MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 410 to 459 of 3228 in total

Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	red	green	network_comparison
410	docking protein 1 (p62(dok)) (downstream of tyrosine kinase 1) (pp62). [swissprot;acc:q99704]	6102.59	7081.46	1.1604
411	tyrosine-protein kinase frk (ec 2.7.1.112) (nuclear tyrosine protein kinase rak). [swissprot;acc:p42685]
412	mki67 (fha domain) interacting nucleolar phosphoprotein; nucleolar phosphoprotein nopp34; nucleolar protein interacting with the fha domain of pki-67. [refseq;acc:nm_032390]	3594.31	4169.95	1.16015
413	vav proto-oncogene. [swissprot;acc:p15498]	6644.99	7707.8	1.15994
414	autophagy protein 5-like (apg5-like) (apoptosis-specific protein). [swissprot;acc:q9h1y0]	6744.05	5815.13	1.15974
415	vav-3 protein. [swissprot;acc:q9ukw4]	6647.43	7706.18	1.15927
416	n-terminal acetyltransferase complex ard1 subunit homolog (ec 2.3.1.-). [swissprot;acc:p41227]	4509.54	5223.95	1.15842
417	bag-family molecular chaperone regulator-3 (bcl-2 binding athanogene- 3) (bag-3) (bcl-2-binding protein bis) (docking protein cair-1). [swissprot;acc:o95817]	4522.71	5233.14	1.15708
418	breast carcinoma amplified sequence 2; spliceosome associated protein, amplified in breast cancer. [refseq;acc:nm_005872]	5493.1	6350.19	1.15603
419	cdc5-like; cdc5 (cell division cycle 5, s. pombe, homolog)-like; cell division cycle 5, s. pombe, homolog-like; cdc5-related protein. [refseq;acc:nm_001253]
420	hypoxanthine-guanine phosphoribosyltransferase (ec 2.4.2.8) (hgprt) (hgprtase). [swissprot;acc:p00492]	10235.2	11830.8	1.15589
421	vav-2 protein. [swissprot;acc:p52735]	6660.02	7697.78	1.15582
422	nuclear rna export factor 5 (tap-like protein 1) (tapl-1). [swissprot;acc:q9h1b4]	5206.9	6010.04	1.15425
423	nuclear rna export factor 3 (tap-like protein 3) (tapl-3). [swissprot;acc:q9h4d5]	5207.03	6010.1	1.15423
424	nuclear rna export factor 1 (tip associating protein) (tip-associated protein) (mrna export factor tap). [swissprot;acc:q9ubu9]	5207.78	6010.45	1.15413
425	saccharomyces cerevisiae nip7p homolog. [refseq;acc:nm_016101]	3729.02	4301.58	1.15354
426	pef protein with a long n-terminal hydrophobic domain (peflin). [refseq;acc:nm_012392]	5942.49	6853.15	1.15325
427	trna (5-methylaminomethyl-2-thiouridylate)-methyltransferase (ec 2.1.1.61). [swissprot;acc:o75648]	11736.6	13531.9	1.15297
428	nucleolar gtp-binding protein 1 (chronic renal failure gene protein) (gtp-binding protein ngb). [swissprot;acc:q9bze4]	3721.19	4288.17	1.15237
429	vinexin (sh3-containing adaptor molecule-1) (scam-1). [swissprot;acc:o60504]	6272.91	7226.06	1.15195
430	transcription factor dp-2 (e2f dimerization partner 2). [swissprot;acc:q14188]	3804.09	4379.37	1.15123
431	dead (asp-glu-ala-asp) box polypeptide 31 isoform 1; dead/dexh helicase ddx31. [refseq;acc:nm_022779]	3849.94	4431.36	1.15102
432	mitochondrial processing peptidase beta subunit, mitochondrial precursor (ec 3.4.24.64) (beta-mpp) (p-52). [swissprot;acc:o75439]	5244.71	6036.27	1.15093
