MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Network Comparison Type	Gene	Value Type	description	Rank	network_comparison	green	Filtered	Interaction Map	red

Results: HTML CSV LaTeX

Showing element 918 to 967 of 3228 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1
Interaction Map  : High confidence

description	Rank	network_comparison	green	red
elav-like protein 4 (paraneoplastic encephalomyelitis antigen hud) (hu-antigen d). [swissprot;acc:p26378]	1792	1.01193	215.199	217.766
electron transfer flavoprotein alpha-subunit, mitochondrial precursor (alpha-etf). [swissprot;acc:p13804]	2441	1.0033	180.732	180.137
electron transfer flavoprotein beta-subunit (beta-etf). [swissprot;acc:p38117]	2353	1.00436	183.027	182.232
electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor (ec 1.5.5.1) (etf-qo) (etf-ubiquinone oxidoreductase) (etf dehydrogenase) (electron-transferring- flavoprotein dehydrogenase). [swissprot;acc:q16134]	2016	1.00908	197.301	199.092
elks protein. [refseq;acc:nm_015064]	1061	1.03078	211.648	218.162
ell-associated factor 2; uncharacterized bone marrow protein bm040; testosterone regulated apoptosis inducer and tumor suppressor. [refseq;acc:nm_018456]	2921	1	0.00001	0.00001
elongation factor 1-alpha 1 (ef-1-alpha-1) (elongation factor 1 a-1) (eef1a-1) (elongation factor tu) (ef-tu). [swissprot;acc:p04720]	2433	1.00346	218.117	217.366
elongation factor 1-alpha 2 (ef-1-alpha-2) (elongation factor 1 a-2) (eef1a-2) (statin s1). [swissprot;acc:q05639]	2436
elongation factor 2 (ef-2). [swissprot;acc:p13639]	2557	1.00175	223.047	222.658
elongation factor ts, mitochondrial precursor (ef-ts) (ef-tsmt). [swissprot;acc:p43897]	3027	1	0.00001	0.00001
elongation of very long chain fatty acids protein 1 (cgi-88). [swissprot;acc:q9bw60]	886	1.03917	219.018	227.596
elongation protein 4 homolog; pax6 neighbor gene; chromosome 11 open reading frame 19. [refseq;acc:nm_019040]	1802	1.0118	214.481	217.011
endo-beta-n-acetylglucosaminidase. [refseq;acc:nm_022759]	1322	1.02294	156.275	159.86
endonuclease g, mitochondrial precursor (ec 3.1.30.-) (endo g). [swissprot;acc:q14249]	432	1.07934	229.411	212.547
endosome-associated fyve-domain protein. [refseq;acc:nm_014733]	3200	1	0.00001	0.00001
endothelial-derived gene 1. [refseq;acc:nm_025205]	1918	1.01015	200.18	202.211
enhancer of filamentation 1 (hef1) (crk-associated substrate-related protein) (cas-l) (casl) (pp105) (neural precursor cell expressed developmentally down-regulated 9). [swissprot;acc:q14511]	286	1.1052	203.251	224.633
enhancer of rudimentary homolog. [swissprot;acc:q14259]	2676	1.001	215.108	214.893
enhancer of zeste homolog 1 (enx-2). [swissprot;acc:q92800]	3090	1	0.00001	0.00001
enhancer of zeste homolog 2 (enx-1). [swissprot;acc:q15910]	3098
enigma protein; lim domain protein. [refseq;acc:nm_005451]	1929	1.01001	217.574	219.753
enoyl-coa hydratase, mitochondrial precursor (ec 4.2.1.17) (short chain enoyl-coa hydratase) (sceh) (enoyl-coa hydratase 1). [swissprot;acc:p30084]	1403	1.0212	180.823	184.656
enteropeptidase precursor (ec 3.4.21.9) (enterokinase). [swissprot;acc:p98073]	577	1.06477	210.944	224.606
enthoprotin; epsin 4; clathrin interacting protein localized in the trans-golgi region. [refseq;acc:nm_014666]	1612	1.0157	224.902	221.426
epidermal growth factor receptor kinase substrate eps8. [swissprot;acc:q12929]	1153	1.02676	216.146	221.93
