Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 5458 to 5507 of 7460 in total
Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1
Rank
description
Network Comparison Type
red
green
network_comparison
2227 delta-aminolevulinic acid dehydratase (ec 4.2.1.24) (porphobilinogen synthase) (aladh). [swissprot;acc:p13716] Subtracted 217.185 218.498 1.313
2228 hsp90 co-chaperone cdc37 (hsp90 chaperone protein kinase-targeting subunit) (p50cdc37). [swissprot;acc:q16543] 223.888 225.191 1.303
nadph:adrenodoxin oxidoreductase, mitochondrial precursor (ec 1.18.1.2) (adrenodoxin reductase) (ar) (ferredoxin-nadp(+) reductase). [swissprot;acc:p22570] Divided 211.81 213.153 1.00634
2229 60s ribosomal protein l22 (epstein-barr virus small rna associated protein) (eber associated protein) (eap) (heparin binding protein hbp15). [swissprot;acc:p35268] Subtracted 199.129 200.413 1.284
destrin (actin-depolymerizing factor) (adf). [swissprot;acc:p18282] Divided 217.955 219.336 1.00634
2230 sin3 associated polypeptide p30; sin3-associated polypeptide, 30kd. [refseq;acc:nm_003864] Subtracted 199.129 200.413 1.284
ubiquitin fusion degradation protein 1 homolog (ub fusion protein 1). [swissprot;acc:q92890] Divided 217.955 219.336 1.00634
2231 clathrin coat assembly protein ap50 (clathrin coat associated protein ap50) (plasma membrane adaptor ap-2 50 kda protein) (ha2 50 kda subunit) (clathrin assembly protein complex 2 medium chain) (ap-2 mu 2 chain). [swissprot;acc:p20172] Subtracted 199.129 200.413 1.284
hrd1 protein isoform a; synoviolin1. [refseq;acc:nm_032431] Divided 221.842 223.246 1.00633
2232 43 kda receptor-associated protein of the synapse (rapsyn) (acetylcholine receptor-associated 43 kda protein) (43 kda postsynaptic protein). [swissprot;acc:q13702] 215.547 214.194 1.00632
atp-binding cassette, sub-family c, member 10; multidrug resistance-associated protein 7. [refseq;acc:nm_033450] Subtracted 199.129 200.413 1.284
2233 lysosomal alpha-mannosidase precursor (ec 3.2.1.24) (mannosidase, alpha b) (lysosomal acid alpha-mannosidase) (laman) (mannosidase alpha class 2b member 1). [swissprot;acc:o00754]
tripartite motif protein 3 (ring finger protein 22) (brain-expressed ring finger protein). [swissprot;acc:o75382] Divided 202.414 203.691 1.00631
2234 rna polymerase i transcription factor rrn3. [refseq;acc:nm_018427] Subtracted 199.129 200.413 1.284
seven in absentia homolog 1. [refseq;acc:nm_003031] Divided 223.608 225.005 1.00625
2235 arginyl-trna synthetase-like; arginine-trna ligase. [refseq;acc:nm_020320] 200.95 199.711 1.0062
insulin gene enhancer protein isl-2 (islet-2). [swissprot;acc:q96a47] Subtracted 196.748 195.466 1.282
2236 integral membrane protein 2b (transmembrane protein bri) [contains: abri/adan amyloid peptide]. [swissprot;acc:q9y287] 209.197 207.915
protein regulator of cytokinesis 1; protein regulating cytokinesis 1. [refseq;acc:nm_003981] Divided 222.959 224.337 1.00618
2237 bromodomain-containing protein 3 (ring3-like protein). [swissprot;acc:q15059] 222.965 224.343
integral membrane protein 2c (transmembrane protein bri3) (npd018). [swissprot;acc:q9nqx7] Subtracted 209.197 207.915 1.282
2238 bromodomain-containing protein 4 (hunk1 protein). [swissprot;acc:o60885] Divided 222.959 224.337 1.00618
