MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 4258 to 4307 of 29840 in total

Interaction Map  : High confidence

Rank	description	Value Type	Network Comparison Type	Filtered	red	green	network_comparison
267	60s ribosomal protein l10 (qm protein) (tumor suppressor qm) (laminin receptor homolog). [swissprot;acc:p27635]	Ranked	Subtracted	1	243.12	266.661	23.541
	cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]			0	10783	11674.1	891.1
	cyclin-dependent kinases regulatory subunit 2 (cks-2). [swissprot;acc:p33552]	Measured		1	11222.2	9948.93	1273.27
	density-regulated protein (drp) (drp1 protein) (smooth muscle cell associated protein-3) (smap-3). [swissprot;acc:o43583]	Ranked	Divided		241.07	267.88	1.11121
	disks large-associated protein 2 (dap-2) (sap90/psd-95-associated protein 2) (sapap2) (psd-95/sap90 binding protein 2) (fragment). [swissprot;acc:q9p1a6]	Measured	Subtracted	0	870.93	975.647	104.717
	estrogen-related receptor gamma (estrogen receptor related protein 3) (err gamma-2). [swissprot;acc:o75454]	Squared		1	59334.6	68040.1	8705.5
	leucine-rich repeat protein lrrc3 precursor. [swissprot;acc:q9by71]		Divided		26157.6	20236.2	1.29261
	mitogen-activated protein kinase kinase kinase 5 (ec 2.7.1.-) (mapk/erk kinase kinase 5) (mek kinase 5) (mekk 5) (apoptosis signal- regulating kinase 1) (ask-1). [swissprot;acc:q99683]			0	181.291	144.478	1.2548
	ral guanine nucleotide dissociation stimulator (ralgef) (ralgds). [swissprot;acc:q12967]	Measured		1	14021.4	11523	1.21682
	source of immunodominant mhc-associated peptides; homolog of yeast stt3 gene. [refseq;acc:nm_178862]	Rooted	Subtracted		61.2893	70.3856	9.0963
	transcription factor mafk (erythroid transcription factor nf-e2 p18 subunit). [swissprot;acc:o60675]		Divided	0	12.9585	14.1963	1.09552
	transcription initiation factor tfiid 135 kda subunit (tafii-135) (tafii135) (tafii-130) (tafii130). [swissprot;acc:o00268]	Ranked			8054.34	8772.02	1.0891
	tyrosine-protein kinase abl2 (ec 2.7.1.112) (tyrosine kinase arg). [swissprot;acc:p42684]	Rooted		1	66.1064	74.1073	1.12103
	uncharacterized bone marrow protein bm033. [refseq;acc:nm_018452]	Measured		0	1475.05	1312.91	1.1235
	zinc finger protein 232. [swissprot;acc:q9uny5]	Squared	Subtracted		3778.04	3908.95	130.91
268	adenylyl cyclase-associated protein 2 (cap 2). [swissprot;acc:p40123]	Ranked			10438.3	9549.77	888.53
	catenin (cadherin-associated protein), alpha-like 1; alpha-catulin. [refseq;acc:nm_003798]	Measured		1	11222.2	9948.93	1273.27
	cleavage and polyadenylation specificity factor, 100 kda subunit (cpsf 100 kda subunit) (fragment). [swissprot;acc:q9p2i0]		Divided		24473.9	20127.8	1.21593
	creatine kinase, ubiquitous mitochondrial precursor (ec 2.7.3.2) (u- mtck) (mia-ck) (acidic-type mitochondrial creatine kinase). [swissprot;acc:p12532]		Subtracted	0	861.401	759.896	101.505
	eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]	Ranked	Divided	1	271.016	244.167	1.10996
	far upstream element-binding protein; far upstream element binding protein; fuse-binding protein. [refseq;acc:nm_003902]	Measured		0	604.529	538.094	1.12346
	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	Rooted	Subtracted		13.9593	11.8643	2.095
	hsp90 co-chaperone cdc37 (hsp90 chaperone protein kinase-targeting subunit) (p50cdc37). [swissprot;acc:q16543]	Squared			220.039	350.57	130.531
