MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	Value Type	Network Comparison Type	Rank	green	Interaction Map	description	red	Filtered	network_comparison

Results: HTML CSV LaTeX

Showing element 401 to 450 of 12912 in total

Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	green	description	red	network_comparison
401	4479.76	adenylate cyclase, type v (ec 4.6.1.1) (atp pyrophosphate-lyase) (adenylyl cyclase) (fragment). [swissprot;acc:o95622]	5201.41	1.16109
402		leucine-rich repeat-containing protein 15 precursor (hlib). [swissprot;acc:q8tf66]
403		fem-1 homolog b; fem-1-like death receptor binding protein; fem-1 (c.elegans) homolog b. [refseq;acc:nm_015322]
404		leucine-rich repeat protein lrrc3 precursor. [swissprot;acc:q9by71]
405		laminin gamma-1 chain precursor (laminin b2 chain). [swissprot;acc:p11047]
406		thymic stromal co-transporter. [refseq;acc:nm_033051]
407	7664.65	wiskott-aldrich syndrome protein interacting protein (wasp interacting protein) (prpl-2 protein). [swissprot;acc:o43516]	6603.41	1.16071
408	7081.46	dok-like protein. [refseq;acc:nm_024872]	6102.59	1.1604
409		docking protein 2 (p56(dok-2)) (downstream of tyrosine kinase 2). [swissprot;acc:o60496]
410		docking protein 1 (p62(dok)) (downstream of tyrosine kinase 1) (pp62). [swissprot;acc:q99704]
411		tyrosine-protein kinase frk (ec 2.7.1.112) (nuclear tyrosine protein kinase rak). [swissprot;acc:p42685]
412	4169.95	mki67 (fha domain) interacting nucleolar phosphoprotein; nucleolar phosphoprotein nopp34; nucleolar protein interacting with the fha domain of pki-67. [refseq;acc:nm_032390]	3594.31	1.16015
413	7707.8	vav proto-oncogene. [swissprot;acc:p15498]	6644.99	1.15994
414	5815.13	autophagy protein 5-like (apg5-like) (apoptosis-specific protein). [swissprot;acc:q9h1y0]	6744.05	1.15974
415	7706.18	vav-3 protein. [swissprot;acc:q9ukw4]	6647.43	1.15927
416	5223.95	n-terminal acetyltransferase complex ard1 subunit homolog (ec 2.3.1.-). [swissprot;acc:p41227]	4509.54	1.15842
417	5233.14	bag-family molecular chaperone regulator-3 (bcl-2 binding athanogene- 3) (bag-3) (bcl-2-binding protein bis) (docking protein cair-1). [swissprot;acc:o95817]	4522.71	1.15708
418	6350.19	breast carcinoma amplified sequence 2; spliceosome associated protein, amplified in breast cancer. [refseq;acc:nm_005872]	5493.1	1.15603
419		cdc5-like; cdc5 (cell division cycle 5, s. pombe, homolog)-like; cell division cycle 5, s. pombe, homolog-like; cdc5-related protein. [refseq;acc:nm_001253]
420	11830.8	hypoxanthine-guanine phosphoribosyltransferase (ec 2.4.2.8) (hgprt) (hgprtase). [swissprot;acc:p00492]	10235.2	1.15589
421	7697.78	vav-2 protein. [swissprot;acc:p52735]	6660.02	1.15582
422	6010.04	nuclear rna export factor 5 (tap-like protein 1) (tapl-1). [swissprot;acc:q9h1b4]	5206.9	1.15425
423	6010.1	nuclear rna export factor 3 (tap-like protein 3) (tapl-3). [swissprot;acc:q9h4d5]	5207.03	1.15423
424	6010.45	nuclear rna export factor 1 (tip associating protein) (tip-associated protein) (mrna export factor tap). [swissprot;acc:q9ubu9]	5207.78	1.15413
