Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Value Type Gene Rank Interaction Map Network Comparison Type red description Filtered green network_comparison
Results: HTML CSV LaTeX Showing element 451 to 500 of 29840 in total
Value Type  : Measured
Interaction Map  : High confidence
Rank
Network Comparison Type
red
description
Filtered
green
network_comparison
113 Subtracted 3117.17 transcription factor cp2; transcription factor cp2, alpha globin. [refseq;acc:nm_005653] 0 2833.94 283.23
4800.81 cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847] 1 7132.71 2331.9
114 Divided 671.769 daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959] 0 472.945 1.4204
4300.47 huntingtin interacting protein c. [refseq;acc:nm_012272] 1 5807.72 1.35048
Subtracted 305.45 60s ribosomal protein l37a. [swissprot;acc:p12751] 0 26.1599 279.29
13768.2 cyclin-dependent kinases regulatory subunit 1 (cks-1) (sid1334) (pnas-16 / pnas-143). [swissprot;acc:p33551] 1 11466 2302.2
115 Divided 385 zinc finger protein-like 1; zinc-finger protein in men1 region. [refseq;acc:nm_006782] 0 543 1.41039
21185 28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5] 1 28492 1.34491
Subtracted 305.45 25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528] 0 26.1599 279.29
13680.5 pnas-18. [sptrembl;acc:q9bzu3] 1 11409.6 2270.9
116 Divided 668 alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7] 0 475 1.40632
21185 pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04] 1 28492 1.34491
Subtracted 1382.5 cylindromatosis (turban tumor syndrome); cylindromatosis 1, turban tumor syndrome. [refseq;acc:nm_015247] 0 1107 275.5
13261.9 ral guanine nucleotide dissociation stimulator-like 1 (ralgds-like 1). [swissprot;acc:q9nzl6] 1 11017.8 2244.1
117 Divided 170.5 ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395] 0 122 1.39754
21185 pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23] 1 28492 1.34491
Subtracted 1161.88 ccr4-not transcription complex, subunit 7 (ccr4-associated factor 1) (caf1) (btg1 binding factor 1). [swissprot;acc:q9uiv1] 0 891.114 270.766
9276.47 metalloprotease 1; metalloprotease 1 (pitrilysin family). [refseq;acc:nm_014889] 1 7090.37 2186.1
118 Divided 31 methyltransferase like 2. [refseq;acc:nm_018396] 0 43 1.3871
21185 pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999] 1 28492 1.34491
Subtracted 324.442 glutathione s-transferase theta 2 (ec 2.5.1.18) (gst class-theta). [swissprot;acc:p30712] 0 593.094 268.652
9275.1 beta-1,4 mannosyltransferase. [refseq;acc:nm_019109] 1 7089.65 2185.45
119 Divided 633.85 estrogen-related receptor gamma (estrogen receptor related protein 3) (err gamma-2). [swissprot;acc:o75454] 0 460.2 1.37734
21185 mitochondrial solute carrier protein. [refseq;acc:nm_145305] 1 28492 1.34491
Subtracted 620 ubiquitin protein ligase. [refseq;acc:nm_130466] 0 352.75 267.25
12998.5 acyl-coa dehydrogenase, very-long-chain specific, mitochondrial precursor (ec 1.3.99.-) (vlcad). [swissprot;acc:p49748] 1 15138.2 2139.7
120 Divided 494.417 signal-induced proliferation-associated 1-like 1. [refseq;acc:nm_015556] 0 359.631 1.37479
5136.78 high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339] 1 6895.98 1.34247
Subtracted 817.81 transducin beta-like 2 protein (ws beta-transducin repeats protein) (ws-betatrp) (williams-beuren syndrome chromosome region 13 protein). [swissprot;acc:q9y4p3] 0 551.434 266.376
4932.27 proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100] 1 7033.29 2101.02
121 Divided 19.6667 4-aminobutyrate aminotransferase, mitochondrial precursor (ec 2.6.1.19) (gamma-amino-n-butyrate transaminase) (gaba transaminase) (gaba aminotransferase) (gaba-at) (gaba-t). [swissprot;acc:p80404] 0 14.3333 1.3721
5579.18 transcription factor jun-b. [swissprot;acc:p17275] 1 7488.4 1.3422
Subtracted 874 presenilin-like protein 1 (ec 3.4.99.-) (sppl2b protein). [swissprot;acc:q8tct7] 0 1139 265
4932.27 jun dimerization protein. [refseq;acc:nm_130469] 1 7033.29 2101.02
122 Divided 107 sh2-b homolog; likely ortholog of mouse sh2 domain-containing putative adapter sh2-b; sh2-b gamma signaling protein; sh2-b alpha signaling protein. [refseq;acc:nm_015503] 0 78 1.37179
5140.14 high-mobility group 20a. [refseq;acc:nm_018200] 1 6893.53 1.34112
Subtracted 2198.47 casein kinase i alpha s-like. [refseq;acc:nm_145203] 0 1933.94 264.53
4941.95 fos-related antigen 2. [swissprot;acc:p15408] 1 7037.11 2095.16
123 Divided 2285.62 ret finger protein 2 (leukemia associated protein 5) (b-cell chronic lymphocytic leukemia tumor suppressor leu5) (putative tumor suppressor rfp2) (tripartite motif protein 13). [swissprot;acc:o60858] 0 1681.3 1.35944
24260.3 cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936] 1 18172.1 1.33503
Subtracted 1905.84 putative nucleoside diphosphate kinase (ec 2.7.4.6) (ndk) (ndp kinase). [swissprot;acc:o60361] 0 1643 262.84
4942.49 protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539] 1 7037.32 2094.83
124 Divided 3248.95 regulator of chromosome condensation (cell cycle regulatory protein). [swissprot;acc:p18754] 0 2399.76 1.35386
24255.7 microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8] 1 18168.9 1.33501
Subtracted 2155.75 brain protein 16. [refseq;acc:nm_016458] 0 2418.14 262.39
4944.3 fos-related antigen 1 (fra-1). [swissprot;acc:p15407] 1 7038.04 2093.74
125 Divided 1095.42 probable calcium-transporting atpase kiaa0703 (ec 3.6.3.8). [swissprot;acc:o75185] 0 812.166 1.34876
24255.7 microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492] 1 18168.9 1.33501
Subtracted 3691.15 glutamate dehydrogenase 2, mitochondrial precursor (ec 1.4.1.3) (gdh). [swissprot;acc:p49448] 0 3952.59 261.44
12471.7 hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0] 1 14561.7 2090

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/