433	mitochondrial processing peptidase alpha subunit, mitochondrial precursor (ec 3.4.24.64) (alpha-mpp) (p-55) (ha1523). [swissprot;acc:q10713]	5244.88	6036.38	1.15091
434	ubiquinol-cytochrome c reductase complex core protein i, mitochondrial precursor (ec 1.10.2.2). [swissprot;acc:p31930]	5246.38	6037.37	1.15077
435	proline synthetase co-transcribed bacterial homolog protein. [swissprot;acc:o94903]	5233.86	6022.6	1.1507
436	arg/abl-interacting protein 2 isoform 2; arg binding protein 2. [refseq;acc:nm_021069]	6230.94	7168.2	1.15042
437	suppressor of swi4 1 homolog (ssf-1) (peter pan homolog). [swissprot;acc:q9nq55]	3779.92	4348.48
438	swi/snf-related, matrix-associated, actin-dependent regulator of chromatin subfamily f member 1 (swi-snf complex protein p270) (b120). [swissprot;acc:o14497]	6252.58	7192.88	1.15039
439	programmed cell death protein 6 (probable calcium-binding protein alg- 2). [swissprot;acc:o75340]
440	calcium-dependent protease, small subunit (calpain regulatory subunit) (calcium-activated neutral proteinase) (canp). [swissprot;acc:p04632]	6251.91	7192.08	1.15038
441	grancalcin. [swissprot;acc:p28676]	6251.96	7192.13
442	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]	6251.99	7192.17
443	brg1-binding protein eld/osa1; eld (eyelid)/osa protein. [refseq;acc:nm_020732]	6252.27	7192.51
444	probable rrna processing protein ebp2 (ebna1 binding protein 2) (nucleolar protein p40). [swissprot;acc:q99848]	3758.67	4322.87	1.15011
445	ad24 protein. [refseq;acc:nm_022451]	3753.71	4315.95	1.14978
446	nucleostemin; putative nucleotide binding protein, estradiol-induced. [refseq;acc:nm_014366]	3766.03	4329.37	1.14958
447	pescadillo homolog 1. [swissprot;acc:o00541]	3751.14	4310.89	1.14922
448	ponsin; sh3-domain protein 5 (ponsin). [refseq;acc:nm_015385]	6259.3	7190.91	1.14884
449	wd-repeat protein 12 (ytm1 homolog). [swissprot;acc:q9gzl7]	3761.59	4319.69	1.14837
450	l-myc-1 proto-oncogene protein. [swissprot;acc:p12524]	4889.21	5610.52	1.14753
451	n-myc proto-oncogene protein. [swissprot;acc:p04198]	4889.71	5610.69	1.14745
452	zinc finger-like protein 9. [refseq;acc:nm_033414]	3760.8	4315.06	1.14738
453	membrane-associated transporter protein (aim-1 protein) (melanoma antigen aim1). [swissprot;acc:q9umx9]
454	guanine nucleotide-binding protein-like 1 (gtp-binding protein hsr1). [swissprot;acc:p36915]
455	ga binding protein alpha chain (gabp-alpha subunit) (transcription factor e4tf1-60) (nuclear respiratory factor-2 subunit alpha). [swissprot;acc:q06546]	4890.51	5610.95	1.14731
456	ga binding protein beta-2 chain (gabp-beta-2 subunit) (transcription factor e4tf1-47) (gapbp-2) (nuclear respiratory factor-2 subunit gamma). [swissprot;acc:q06545]
457	nadh-ubiquinone oxidoreductase 23 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-23kd) (ci-23kd) (tyky subunit). [swissprot;acc:o00217]
458	elongation of very long chain fatty acids protein 1 (cgi-88). [swissprot;acc:q9bw60]	4890.55	5610.96
459	myc proto-oncogene protein (c-myc). [swissprot;acc:p01106]	4892.16	5611.48	1.14704

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.