	laminin gamma-1 chain precursor (laminin b2 chain). [swissprot;acc:p11047]		Divided	1	26157.6	20236.2	1.29261
	maguk p55 subfamily member 2 (mpp2 protein) (discs, large homolog 2). [swissprot;acc:q14168]	Ranked		0	14257.4	13134.5	1.08549
	oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977]	Rooted	Subtracted	1	61.2893	70.3856	9.0963
	protein arginine n-methyltransferase 3 (ec 2.1.1.-) (fragment). [swissprot;acc:o60678]	Ranked			241.625	265.136	23.511
	protein cgi-147. [swissprot;acc:q9y3e5]	Squared	Divided	0	75129.2	94178	1.25355
	proto-oncogene tyrosine-protein kinase src (ec 2.7.1.112) (p60-src) (c-src). [swissprot;acc:p12931]	Rooted		1	66.1064	74.1074	1.12103
	sh3-containing grb2-like protein 2 (sh3 domain protein 2a) (endophilin 1) (een-b1). [swissprot;acc:q99962]	Squared	Subtracted		35533.9	44227	8693.1
	transcription factor mafg (v-maf musculoaponeurotic fibrosarcoma oncogene homolog g) (hmaf). [swissprot;acc:o15525]	Rooted	Divided	0	13.0249	14.2577	1.09465
269	40s ribosomal protein s2 (s4) (llrep3 protein). [swissprot;acc:p15880]	Ranked	Subtracted	1	241.625	265.136	23.511
	60s ribosomal protein l10 (qm protein) (tumor suppressor qm) (laminin receptor homolog). [swissprot;acc:p27635]	Measured	Divided	0	1217.92	1367.83	1.12309
	60s ribosomal protein l17 (l23). [swissprot;acc:p18621]	Squared			4121.56	5159.2	1.25176
	60s ribosomal protein l23 (l17). [swissprot;acc:p23131]	Rooted	Subtracted		28.0195	30.112	2.0925
	armet protein precursor (arginine-rich protein). [swissprot;acc:p55145]	Squared		1	35508.7	44191.4	8682.7
	cholinephosphate cytidylyltransferase a (ec 2.7.7.15) (phosphorylcholine transferase a) (ctp:phosphocholine cytidylyltransferase a) (ct a) (cct a) (cct-alpha). [swissprot;acc:p49585]	Ranked	Divided		241.373	267.352	1.10763
	crk-associated substrate (p130cas) (breast cancer anti-estrogen resistance 1 protein). [swissprot;acc:p56945]	Measured	Subtracted		4808.79	6074.21	1265.42
	dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kda subunit precursor (ec 2.4.1.119) (oligosaccharyl transferase 48 kda subunit) (ddost 48 kda subunit). [swissprot;acc:p39656]	Rooted			61.2893	70.3856	9.0963
	ischemia/reperfusion inducible protein. [refseq;acc:nm_024640]	Ranked	Divided	0	12463.5	11482.6	1.08542
	mto1 protein homolog (cgi-02). [swissprot;acc:q9y2z2]		Subtracted		8907.41	9795.36	887.95
	presenilin-like protein 1 (ec 3.4.99.-) (sppl2b protein). [swissprot;acc:q8tct7]	Squared			180.799	307.058	126.259
	similar to zinc finger protein 277. [sptrembl;acc:q8wwa6]	Rooted	Divided		90.4079	98.9265	1.09422
	syntaxin 10 (syn10). [swissprot;acc:o60499]	Measured	Subtracted		118.878	17.6611	101.217
	thymic stromal co-transporter. [refseq;acc:nm_033051]	Squared	Divided	1	26157.6	20236.2	1.29261
	tyrosine-protein kinase hck (ec 2.7.1.112) (p59-hck/p60-hck) (hemopoietic cell kinase). [swissprot;acc:p08631]	Rooted			66.1064	74.1074	1.12103
	u6 snrna-associated sm-like protein lsm8. [swissprot;acc:o95777]	Measured			4590.18	5575.52	1.21466
270	40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174]	Squared		0	2569.37	3201.81	1.24615
	40s ribosomal protein s3. [swissprot;acc:p23396]	Ranked	Subtracted	1	241.612	265.119	23.507
	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]			0	11644	10763.4	880.6

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.