MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 3958 to 4007 of 6456 in total

Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
1979	kinesin heavy chain (ubiquitous kinesin heavy chain) (ukhc). [swissprot;acc:p33176]	Subtracted	6036.68	6379.44	342.76
1980	bile acid coenzyme a: amino acid n-acyltransferase; glycine n-choloyltransferase. [refseq;acc:nm_001701]	Divided	5830.46	6176.71	1.05939
	kinesin heavy chain isoform 5c (kinesin heavy chain neuron-specific 2). [swissprot;acc:o60282]	Subtracted	6036.68	6379.44	342.76
1981	inositol polyphosphate 5-phosphatase ocrl-1 (ec 3.1.3.36) (lowe's oculocerebrorenal syndrome protein). [swissprot;acc:q01968]	Divided	5475.74	5800.97	1.05939
	neuronal kinesin heavy chain (nkhc) (kinesin heavy chain isoform 5a) (kinesin heavy chain neuron-specific 1). [swissprot;acc:q12840]	Subtracted	6036.68	6379.44	342.76
1982	transcription factor iiia (factor a) (tfiiia). [swissprot;acc:q92664]
	uv excision repair protein rad23 homolog b (hhr23b) (xp-c repair complementing complex 58 kda protein) (p58). [swissprot;acc:p54727]	Divided	5475.74	5800.97	1.05939
1983	exocyst complex component sec3 (bm-012). [swissprot;acc:q9nv70]	Subtracted	6036.68	6379.44	342.76
	myosin vi. [swissprot;acc:q9um54]	Divided	5475.74	5800.97	1.05939
1984	kinesin light chain 1 (klc 1). [swissprot;acc:q07866]	Subtracted	6036.73	6379.48	342.75
	peroxisomal acyl-coenzyme a thioester hydrolase 2a (ec 3.1.2.2) (peroxisomal long-chain acyl-coa thioesterase 2) (zap128). [swissprot;acc:p49753]	Divided	5830.03	6176.1	1.05936
1985	potassium voltage-gated channel subfamily a member 2 (potassium channel kv1.2) (rbk2) (hbk5) (ngk1) (mk2) (hukiv). [swissprot;acc:p16389]	Subtracted	6674.58	7015.93	341.35
	scribble. [refseq;acc:nm_015356]	Divided	5516.89	5844.37	1.05936
1986	lap (leucine-rich repeats and pdz) and no pdz protein. [refseq;acc:nm_018214]		5517.24	5844.68	1.05935
	peptidylprolyl isomerase-like 4; cyclophilin-type peptidyl-prolyl cis-trans isomerase; ppiase; serologically defined breast cancer antigen ny-br-18. [refseq;acc:nm_139126]	Subtracted	6083.39	6423.12	339.73
1987	hydroxyindole o-methyltransferase (ec 2.1.1.4) (hiomt) (acetylserotonin o-methyltransferase) (asmt). [swissprot;acc:p46597]		5444.6	5783.95	339.35
	peroxisomal acyl-coa thioesterase 2b; likely ortholog of mouse peroxisomal acyl-coa thioesterase 2b. [refseq;acc:nm_152331]	Divided	5829.74	6175.69	1.05934
1988	protein translation factor sui1 homolog gc20. [swissprot;acc:o60739]		3559.49	3360.39	1.05925
	seven in absentia homolog 2. [refseq;acc:nm_005067]	Subtracted	5399.47	5737.79	338.32
1989	m-phase inducer phosphatase 2 (ec 3.1.3.48) (dual specificity phosphatase cdc25b). [swissprot;acc:p30305]	Divided	4383.34	4642.93	1.05922
	mitochondrial ribosomal protein l18. [refseq;acc:nm_014161]	Subtracted	5396.61	5733.93	337.32
1990	transcription factor-like protein mrg15 (morf-related gene 15 protein) (mortality factor 4-like 1) (msl3-1 protein) (hspc008/hspc061). [swissprot;acc:q9ubu8]	Divided	5045.67	5344.06	1.05914
	valyl-trna synthetase 2 (ec 6.1.1.9) (valine--trna ligase 2) (valrs 2) (g7a). [swissprot;acc:p26640]	Subtracted	5096.02	5432.63	336.61
1991	seven in absentia homolog 1. [refseq;acc:nm_003031]		5394.24	5730.73	336.49
	solute carrier family 2, facilitated glucose transporter, member 6 (glucose transporter type 6) (glucose transporter type 9). [swissprot;acc:q9ugq3]	Divided	5429.27	5749.69	1.05902
1992	solute carrier family 2, facilitated glucose transporter, member 8 (glucose transporter type 8) (glucose transporter type x1). [swissprot;acc:q9ny64]