integral membrane protein 2a (e25 protein). [swissprot;acc:o43736] Subtracted 209.197 207.915 1.282
2239 testis-specific bromodomain protein. [refseq;acc:nm_001726] Divided 222.958 224.336 1.00618
ubiquinone biosynthesis monooxgenase coq6 (ec 1.14.13.-) (cgi-10). [swissprot;acc:q9y2z9] Subtracted 193.787 195.064 1.277
2240 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase). [refseq;acc:nm_003679]
nag14 protein. [refseq;acc:nm_022143] Divided 222.959 224.337 1.00618
2241 bromodomain-containing protein 2 (ring3 protein) (o27.1.1). [swissprot;acc:p25440] 222.96 224.338
tripartite motif protein 3 (ring finger protein 22) (brain-expressed ring finger protein). [swissprot;acc:o75382] Subtracted 202.414 203.691 1.277
2242 integral membrane protein 2b (transmembrane protein bri) [contains: abri/adan amyloid peptide]. [swissprot;acc:q9y287] Divided 209.197 207.915 1.00617
squalene monooxygenase (ec 1.14.99.7) (squalene epoxidase) (se). [swissprot;acc:q14534] Subtracted 193.787 195.064 1.277
2243 integral membrane protein 2c (transmembrane protein bri3) (npd018). [swissprot;acc:q9nqx7] Divided 209.197 207.915 1.00617
tumor susceptibility gene 101 protein. [swissprot;acc:q99816] Subtracted 195.97 194.7 1.27
2244 integral membrane protein 2a (e25 protein). [swissprot;acc:o43736] Divided 209.197 207.915 1.00617
sipl protein. [refseq;acc:nm_018269] Subtracted 208.609 207.346 1.263
2245 e-1 enzyme. [refseq;acc:nm_021204] 208.315 207.061 1.254
fibulin-2 precursor. [swissprot;acc:p98095] Divided 191.618 190.448 1.00614
2246 leng5 protein. [refseq;acc:nm_024075] Subtracted 221.599 220.351 1.248
mitochondrial ribosomal protein l18. [refseq;acc:nm_014161] Divided 223.58 224.943 1.0061
2247 sipl protein. [refseq;acc:nm_018269] 208.609 207.346 1.00609
tryptophanyl-trna synthetase (ec 6.1.1.2) (tryptophan--trna ligase) (trprs) (ifp53) (hwrs). [swissprot;acc:p23381] Subtracted 221.599 220.351 1.248
2248 kinesin-like protein kif3c. [swissprot;acc:o14782] Divided 219.045 220.377 1.00608
ribulose-5-phosphate-3-epimerase; ribulose 5-phosphate 3-epimerase. [refseq;acc:nm_006916] Subtracted 221.599 220.351 1.248
2249 pyruvate carboxylase, mitochondrial precursor (ec 6.4.1.1) (pyruvic carboxylase) (pcb). [swissprot;acc:p11498] Divided 181.091 179.999 1.00607
tryptophanyl-trna synthetase, mitochondrial precursor (ec 6.1.1.2) (tryptophan--trna ligase) (trprs) ((mt)trprs). [swissprot;acc:q9ugm6] Subtracted 221.599 220.351 1.248
2250 likely ortholog of mouse variant polyadenylation protein cstf-64. [refseq;acc:nm_015235] Divided 164.064 165.058 1.00606
thiamin pyrophosphokinase 1; mouse thiamin pyrophosphokinase homolog; thiamine pyrophosphokinase. [refseq;acc:nm_022445] Subtracted 221.599 220.351 1.248
2251 e-1 enzyme. [refseq;acc:nm_021204] Divided 208.315 207.061 1.00606
nicotinate-nucleotide pyrophosphorylase [carboxylating] (ec 2.4.2.19) (quinolinate phosphoribosyltransferase [decarboxylating]) (qaprtase) (qprtase). [swissprot;acc:q15274] Subtracted 212.563 211.315 1.248
2252 arginyl-trna synthetase-like; arginine-trna ligase. [refseq;acc:nm_020320] 200.95 199.711 1.239

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/