966
118 nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09] 228.934 High confidence Divided 284.753 1.24382
odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260] 237.79 Subtracted 274.027 36.237
protein-glutamine gamma-glutamyltransferase k (ec 2.3.2.13) (transglutaminase k) (tgase k) (tgk) (tg(k)) (transglutaminase 1) (epidermal tgase). [swissprot;acc:p22735] 211.713 Low confidence Divided 226.395 1.06935
testican-1 precursor (spock protein). [swissprot;acc:q08629] 234.111 Subtracted 220.254 13.857
119 adiponectin receptor 2. [refseq;acc:nm_024551] 246.371 High confidence 281.582 35.211
nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181] 259.004 Divided 318.982 1.23157
natural resistance-associated macrophage protein 1 (nramp 1). [swissprot;acc:p49279] 211.107 Low confidence 225.666 1.06897
testican-2 precursor. [swissprot;acc:q92563] 234.047 Subtracted 220.222 13.825
120 nanos (fragment). [sptrembl;acc:q8wy41] 217.479 203.66 13.819
nucleolysin tia-1 (rna-binding protein tia-1) (p40-tia-1) [contains: p15-tia-1]. [swissprot;acc:p31483] 192.715 High confidence 227.199 34.484
potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281] 327.709 Divided 269.278 1.21699
segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640] 189.965 Low confidence 203.016 1.0687
121 cystathionine gamma-lyase (ec 4.4.1.1) (gamma-cystathionase). [swissprot;acc:p32929] 327.655 High confidence 269.254 1.2169
nucleolysin tiar (tia-1 related protein). [swissprot;acc:q01085] 192.823 Subtracted 227.202 34.379
segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641] 189.985 Low confidence Divided 203.007 1.06854
vacuolar protein sorting 33a (hvps33a). [swissprot;acc:q96ax1] 190.189 Subtracted 203.914 13.725
122 cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653] 234.187 High confidence 199.949 34.238
nanos (fragment). [sptrembl;acc:q8wy41] 217.479 Low confidence Divided 203.66 1.06785
potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980] 327.642 High confidence 269.248 1.21688
vacuolar protein sorting 18 (hvps18). [swissprot;acc:q9p253] 190.791 Low confidence Subtracted 204.161 13.37
123 potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979] 327.601 High confidence Divided 269.23 1.21681
segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997] 190.094 Low confidence 202.96 1.06768
small nuclear ribonucleoprotein sm d1 (snrnp core protein d1) (sm-d1) (sm-d autoantigen). [swissprot;acc:p13641] 193.056 High confidence Subtracted 227.032 33.976
striatin. [swissprot;acc:o43815] 200.796 Low confidence 214.085 13.289
124 daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959] 206.997 220.268 13.271
high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339] 171.595 High confidence Divided 208.52 1.21519
natural resistance-associated macrophage protein 2 (nramp 2) (divalent metal transporter 1) (dmt1). [swissprot;acc:p49281] 210.566 Low confidence 224.763 1.06742
presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810] 252.234 High confidence Subtracted 285.684 33.45
125 b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681] 227.616 Low confidence Divided 213.243 1.0674
high-mobility group 20a. [refseq;acc:nm_018200] 171.778 High confidence 208.588 1.21429
prominin-like protein 1 precursor (antigen ac133) (cd133 antigen). [swissprot;acc:o43490] 206.997 Low confidence Subtracted 220.268 13.271
s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991] 252.234 High confidence 285.684 33.45

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/