Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Gene Rank Network Comparison Type Value Type description green Interaction Map red Filtered network_comparison
Results: HTML CSV LaTeX Showing element 451 to 500 of 25824 in total
Interaction Map  : High confidence
Filtered  : 1
Rank
Network Comparison Type
Value Type
description
green
red
network_comparison
57 Divided Squared melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364] 129762 219048 1.68808
Rooted potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980] 28.9554 41.6879 1.43973
Subtracted Measured ras-related gtp binding c; rag c protein. [refseq;acc:nm_022157] 24908.5 20911 3997.5
Ranked myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7] 245.247 185.678 59.569
Squared homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056] 242989 173408 69581
Rooted melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358] 120.823 137.446 16.623
58 Divided Measured kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559] 2664.55 1631.67 1.63302
Ranked guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150] 336.191 266.863 1.25979
Squared melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356] 129762 219048 1.68808
Rooted potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979] 28.9696 41.6969 1.43933
Subtracted Measured ras-related gtp binding b short isoform; gtp-binding protein ragb. [refseq;acc:nm_006064] 24908.5 20911 3997.5
Ranked glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217] 245.247 185.678 59.569
Squared retinal short-chain dehydrogenase/reductase 3. [refseq;acc:nm_016246] 242989 173408 69581
Rooted melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362] 120.823 137.446 16.623
59 Divided Measured kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688] 2664.55 1631.67 1.63302
Ranked guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798] 336.19 266.863 1.25978
Squared hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932] 129762 219048 1.68808
Rooted nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09] 52.2064 37.2205 1.40262
Subtracted Measured anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685] 24908.5 20911 3997.5
Ranked potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281] 327.709 269.278 58.431
Squared serine/threonine protein phosphatase pp1-gamma catalytic subunit (ec 3.1.3.16) (pp-1g). [swissprot;acc:p36873] 130021 199594 69573
Rooted melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361] 120.823 137.446 16.623
60 Divided Measured 1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446] 2765.82 4489.19 1.6231
Ranked guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08] 336.184 266.864 1.25976
Squared melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360] 129762 219048 1.68808
Rooted son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583] 49.8119 35.6294 1.39806
Subtracted Measured ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395] 12889.1 16771.5 3882.4
Ranked cystathionine gamma-lyase (ec 4.4.1.1) (gamma-cystathionase). [swissprot;acc:p32929] 327.655 269.254 58.401
Squared protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236] 126167 192904 66737
Rooted melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732] 120.823 137.446 16.623
61 Divided Measured glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216] 2765.82 4489.19 1.6231
Ranked guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670] 336.182 266.864 1.25975
Squared necdin. [swissprot;acc:q99608] 129762 219048 1.68808
Rooted kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592] 31.7159 43.4291 1.36932
Subtracted Measured beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121] 10307.5 6475.5 3832
Ranked potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980] 327.642 269.248 58.394
Squared type 1 protein phosphatase inhibitor. [refseq;acc:nm_025210] 126095 192779 66684
Rooted melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365] 120.823 137.446 16.623
62 Divided Measured glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737] 2765.82 4489.19 1.6231
Ranked guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151] 336.181 266.865 1.25974
Squared melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3] 129762 219048 1.68808
Rooted potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183] 31.7522 43.4519 1.36847
Subtracted Measured beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407] 10307.5 6475.5 3832
Ranked potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979] 327.601 269.23 58.371
Squared ribosome biogenesis regulatory protein homolog. [swissprot;acc:q15050] 124480 189976 65496
Rooted melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355] 120.823 137.446 16.623
63 Divided Measured myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7] 2765.82 4489.19 1.6231
Ranked guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8] 336.178 266.865 1.25973
Squared melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2] 129762 219048 1.68808
Rooted kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193] 31.7576 43.4554 1.36835

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/