425	4301.58	saccharomyces cerevisiae nip7p homolog. [refseq;acc:nm_016101]	3729.02	1.15354
426	6853.15	pef protein with a long n-terminal hydrophobic domain (peflin). [refseq;acc:nm_012392]	5942.49	1.15325
427	13531.9	trna (5-methylaminomethyl-2-thiouridylate)-methyltransferase (ec 2.1.1.61). [swissprot;acc:o75648]	11736.6	1.15297
428	4288.17	nucleolar gtp-binding protein 1 (chronic renal failure gene protein) (gtp-binding protein ngb). [swissprot;acc:q9bze4]	3721.19	1.15237
429	7226.06	vinexin (sh3-containing adaptor molecule-1) (scam-1). [swissprot;acc:o60504]	6272.91	1.15195
430	4379.37	transcription factor dp-2 (e2f dimerization partner 2). [swissprot;acc:q14188]	3804.09	1.15123
431	4431.36	dead (asp-glu-ala-asp) box polypeptide 31 isoform 1; dead/dexh helicase ddx31. [refseq;acc:nm_022779]	3849.94	1.15102
432	6036.27	mitochondrial processing peptidase beta subunit, mitochondrial precursor (ec 3.4.24.64) (beta-mpp) (p-52). [swissprot;acc:o75439]	5244.71	1.15093
433	6036.38	mitochondrial processing peptidase alpha subunit, mitochondrial precursor (ec 3.4.24.64) (alpha-mpp) (p-55) (ha1523). [swissprot;acc:q10713]	5244.88	1.15091
434	6037.37	ubiquinol-cytochrome c reductase complex core protein i, mitochondrial precursor (ec 1.10.2.2). [swissprot;acc:p31930]	5246.38	1.15077
435	6022.6	proline synthetase co-transcribed bacterial homolog protein. [swissprot;acc:o94903]	5233.86	1.1507
436	7168.2	arg/abl-interacting protein 2 isoform 2; arg binding protein 2. [refseq;acc:nm_021069]	6230.94	1.15042
437	4348.48	suppressor of swi4 1 homolog (ssf-1) (peter pan homolog). [swissprot;acc:q9nq55]	3779.92
438	7192.88	swi/snf-related, matrix-associated, actin-dependent regulator of chromatin subfamily f member 1 (swi-snf complex protein p270) (b120). [swissprot;acc:o14497]	6252.58	1.15039
439		programmed cell death protein 6 (probable calcium-binding protein alg- 2). [swissprot;acc:o75340]
440	7192.08	calcium-dependent protease, small subunit (calpain regulatory subunit) (calcium-activated neutral proteinase) (canp). [swissprot;acc:p04632]	6251.91	1.15038
441	7192.13	grancalcin. [swissprot;acc:p28676]	6251.96
442	7192.17	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]	6251.99
443	7192.51	brg1-binding protein eld/osa1; eld (eyelid)/osa protein. [refseq;acc:nm_020732]	6252.27
444	4322.87	probable rrna processing protein ebp2 (ebna1 binding protein 2) (nucleolar protein p40). [swissprot;acc:q99848]	3758.67	1.15011
445	4315.95	ad24 protein. [refseq;acc:nm_022451]	3753.71	1.14978
446	4329.37	nucleostemin; putative nucleotide binding protein, estradiol-induced. [refseq;acc:nm_014366]	3766.03	1.14958
447	4310.89	pescadillo homolog 1. [swissprot;acc:o00541]	3751.14	1.14922
448	7190.91	ponsin; sh3-domain protein 5 (ponsin). [refseq;acc:nm_015385]	6259.3	1.14884
449	4319.69	wd-repeat protein 12 (ytm1 homolog). [swissprot;acc:q9gzl7]	3761.59	1.14837
450	5610.52	l-myc-1 proto-oncogene protein. [swissprot;acc:p12524]	4889.21	1.14753

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.