MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Value Type	Gene	description	Interaction Map	Network Comparison Type	network_comparison	Rank	green	Filtered	red

Results: HTML CSV LaTeX

Showing element 51 to 100 of 38536 in total

Value Type  : Measured
Network Comparison Type  : Divided

description	Interaction Map	network_comparison	Rank	green	Filtered	red
25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	High confidence	1	3079	0.00001	1	0.00001
		11.6763	19	26.1599	0	305.45
	Low confidence	1.22585	171	181.734		222.779
		1.29112	19	3915.4	1	3032.56
26s protease regulatory subunit 4 (p26s4). [swissprot;acc:q03527]	High confidence	1.07379	1521	6376.76		5938.56
	Low confidence	1.03263	1881	8422.67		8156.56
26s protease regulatory subunit 6a (tat-binding protein 1) (tbp-1) (proteasome subunit p50). [swissprot;acc:p17980]	High confidence	1.07349	1527	6362.33		5926.76
	Low confidence	1.03218	2003	8372.5		8111.49
26s protease regulatory subunit 6b (mip224) (mb67 interacting protein) (tat-binding protein-7) (tbp-7). [swissprot;acc:p43686]	High confidence	1.07226	1567	6242.94		5822.25
	Low confidence	1.03623	1203	8556.58		8257.44
26s protease regulatory subunit 7 (mss1 protein). [swissprot;acc:p35998]	High confidence	1.07322	1539	6207.5		5783.97
	Low confidence	1.03794	1024	8703.92		8385.76
26s protease regulatory subunit 8 (proteasome subunit p45) (thyroid hormone receptor interacting protein 1) (trip1) (msug1 protein) (tat-binding protein homolog 10) (tbp10) (p45/sug). [swissprot;acc:p47210]	High confidence	1.00914	2651	9234.09		9150.44
	Low confidence	1.02789	3044	8314.51		8088.94
26s protease regulatory subunit s10b (proteasome subunit p42) (p44) (conserved atpase domain protein 44) (cadp44). [swissprot;acc:q92524]	High confidence	1.07181	1577	6349.04		5923.66
	Low confidence	1.02947	2711	8326.51		8088.12
26s proteasome non-atpase regulatory subunit 1 (26s proteasome regulatory subunit s1) (26s proteasome subunit p112). [swissprot;acc:q99460]	High confidence	1.06342	1883	6195.48		5826
	Low confidence	1.03046	2447	8063.51		7825.14
26s proteasome non-atpase regulatory subunit 10 (26s proteasome regulatory subunit p28) (gankyrin). [swissprot;acc:o75832]	High confidence	1.01545	451	2642.79	0	2683.61
		1.07134	1609	6242.44	1	5826.74
	Low confidence	1.01017	771	1609.88	0	1593.68
		1.0319	2056	8397.56	1	8137.96
26s proteasome non-atpase regulatory subunit 11 (26s proteasome regulatory subunit s9) (26s proteasome regulatory subunit p44.5). [swissprot;acc:o00231]	High confidence	1.07153	1592	6271.79		5853.1
	Low confidence	1.03984	889	8727.99		8393.58
26s proteasome non-atpase regulatory subunit 12 (26s proteasome regulatory subunit p55). [swissprot;acc:o00232]	High confidence	1.00763	474	2263.85	0	2281.12
		1.07179	1579	6261.87	1	5842.44
	Low confidence	1.00797	785	2331.31	0	2349.9
		1.03739	1073	8671.34	1	8358.82
26s proteasome non-atpase regulatory subunit 13 (26s proteasome regulatory subunit s11) (26s proteasome regulatory subunit p40.5). [swissprot;acc:q9unm6]	High confidence	1.07166	1585	6278.32		5858.48
	Low confidence	1.03225	1982	8388.54		8126.5
26s proteasome non-atpase regulatory subunit 2 (26s proteasome regulatory subunit s2) (26s proteasome subunit p97) (tumor necrosis factor type 1 receptor associated protein 2) (55.11 protein). [swissprot;acc:q13200]	High confidence	1.08451	1241	6980.13		6436.19
	Low confidence	1.03153	2168	8521.25		8260.81
26s proteasome non-atpase regulatory subunit 3 (26s proteasome regulatory subunit s3) (proteasome subunit p58). [swissprot;acc:o43242]	High confidence	1.07303	1546	6244.37		5819.39
	Low confidence	1.03175	2101	8407.98		8149.27
26s proteasome non-atpase regulatory subunit 4 (26s proteasome regulatory subunit s5a) (rpn10) (multiubiquitin chain binding protein) (antisecretory factor-1) (af) (asf). [swissprot;acc:p55036]	High confidence	1.05939	1979	5800.97		5475.74
	Low confidence	1.03275	1826	8425.82		8158.59
26s proteasome non-atpase regulatory subunit 6 (26s proteasome regulatory subunit s10) (p42a) (proteasome regulatory particle subunit p44s10). [swissprot;acc:q15008]	High confidence	1.07535	1472	6435.42		5984.47
	Low confidence	1.037	1122	8441.1		8139.9
26s proteasome non-atpase regulatory subunit 7 (26s proteasome regulatory subunit s12) (proteasome subunit p40) (mov34 protein homolog). [swissprot;acc:p51665]	High confidence	1.07208	1571	6273.4		5851.64
	Low confidence	1.02973	2648	8358.6		8117.3
26s proteasome non-atpase regulatory subunit 8 (26s proteasome regulatory subunit s14) (p31). [swissprot;acc:p48556]	High confidence	1.07344	1536	6350.53		5916.05
	Low confidence	1.03928	917	8445.39		8126.23
26s proteasome non-atpase regulatory subunit 9 (26s proteasome regulatory subunit p27). [swissprot;acc:o00233]	High confidence	1.07393	1517	6439.46		5996.14
	Low confidence	1.03429	1454	8435.4		8155.72
26s proteasome-associated pad1 homolog. [refseq;acc:nm_005805]	High confidence	1.06977	1643	6186.39		5782.92
	Low confidence	1.03218	2004	8367.09		8106.21
27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [swissprot;acc:o14653]	High confidence	1.00351	2720	5583.64		5603.24
	Low confidence	1.10006	103	5567.34		5060.92
28s ribosomal protein s12, mitochondrial precursor (mpr-s12) (mt- rps12). [swissprot;acc:o15235]	High confidence	1.05302	2153	3381.34		3560.63
	Low confidence	1.01755	4567	7505.02		7375.6

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.