	ubiquitin. [swissprot;acc:p02248]	Subtracted	7484.98	7821.11	336.13
1993	nucleoporin like 1. [refseq;acc:nm_014089]	Divided	6174.74	6538.73	1.05895
	rac gtpase activating protein 1; gtpase activating protein. [refseq;acc:nm_013277]	Subtracted	5521.07	5856.93	335.86
1994	potassium voltage-gated channel subfamily a member 1 (potassium channel kv1.1) (huki) (hbk1). [swissprot;acc:q09470]		6682.7	7018.29	335.59
	rho guanine nucleotide exchange factor 4 isoform a; apc-stimulated guanine nucleotide exchange factor. [refseq;acc:nm_015320]	Divided	6174.74	6538.73	1.05895
1995	adaptor-related protein complex 1, mu 1 subunit (mu-adaptin 1) (adaptor protein complex ap-1 mu-1 subunit) (golgi adaptor ha1/ap1 adaptin mu-1 subunit) (clathrin assembly protein assembly protein complex 1 medium chain 1) (clathrin coat assembly protein ap47) (clathrin coat associated protein ap47) (ap-mu chain family member mu1a). [swissprot;acc:q9bxs5]	Subtracted	5684.61	6018.72	334.11
	cdc42 guanine exchange factor 9; hpem-2 collybistin. [refseq;acc:nm_015185]	Divided	6174.74	6538.73	1.05895
1996	polypeptide n-acetylgalactosaminyltransferase 2; udp-galnac transferase 2. [refseq;acc:nm_004481]	Subtracted	6024.47	6356.56	332.09
	survival motor neuron protein (component of gems 1) (gemin1). [swissprot;acc:q16637]	Divided	5047.2	5344.68	1.05894
1997	ras-related c3 botulinum toxin substrate 1 (p21-rac1) (ras-like protein tc25). [swissprot;acc:p15154]
	similar to expressed sequence ai415388 (fragment). [sptrembl;acc:q8n428]	Subtracted	6024.47	6356.56	332.09
1998	adaptor-related protein complex 1, mu 2 subunit (mu-adaptin 2) (adaptor protein complex ap-1 mu-2 subunit) (golgi adaptor ha1/ap1 adaptin mu-2 subunit) (clathrin assembly protein assembly protein complex 1 medium chain 2) (ap-mu chain family member mu1b). [swissprot;acc:q9y6q5]		5671.62	6003.67	332.05
	ras-related c3 botulinum toxin substrate 3 (p21-rac3). [swissprot;acc:o14658]	Divided	5047.2	5344.68	1.05894
1999	nucleoporin 54kda; nucleoporin p54. [refseq;acc:nm_017426]
	potassium voltage-gated channel subfamily a member 4 (potassium channel kv1.4) (hk1) (hpcn2) (hbk4) (hukii). [swissprot;acc:p22459]	Subtracted	6688.64	7020.02	331.38
2000	ras-related c3 botulinum toxin substrate 2 (p21-rac2) (small g protein) (gx). [swissprot;acc:p15153]	Divided	5047.2	5344.68	1.05894
	similar to glucosamine-phosphate n-acetyltransferase (hypothetical protein flj33258). [sptrembl;acc:q96ek6]	Subtracted	5882.61	6213.34	330.73
2001	dna replication licensing factor mcm5 (cdc46 homolog) (p1-cdc46). [swissprot;acc:p33992]	Divided	5047.2	5344.68	1.05894
	splicing coactivator subunit srm300; rna binding protein; at-rich element binding factor. [refseq;acc:nm_016333]	Subtracted	5448.35	5777.35	329
2002	splicing factor u2af 35 kda subunit (u2 auxiliary factor 35 kda subunit) (u2 snrnp auxiliary factor small subunit). [swissprot;acc:q01081]
	survival of motor neuron protein-interacting protein 1 (smn- interacting protein 1) (component of gems 2) (gemin2). [swissprot;acc:o14893]	Divided	5047.2	5344.68	1.05894
2003	probable atp-dependent rna helicase ddx20 (dead-box protein 20) (dead- box protein dp 103) (component of gems 3) (gemin3). [swissprot;acc:q9uhi6]
	rna helicase-related protein; rna helicase-like protein; sf3b125 dead-box protein. [refseq;acc:nm_007372]	Subtracted	5448.35	5777.35	329
2004	splicing factor u2af 65 kda subunit (u2 auxiliary factor 65 kda subunit) (u2 snrnp auxiliary factor large subunit) (hu2af(65)). [swissprot;acc:p26368]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.