Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Rank Gene Network Comparison Type Value Type description Interaction Map green red Filtered network_comparison
Results: HTML CSV LaTeX Showing element 551 to 600 of 6456 in total
Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1
Rank
Network Comparison Type
description
green
red
network_comparison
276 Divided putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37] 2579.49 3119.98 1.20953
Subtracted gbp protein isoform a. [refseq;acc:nm_017870] 1894.39 699.76 1194.63
277 Divided regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081] 2579.49 3119.98 1.20953
Subtracted mitochondrial import receptor subunit tom20 homolog (mitochondrial 20 kda outer membrane protein) (outer mitochondrial membrane receptor tom20). [swissprot;acc:q15388] 9792.49 8600.02 1192.47
278 Divided transcription factor lbx1. [swissprot;acc:p52954] 2579.49 3119.98 1.20953
Subtracted peroxisomal farnesylated protein (33 kda housekeeping protein) (peroxin 19). [swissprot;acc:p40855] 9792.49 8600.02 1192.47
279 Divided mosaic protein lgn. [swissprot;acc:p81274] 2579.49 3119.98 1.20953
Subtracted splicing factor 3b subunit 3 (spliceosome associated protein 130) (sap 130) (sf3b130) (pre-mrna splicing factor sf3b 130 kda subunit). [swissprot;acc:q15393] 5961.43 4771.21 1190.22
280 Divided regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6] 2579.49 3119.98 1.20953
Subtracted protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256] 1865.5 677.5 1188
281 Divided guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471] 2579.49 3119.98 1.20953
Subtracted microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083] 1865.5 677.5 1188
282 Divided rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736] 2579.49 3119.98 1.20953
Subtracted protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726] 1865.5 677.5 1188
283 Divided polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195] 6314.35 5221.28 1.20935
Subtracted ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485] 1865.5 677.5 1188
284 Divided paxillin. [swissprot;acc:p49023] 6314.35 5221.28 1.20935
Subtracted protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949] 1865.5 677.5 1188
285 Divided poly(a) polymerase alpha (ec 2.7.7.19) (pap) (polynucleotide adenylyltransferase alpha) (fragment). [swissprot;acc:p51003] 19296.4 23326.5 1.20885
Subtracted eukaryotic translation initiation factor 4 gamma, 3. [refseq;acc:nm_003760] 5252.6 4068.56 1184.04
286 Divided exocyst complex component sec5. [swissprot;acc:q96kp1] 19288.8 23316 1.20878
Subtracted rna-binding protein. [refseq;acc:nm_019027] 5252.17 4069.83 1182.34
287 Divided poly(a) polymerase gamma (ec 2.7.7.19) (pap gamma) (polynucleotide adenylyltransferase gamma) (srp rna 3' adenylating enzyme). [swissprot;acc:q9bwt3] 19279.5 23303.1 1.2087
Subtracted apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576] 5252.17 4069.83 1182.34
288 Divided cleavage and polyadenylation specificity factor, 73 kda subunit (cpsf 73 kda subunit). [swissprot;acc:q9ukf6] 19380.3 23422.4 1.20857
Subtracted ns1-associated protein 1. [refseq;acc:nm_006372] 5252.17 4069.83 1182.34
289 Divided u6 snrna-associated sm-like protein lsm6 (sm protein f). [swissprot;acc:q9y4y8] 5646.19 4682.88 1.20571
Subtracted heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390] 5252.17 4069.83 1182.34
290 Divided tuftelin-interacting protein 11 (hspc006). [swissprot;acc:q9ubb9] 6014.08 4991.48 1.20487
Subtracted eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637] 5251.75 4071.1 1180.65
291 Divided putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172] 36927.5 44490.5 1.20481
Subtracted pallidin; pallid (mouse) homolog, pallidin. [refseq;acc:nm_012388] 7073.65 5894.75 1178.9
292 Divided nucleotide-binding protein 1 (nbp 1). [swissprot;acc:p53384] 5588.75 4641.09 1.20419
Subtracted protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690] 2108.52 950.561 1157.96
293 Divided nucleotide binding protein 2 (nbp 2). [swissprot;acc:q9y5y2] 5588.75 4641.09 1.20419
Subtracted small nuclear ribonucleoprotein e (snrnp-e) (sm protein e) (sm-e) (sme). [swissprot;acc:p08578] 5655.52 4512.19 1143.33
294 Divided cleavage stimulation factor subunit 3; cleavage stimulation factor, 3' pre-rna, subunit 3, 77kd. [refseq;acc:nm_001326] 18702.6 22515.5 1.20387
Subtracted small nuclear ribonucleoprotein f (snrnp-f) (sm protein f) (sm-f) (smf). [swissprot;acc:q15356] 5655.52 4512.19 1143.33
295 Divided ral guanine nucleotide dissociation stimulator-like 1 (ralgds-like 1). [swissprot;acc:q9nzl6] 11017.8 13261.9 1.20368
Subtracted atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915] 4577.5 5720.25 1142.75
296 Divided splicing factor 3a subunit 2 (spliceosome associated protein 62) (sap 62) (sf3a66). [swissprot;acc:q15428] 5909.18 4911.81 1.20306
Subtracted nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952] 4763.34 3620.77 1142.57
297 Divided krueppel-like factor 5 (intestinal-enriched krueppel-like factor) (colon krueppel-like factor) (transcription factor bteb2) (basic transcription element binding protein 2) (bte-binding protein 2) (gc box binding protein 2). [swissprot;acc:q13887] 5909.18 4911.81 1.20306
Subtracted ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511] 4763.34 3620.77 1142.57
298 Divided u6 snrna-associated sm-like protein lsm2 (small nuclear ribonuclear protein d homolog) (g7b) (snrnp core sm-like protein sm-x5). [swissprot;acc:q9y333] 5572.85 4633.92 1.20262
Subtracted adrenodoxin, mitochondrial precursor (adrenal ferredoxin) (hepatoredoxin) (ferredoxin 1). [swissprot;acc:p10109] 9405.85 8268.19 1137.66
299 Divided ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36] 5907.12 4914.27 1.20203
Subtracted metaxin 1. [swissprot;acc:q13505] 10442.2 9327.58 1114.62
300 Divided u2 small nuclear ribonucleoprotein a' (u2 snrnp-a'). [swissprot;acc:p09661] 5907.12 4914.27 1.20203
Subtracted transcription factor iiib 90 kda subunit (tfiiib90) (htfiiib90) (b- related factor 1) (hbrf) (tata box-binding protein-associated factor, rna polymerase iii, subunit 2) (taf3b2). [swissprot;acc:q92994] 5553.79 4446.72 1107.07

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/