epidermal growth factor receptor pathway substrate 8-like protein 1 isoform c; epidermal growth factor receptor pathway substrate 8-related protein 1; eps8-related protein 1. [refseq;acc:nm_139204]	1152	1.02682	216.143	221.939
epidermal growth factor receptor pathway substrate 8-like protein 2; eps8-related protein 2; epidermal growth factor receptor pathway substrate 8-related protein 2. [refseq;acc:nm_022772]	1158	1.02641	216.167	221.877
epidermal growth factor receptor precursor (ec 2.7.1.112) (receptor protein-tyrosine kinase erbb-1). [swissprot;acc:p00533]	2005	1.00919	222.971	225.019
epididymal secretory protein e1 precursor (niemann-pick disease type c2 protein) (epi-1) (he1) (epididymal secretory protein 14.6) (esp14.6). [swissprot;acc:q15668]	1339	1.02239	200.71	205.204
epithelial-cadherin precursor (e-cadherin) (uvomorulin) (cadherin-1) (cam 120/80). [swissprot;acc:p12830]	320	1.0995	265.96	241.892
epoxide hydrolase 1 (ec 3.3.2.3) (microsomal epoxide hydrolase) (epoxide hydratase). [swissprot;acc:p07099]	2446	1.00324	181.683	182.272
epsin 1; eh domain-binding mitotic phosphoprotein. [refseq;acc:nm_013333]	2430	1.00354	218.644	217.873
epsin 2 isoform b; eps15 binding protein. [refseq;acc:nm_014964]	2550	1.00184	217.988	217.587
epsin 3. [refseq;acc:nm_017957]	2297	1.00518	219.284	218.153
ergic-53 protein precursor (er-golgi intermediate compartment 53 kda protein) (lectin, mannose-binding 1) (gp58) (intracellular mannose specific lectin mr60). [swissprot;acc:p49257]	3177	1	0.00001	0.00001
ero1-like. [refseq;acc:nm_014584]	911	1.03805	209.207	217.168
erythroid differentiation and denucleation factor 1. [swissprot;acc:o60584]	1566	1.01646	224.767	221.128
erythroid differentiation-related factor 1. [refseq;acc:nm_015608]	3095	1	0.00001	0.00001
espin. [refseq;acc:nm_031475]	1257	1.02437	224.7	219.354
esterase d (ec 3.1.1.1). [swissprot;acc:p10768]	2429	1.00355	193.555	192.871
estradiol 17 beta-dehydrogenase 1 (ec 1.1.1.62) (17-beta-hsd 1) (placental 17-beta-hydroxysteroid dehydrogenase) (20 alpha- hydroxysteroid dehydrogenase) (20-alpha-hsd) (e2dh). [swissprot;acc:p14061]	1050	1.03097	217.998	211.449
estradiol 17 beta-dehydrogenase 4 (ec 1.1.1.62) (17-beta-hsd 4) (17-beta-hydroxysteroid dehydrogenase 4). [swissprot;acc:p51659]	1768	1.01219	187.534	185.276
estrogen-related receptor gamma (estrogen receptor related protein 3) (err gamma-2). [swissprot;acc:o75454]	1042	1.03132	181.127	186.799
ethanolamine kinase (ec 2.7.1.82) (eki). [swissprot;acc:q9hbu6]	2378	1.004	213.574	212.724
ethanolamine kinase-like protein eki2 (flj10761). [swissprot;acc:q9nvf9]	2377
ethanolamine-phosphate cytidylyltransferase (ec 2.7.7.14) (phosphorylethanolamine transferase) (ctp:phosphoethanolamine cytidylyltransferase). [swissprot;acc:q99447]	1758	1.01238	230.595	233.45
eukaryotic initiation factor 4a-i (eif-4a-i) (eif4a-i). [swissprot;acc:p04765]	2868	1	0.00001	0.00001
eukaryotic initiation factor 4a-ii (eif-4a-ii) (eif4a-ii). [swissprot;acc:q14240]	2888
eukaryotic peptide chain release factor subunit 1 (erf1) (eukaryotic release factor 1) (tb3-1) (c11 protein). [swissprot;acc:p46055]	772	1.04873	221.225	210.946
eukaryotic translation initiation factor 2 subunit 1 (eukaryotic translation initiation factor 2 alpha subunit) (eif-2-alpha) (eif- 2alpha) (eif-2a). [swissprot;acc:p05198]	1341	1.02234	231.491	226.433

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.