Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Value Type Rank Interaction Map Gene Filtered description Network Comparison Type green red network_comparison
Results: HTML CSV LaTeX Showing element 451 to 500 of 29840 in total
Value Type  : Measured
Interaction Map  : High confidence
Rank
Filtered
description
Network Comparison Type
green
red
network_comparison
113 1 cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847] Subtracted 7132.71 4800.81 2331.9
filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333] Divided 5899.76 4366.44 1.35116
114 0 60s ribosomal protein l37a. [swissprot;acc:p12751] Subtracted 26.1599 305.45 279.29
daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959] Divided 472.945 671.769 1.4204
1 cyclin-dependent kinases regulatory subunit 1 (cks-1) (sid1334) (pnas-16 / pnas-143). [swissprot;acc:p33551] Subtracted 11466 13768.2 2302.2
huntingtin interacting protein c. [refseq;acc:nm_012272] Divided 5807.72 4300.47 1.35048
115 0 25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528] Subtracted 26.1599 305.45 279.29
zinc finger protein-like 1; zinc-finger protein in men1 region. [refseq;acc:nm_006782] Divided 543 385 1.41039
1 28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5] 28492 21185 1.34491
pnas-18. [sptrembl;acc:q9bzu3] Subtracted 11409.6 13680.5 2270.9
116 0 alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7] Divided 475 668 1.40632
cylindromatosis (turban tumor syndrome); cylindromatosis 1, turban tumor syndrome. [refseq;acc:nm_015247] Subtracted 1107 1382.5 275.5
1 pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04] Divided 28492 21185 1.34491
ral guanine nucleotide dissociation stimulator-like 1 (ralgds-like 1). [swissprot;acc:q9nzl6] Subtracted 11017.8 13261.9 2244.1
117 0 ccr4-not transcription complex, subunit 7 (ccr4-associated factor 1) (caf1) (btg1 binding factor 1). [swissprot;acc:q9uiv1] 891.114 1161.88 270.766
ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395] Divided 122 170.5 1.39754
1 metalloprotease 1; metalloprotease 1 (pitrilysin family). [refseq;acc:nm_014889] Subtracted 7090.37 9276.47 2186.1
pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23] Divided 28492 21185 1.34491
118 0 glutathione s-transferase theta 2 (ec 2.5.1.18) (gst class-theta). [swissprot;acc:p30712] Subtracted 593.094 324.442 268.652
methyltransferase like 2. [refseq;acc:nm_018396] Divided 43 31 1.3871
1 beta-1,4 mannosyltransferase. [refseq;acc:nm_019109] Subtracted 7089.65 9275.1 2185.45
pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999] Divided 28492 21185 1.34491
119 0 estrogen-related receptor gamma (estrogen receptor related protein 3) (err gamma-2). [swissprot;acc:o75454] 460.2 633.85 1.37734
ubiquitin protein ligase. [refseq;acc:nm_130466] Subtracted 352.75 620 267.25
1 acyl-coa dehydrogenase, very-long-chain specific, mitochondrial precursor (ec 1.3.99.-) (vlcad). [swissprot;acc:p49748] 15138.2 12998.5 2139.7
mitochondrial solute carrier protein. [refseq;acc:nm_145305] Divided 28492 21185 1.34491
120 0 signal-induced proliferation-associated 1-like 1. [refseq;acc:nm_015556] 359.631 494.417 1.37479
transducin beta-like 2 protein (ws beta-transducin repeats protein) (ws-betatrp) (williams-beuren syndrome chromosome region 13 protein). [swissprot;acc:q9y4p3] Subtracted 551.434 817.81 266.376
1 high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339] Divided 6895.98 5136.78 1.34247
proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100] Subtracted 7033.29 4932.27 2101.02
121 0 4-aminobutyrate aminotransferase, mitochondrial precursor (ec 2.6.1.19) (gamma-amino-n-butyrate transaminase) (gaba transaminase) (gaba aminotransferase) (gaba-at) (gaba-t). [swissprot;acc:p80404] Divided 14.3333 19.6667 1.3721
presenilin-like protein 1 (ec 3.4.99.-) (sppl2b protein). [swissprot;acc:q8tct7] Subtracted 1139 874 265
1 jun dimerization protein. [refseq;acc:nm_130469] 7033.29 4932.27 2101.02
transcription factor jun-b. [swissprot;acc:p17275] Divided 7488.4 5579.18 1.3422
122 0 casein kinase i alpha s-like. [refseq;acc:nm_145203] Subtracted 1933.94 2198.47 264.53
sh2-b homolog; likely ortholog of mouse sh2 domain-containing putative adapter sh2-b; sh2-b gamma signaling protein; sh2-b alpha signaling protein. [refseq;acc:nm_015503] Divided 78 107 1.37179
1 fos-related antigen 2. [swissprot;acc:p15408] Subtracted 7037.11 4941.95 2095.16
high-mobility group 20a. [refseq;acc:nm_018200] Divided 6893.53 5140.14 1.34112
123 0 putative nucleoside diphosphate kinase (ec 2.7.4.6) (ndk) (ndp kinase). [swissprot;acc:o60361] Subtracted 1643 1905.84 262.84
ret finger protein 2 (leukemia associated protein 5) (b-cell chronic lymphocytic leukemia tumor suppressor leu5) (putative tumor suppressor rfp2) (tripartite motif protein 13). [swissprot;acc:o60858] Divided 1681.3 2285.62 1.35944
1 cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936] 18172.1 24260.3 1.33503
protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539] Subtracted 7037.32 4942.49 2094.83
124 0 brain protein 16. [refseq;acc:nm_016458] 2418.14 2155.75 262.39
regulator of chromosome condensation (cell cycle regulatory protein). [swissprot;acc:p18754] Divided 2399.76 3248.95 1.35386
1 fos-related antigen 1 (fra-1). [swissprot;acc:p15407] Subtracted 7038.04 4944.3 2093.74
microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8] Divided 18168.9 24255.7 1.33501
125 0 glutamate dehydrogenase 2, mitochondrial precursor (ec 1.4.1.3) (gdh). [swissprot;acc:p49448] Subtracted 3952.59 3691.15 261.44
probable calcium-transporting atpase kiaa0703 (ec 3.6.3.8). [swissprot;acc:o75185] Divided 812.166 1095.42 1.34876
1 hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0] Subtracted 14561.7 12471.7 2090
microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492] Divided 18168.9 24255.7 1.33501

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/